Terazosin tabs 5mg #20

Terazosin instruction for use

Reed more and buy Terazosin on this page

Composition

One tablet can contain 2 mg, 5 mg Terazosin hydrochloride.

Form of issue

Tablets Terazosin packed in the cell outline packaging of 10 tables, in one pack - 20 tablets.
Israeli tablets produced by Terazosin Teva are distinguished by a flat-cylindrical facet and engravings from different sides - "93" and "762", they have a yellowish-brown color, inclusions are possible.

pharmachologic effect

Antidisuric, vasodilating, hypolipidemic.

Pharmacodynamics and pharmacokinetics

Terazosin is an α1-adrenoblocker that is able to selectively block α1-adrenergic receptors in the smooth muscles of celiac vessels, prostatic vessels, and the neck of the bladder. As an antihypertensive drug expands large resistance vessels and reduces OPSS, activates the system of RAS (renin-angiotensin-aldosterone).
Relaxation of the smooth muscles of the neck of the bladder and contractile elements of the prostate, help reduce the dysuric phenomenon, for example, with adenoma. Due to a decrease in the level of total cholesterol, triglycerides, an increase in the level of HDL is normalized lipid profile in plasma. Long-term therapy leads to regression of left ventricular hypertrophy.

The pharmacokinetics of Terazosin

After ingestion, Terazosin undergoes rapid, almost complete absorption (bioavailability above 90%). Pre-system biotransformation is insignificant, therefore, to achieve maximum plasma concentration, only 1 hour is needed. In plasma, 90-94% of the substance binds to proteins. Metabolism in the liver occurs before the formation of 4 metabolites.
Half-life is no more than 12 hours, about 40% is excreted by the kidneys (up to 10% is unchanged Terazosin), the remaining 60% is through the intestine (more than 50% are biodegradation products). If a patient has liver pathology, then a decrease in clearance and prolongation of pharmacological effects are possible.

Indications for use

    symptomatic treatment of prostate adenoma (benign prostatic hyperplasia of the prostate gland);
    monotherapy or complex treatment of hypertension.

Contraindications

Patients with known hypersensitivity, arterial hypotension, pregnant, breast-feeding mothers. The drug is not used in pediatrics.
Restriction to use is also ischemic heart disease and other heart diseases, failure of renal or hepatic function, impaired blood circulation in the brain, hypertensive retinopathy of III-IV degree, diabetes mellitus of the first type.

Side effects

The use of Terazosin may cause the following adverse reactions:
    weakness and rapid fatigue;
    Drowsiness, anxiety, headaches, dizziness;
    paresthesia (sensations of numbness, tingling);
    decreased libido;
    impaired vision, hearing (noise);
    hypotension, tachycardia, arrhythmia;
    peripheral edema;
    bronchitis, cough;
    xerostomia, pharyngitis, dyspeptic disorders;
    arthralgia, myalgia;
    reduction of hemoglobin, as well as hematocrit, development of leukopenia, hypoalbuminemia, hypoproteinemia;
    allergic reactions are possible;
    influenza-like syndrome.
Attention! Perhaps the emergence of a "first-dose phenomenon", usually accompanied by a decrease in blood pressure, even orthostatic collapse is possible. Such an organism reaction may occur after the first dose, especially in combination with diuretics or β-blockers.

Terazosin, instructions for use (Method and dosage)

Tablets should be taken orally inwards. The initial daily dose is 1 mg, later it can be gradually increased to 10-20 mg. Take for 1 reception - preferably at bedtime.

Overdose

Symptomatology
Tachycardia, hypotension, orthostatic collapse is possible.

First aid and treatment

Move the patient to the horizontal position so that the head end of the bed is lowered. In addition, intravenous fluid and hypertensive medications are recommended.
It is known that hemodialysis is ineffective, but there is no specific antidote.

Interaction

    with diuretics, adrenoblockers, calcium antagonists, myotropic drugs and drugs that suppress the hormonal system (RAS) - their hypotensive activity increases;
    With antacids and adsorbents, absorption decreases;
    with adrenomimetics, the effectiveness of therapy is weakened.

Terms of sale

To buy Terazosin you don't need a prescription.

Storage conditions

The preparation of list B: a dry, protected from light place, the temperature is up to + 25 ° Celsius.
Shelf life - 36 months.

special instructions

At an adenoma of a prostate before application of a preparation it is necessary to exclude malignancy of a neoplasm. At the beginning of therapy and when changing the dose, control is necessary. The effectiveness of treatment is advisable to evaluate after 4-6 weeks.

Reviews about Terazosin

Terazosin is a well-known tested drug, which patients respond positively. However, it is necessary to use domestic analogues - Kornam, Setegis or to look for foreign preparations of German production - Terazosin Sandoz or Israeli - Terazosin-Teva.
The drug effectively helps to fight with increased blood pressure, and is also used for benign prostatic adenoma.