Kornam tabs 5mg #30

Kornam instruction for use

You can buy Kornam here

Composition

1 tablet contains terazosin (in the form of hydrochloride dihydrate) 2 or 5 mg.
Packaging
20, 30 pcs.

pharmachologic effect

Kornam is a peripheral postsynaptic a1 -adrenoreceptor blocker.
By blocking the a1-adrenoreceptors of the smooth muscles of the prostate gland and the bladder neck, Kornam helps to normalize urination in patients with benign prostatic hyperplasia.
It causes the expansion of arterioles and venules, reduces round focal disease and venous return to the heart, resulting in a decrease in blood pressure. Onset of hypotensive action 15 minutes after ingestion (single dose). The duration of the hypotensive effect is 24 hours. The maximum effect when taking a single dose is achieved within 2-3 hours. The maximum hypotensive effect is achieved after 6-8 weeks of therapy. With prolonged use, a decrease in blood pressure is not accompanied, as a rule, by the development of reflex tachycardia.
The drug contributes to the normalization of lipid metabolism: reduces the content of cholesterol, TG, LDL and VLDL in the blood, while increasing the number of HDL.
With the systematic use of Kornam, there is regression of left ventricular hypertrophy.

Kornam, indications for use

- Benign prostatic hyperplasia (symptomatic treatment).
- Arterial hypertension.

Contraindications

- Childhood.
- Hypersensitivity to Kornam.
With caution should be prescribed the drug for angina, coronary artery disease, hepatic or renal failure, impaired cerebral circulation, diabetes mellitus type 1.

Dosage and administration

With benign prostatic hyperplasia, the initial dose is 1 mg 1 time / day. before bedtime. Gradually, the dose is increased to 2-10 mg / day. to achieve the optimal effect. The therapeutic effect is usually marked 2 weeks after the start of treatment. To achieve a lasting effect, the course of treatment should be 4-6 weeks.
In hypertension, Kornam is prescribed in an initial dose of 1 mg / day. before bedtime. Gradually increase the dose to achieve a clinical effect. Maintenance dose is 1-10 mg 1 time / day. The maximum daily dose is 20 mg. In the case of a temporary cessation of the drug, treatment is resumed according to the same scheme.

Use during pregnancy and lactation

Kornam can be used during pregnancy and during breastfeeding in the event that the potential benefit to the mother outweighs the possible risk to the fetus or infant.

Side effects of Kornam

- In the treatment of benign prostatic hyperplasia
Since the cardiovascular system: rarely - orthostatic hypotension.
From the side of the central nervous system: drowsiness, dizziness, asthenia.
Other: nasal congestion.
- In the treatment of hypertension
On the part of the cardiovascular system: orthostatic hypotension - the “first dose effect” (observed in 1% of patients, mostly receiving diuretics or beta-blockers at the same time), manifested by dizziness, tachycardia, fainting; rarely - palpitations, peripheral edema, nasal congestion.
From the side of the central nervous system: rarely - dizziness, asthenia, drowsiness, impaired clarity of visual perception.
On the part of the hematopoietic system: a decrease (associated with hemodilution) of hematocrit, hemoglobin, leukopenia, hypoproteinemia, hypoalbuminemia.
Other: rarely - reduced potency, nausea.

special instructions for Kornam

To prevent the development of orthostatic hypotension, treatment should begin with the appointment of Kornam at a dose of 1 mg / day. before bedtime, after which the patient should be in bed for 6-8 hours.
The risk of orthostatic arterial hypotension ("first dose effect") is highest within 30-90 minutes after taking Kornam and increased in patients simultaneously receiving beta-blockers and diuretics, with a decrease in BCC, a hypo-salt diet, and also with the resumption of drug treatment after the break (several days).
In the case of a temporary cessation of treatment, resume therapy with the same dose. During treatment, the level of prostate specific antigen does not change. Before starting therapy for benign prostatic hyperplasia, it is necessary to exclude prostate cancer.
The patient must be informed about the increased risk of orthostatic hypotension in the use of alcohol, prolonged standing or exercise, as well as in hot weather.
Within 12 hours after taking the first dose, after increasing the dose or interrupting therapy, it is not recommended to engage in potentially hazardous activities that require increased attention and quickness of psychomotor reactions.

Interaction

With simultaneous use of Kornam and beta-blockers, diuretics, calcium channel blockers, ACE inhibitors, the antihypertensive effect may be enhanced. Special care is required with the simultaneous appointment of terazosin and antihypertensive drugs of central action.
Terazosin absorption is reduced while taking adsorbents and antacids.
Adrenomimetics weaken the effect of terazosin.
With simultaneous use of terazosin and NSAIDs, it is possible to reduce the antihypertensive effect due to the suppression of the synthesis of prostaglandins and the retention of fluid and sodium ions.

Overdose

Symptoms: pronounced decrease in blood pressure, impaired coordination of movements, fainting.
Treatment: it is necessary to put the patient down by lowering the head end of the bed. If necessary, appoint hypertensive agents, in / in the introduction of fluid. Hemodialysis is not effective.
Shelf life - 3 years.

Storage conditions

At a temperature not higher than 25 ° С.

Terms of sell

You canbuy Kornam without a prescription.