Tamsulosin 0.4mg #30

Instruction manual for Tamsulosin

You can buy Tamsulosin online

Composition

The drug contains tamsulosin hydrochloride.

Form of issue

Tamsulosin is produced in the form of semi-finished pellets in bags, as well as substances in granules and powder.
In addition, such forms of release as Tamsulosin hydrochloride (substance-powder, semi-finished pellets) and Tamsulosin-Teva (capsules and tablets) are popular.

pharmachologic effect

Selective inhibitor of alpha-adrenoreceptors, is used in the treatment of benign prostatic hyperplasia.

Pharmacodynamics and pharmacokinetics

The active substance of the preparation is a white powder, poorly soluble in water and methanol. It also dissolves little in ethanol and glacial acetic acid and almost does not dissolve in ether.
Tamsulosin reduces the tone of smooth muscle organs and contributes to the outflow of urine. Selectively and competitively inhibits postsynaptic alpha-1 adrenoreceptors located in the neck of the bladder, smooth muscles of the prostate, the prostatic part of the urethra. Tropism to alpha1a-adrenergic receptors, which are located in the bladder, many times exceeds the interaction with alpha-1b-adrenoreceptors located in the smooth muscle of the vessels.
Therapeutic effect after the start of the course is observed after a couple of weeks. The degree of absorption is more than 90%. The maximum concentration after one intake is observed after 6 hours. The association of the preparation with plasma proteins is approximately 97%.
The active substance is slowly cleaved in the liver, resulting in active metabolites. The main part is in the blood in an unchanged form. Excreted unchanged by the kidneys by about 7%.

Indications for use

This drug is used for benign prostatic hyperplasia.

Contraindications

You can not use the drug in severe renal failure, severe hepatic insufficiency, hypersensitivity to the active substance, orthostatic hypotension (including when there is an anamnesis).

Side effects

When using the medicine, the following undesirable side effects are likely:
    CNS: headache, dizziness, asthenia, sleep disturbance, drowsiness;
    gastrointestinal tract: nausea, constipation, vomiting, diarrhea;
    allergies: rashes, hives, itching, swelling of Quincke;
    SSS: orthostatic hypotension, palpitations, pain in the chest, fainting, tachycardia;
    genitourinary system: priapism, retrograde ejaculation, decreased libido.
In addition, back pain and rhinitis are possible.

Instructions for use of Tamsulosin (Method and dosage)

The product is intended for internal use. Instructions for use Tamsulosin reports that a single dose is 400 μg. The medicine is taken once a day in the morning after a meal.

Overdose

In case of an overdose of the drug, headache or orthostatic hypotension is possible. The patient should be immediately put in bed and call a doctor.

Interaction

Probably an increase in antihypertensive effect and the appearance of orthostatic hypotension when combined with Amlodipine and Perindopril. This combination requires caution.
Antihypertensive action is possible when interacting with ramipril and amlodipine. The combination of these drugs should be administered with caution.
The rate of removal of the active substance of the drug is increased by interaction with Warfarin and Diclofenac.
The hypotensive effect increases with Doxazosin, Terazosin, and Prazosin. This combination is not recommended.
The maximum concentration of the active substance of the drug increases with the use of ketoconazole and paroxetine, and also decreases when combined with Furosemide.
Interaction with cimetidine leads to a decrease in clearance and an increase in the AUC of the active component of the described preparation.

Storage conditions

Optimum storage temperature up to 25 ° C. Keep out of the reach of small children.

Shelf life

The medicine is stored no longer than 36 months.

Reviews about Tamsulosin

Reviews about Tamsulosin, as a rule, are positive. This drug is characterized as an effective and relatively safe remedy. On adverse reactions reported rarely.