Urorec caps 8mg #30

Urorec instruction for use

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Composition

The preparation contains the active ingredient silodosin, as well as mannitol, pregelatinized starch, magnesium stearate, sodium lauryl sulfate as auxiliary substances.
The gelatin capsule consists of gelatin, iron oxide of yellow oxide, titanium dioxide.

Form of issue

The Urorec is available in hard gelatin capsules that have a yellow color. Inside the capsules there is a fine crystalline or amorphous powder, it can be white or light yellow.
Capsules are packed in blisters for 5 or 10 pieces, in the package can be from 1 to 20 blisters. Capsules containing 4 or 8 mg of active substance are available.

pharmachologic effect

The Urorec agent is used by male patients suffering from urinary disorders due to the development of benign prostatic hyperplasia.
Under the influence of the active substance, which is part of the drug, the severity of irritation and obstruction, which are manifested in patients with benign prostatic hyperplasia, decreases. The effect of the drug is associated with a decrease in the tone of the smooth muscles of the prostate, as well as the tone of the prostatic part of the urethra and the neck of the ureter. As a consequence, the outflow of urine improves.
The urorec does not affect human blood pressure due to the high selectivity of the active component.
The substance of silodosin is a competitive highly selective α1A-adrenoreceptor antagonist.

Pharmacokinetics and pharmacodynamics

After oral administration, the substance silodosin is well absorbed. The level of its bioavailability is 32%. The maximum concentration reduces food intake by 30%, while the period of reaching the highest concentration increases. Silodosin binds to plasma proteins by 96.6%.
Metabolized by glucuronation. The main metabolite, carbamoyl-glucuronide in plasma, reaches a concentration 4 times higher than silodosin itself. About a third of the silodosin is excreted from the body with urine, about 55% through the intestine.
The half-life of silodosin and carbamoyl-glucuronide is 11 and 18 hours, respectively. There is no significant dependence of pharmacokinetics on the patient's age.

Indications for use

Urorec is indicated for use in the treatment of benign prostatic hyperplasia.

Contraindications

Do not use the drug Urorec in the following cases:
    age to 18 years;
    hepatic and renal failure in severe degree;
    high sensitivity to any component of the drug;
    pregnancy, as well as breastfeeding;
    cautiously the agent is appointed or nominated at an average degree of renal failure.

Side effects of Urorec

Most often when using the drug Urorec such side effects are manifested:
    retrograde ejaculation, anejaculation, erectile dysfunction, decreased libido;
    orthostatic hypotension;
    dizziness;
    sensation of nasal congestion;
    nausea, diarrhea, dry mouth.
If during the reception of the remedy there is a decrease in blood pressure, or dizziness or weakness manifests, you should sit or lie down.
When conducting operations for cataracts, the drug can provoke the development of intraoperative syndrome of the "flabby" iris. Therefore, stop taking this medication you need 1-2 weeks before the proposed surgery.

Instructions for Urorec (Method and dosage)

Instruction for the use of Urorec suggests that the dose of the drug per day is 8 mg. Capsule should be taken once a day, at the same time of day.
In a reduced dose (4 mg), the drug is administered during the first week of therapy to people who are diagnosed with moderate to moderate renal failure. If the drug is well tolerated, the dose is increased to 8 mg.

Overdose

If an overdose occurs, the patient may have decreased blood pressure, compensatory tachycardia may appear. Treatment in this case involves washing the stomach, taking a laxative or activated carbon.
Symptomatic treatment is also performed, and the use of vasoconstrictive drugs is practiced. Dialysis in this case is ineffective.

Interaction

Urorec should not be combined with other alpha-adrenoblockers, since it is possible to show potentiation of the action.
With the simultaneous use of inhibitors of the isoenzyme CYP3A4 in plasma, the concentration of silodosin increases. Therefore, such a combination should not be practiced.
Tadalafil, sildenafil - inhibitors of PDE5- with simultaneous application with the drug Urorec can provoke the appearance of dizziness.
Hypotensive drugs (calcium antagonists, beta-adrenoblockers, diuretics, agents that affect RAAS) increase orthostatic hypotension with simultaneous application.

Terms of sale

You can buy Urorec without a prescription.

Storage conditions

The yarrow should be stored at a temperature of no higher than 30 ° C.
Shelf life - 2 years.

special instructions

In the process of taking drugs with silodosin, blood pressure may decrease, orthostatic hypotension may appear.
Since benign prostatic hyperplasia can have symptoms similar to a tumor, in addition, hyperplasia and a tumor can develop simultaneously, before the appointment of this drug it is important to undergo research and exclude the presence of tumors.
In the process of therapy with Urorec, the male reduces the amount of seminal fluid. As a consequence, male fertility may decline. After the drug is stopped, this phenomenon disappears.
It is not recommended to start treatment with Urorec medicine for people who are undergoing surgery for cataracts.
There is no evidence of an effect on a person's ability to drive a vehicle. But the patient should be warned that during the treatment may occur manifestations of orthostatic hypotension.

Children

Not appointed until 18 years of age.
Silodozin is taken exclusively by men.

Reviews about Urorec

Men often leave feedback about Urorec in forums where it is about the effectiveness of the tool. It was noted that the drug reduces pain during urination, allows you to get rid of other unpleasant symptoms.
As negative comments, there are opinions that, as a result of taking the drug, the amount of seminal fluid decreases, the acuity of sensations during sexual intercourse decreases.