Dalfaz sr tabs 10mg #30

Dalfaz instruction for use

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Composition

Alfuzosin hydrochloride, polyvidone, microcrystalline cellulose, calcium hydrogenphosphate, magnesium stearate, hypromellose, titanium dioxide, hydrogenated castor oil, propylene glycol, iron oxide yellow.

Form of issue

Tablets in a coat of beige color round biconvex in a blister pack of 14 tablets in carton No. 56 (Dalfaz Retard) and No. 30 (Dalfaz SR).

pharmachologic effect

Eliminating disturbances of urination.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug is a quinazoline derivative and belongs to the group of α1-adrenoblockers. The mechanism of action is the selective effect on postsynaptic adrenoreceptors that are located in the urethra (prostatic part) and the bottom of the bladder. Alfuzozin affects the tissues of the prostate gland (smooth muscle) and thereby reduces the resistance of urine outflow from the bladder and normalizes the parameters of urination (reducing the tone of the urethra, improves the emptying of the bladder). In this case, the volume of urine released and the decrease in its residual volume increase.

Pharmacokinetics

When receiving Dalfaz SR, which provides a sustained release of the active ingredient of alfuzosin, the average bioavailability of the drug as compared with the form of the immediate release preparation increases to 104%. Binding to blood proteins is about 90%. Metabolised in the liver. T1 / 2 is 9 hours. It is excreted through the kidneys, mostly unchanged and through the intestines in the form of pharmacologically inactive metabolites.

Indications for use

    Dalfaz Retard and Dalfaz SR - symptomatic treatment of benign prostatic hyperplasia;
    Dalfaz SR - as an auxiliary drug for acute retention of urine with prostatic hyperplasia during catheterization.

Contraindications

High sensitivity to the drug, liver disease, kidney, hypotension, intestinal obstruction due to the presence of castor oil in the preparation.

Side effects

Drowsiness, dizziness, asthenia, headache, hypotension, tachycardia, attacks of angina in the presence of the patient's IHD, nausea, chest pain, dry mouth, abdominal pain, itching, rash, diarrhea, rhinitis.

Dalfaz, instructions for use (Method and dosage)

The drug Dalfaz Retard is taken in a dosage of 5 mg (l tablet) in the morning and evening. Tablets can not be chewed, swallowed whole, washed down with water.
Dalfaz SR - 10 mg (1 tablet) once a day swallowing whole after meals from the first day of catheterization.
The drug should be taken during the entire period of application of the catheter (3-4 days) and 1 day after its removal.

Overdose

Tachycardia, arterial hypotension.

Interaction

It is not recommended to take Dalfaz together:
    with drugs-blockers of α1-adrenergic receptors (minoxidil, prazosin, urapidil) because of the high risk of developing severe postural hypotension;
    with inhibitors of CYP3A4 (itraconazole, ketoconazole, ritonavir) because of the risk of increasing the concentration of alfuzosin in the blood;
    with drugs that have hypotensive effect because of the risk of increased hypotensive effect.

Terms of sale

You don't need a prescription to buy Dalfaz.

Storage conditions

At a temperature of 15-25 ° C.
Shelf life - 3 years.

Reviews of Dalfaz

Reviews about the drug in patients vary. Some of them note positive dynamics.
"... We prescribed the drug Dalfaz. After 10 days of intake, the number of nocturnal urination decreased, and began to sleep normally. There was a small erection. I did not notice any side effects. "
Other patients say that there is no visible effect: "... Drank Dalfaz for almost a month. I did not notice any improvement. "