Omnic caps 0.4mg #30

Omnic instruction for use

Reed more and buy Omnic capsules on this page

See also - Omnic Ocas

Composition

1 capsule Omnic contains 400 micrograms of tamsulosin.
In addition: microcrystalline cellulose, triacetin, methacrylic acid (C type) copolymer, sodium lauryl sulfate, polysorbate 80, calcium stearate, talc, indigodin, gelatin, titanium dioxide, iron oxide, yellow and red.

Form of issue

The remedy Omnic is made in the form of capsules with modified release №10, №30 or №100 in the package.

pharmachologic effect

Alpha-adrenolytic.

Pharmacodynamics and pharmacokinetics

Tamsulosin refers to drugs from a group of specific blockers of postsynaptic alpha 1-adrenergic receptors present in the smooth muscles of the prostate (prostate), the prostatic urethra and the neck of the male bladder. When tamsulosin is blocked by alpha1-adrenergic receptors, the muscle tone of the prostate gland, the prostatic urethra and the bladder are reduced, which leads to an improvement in urination. In parallel, there is a decrease in the symptoms of emptying and filling the bladder in prostate adenoma, which are caused by detrusor hyperactivity and high muscle tone of these organs.
The effect of tamsulosin on the adrenoreceptors of the alpha 1A subtype is 20 times greater than its effect on the adrenoreceptors of the alpha 1B subtype located in the smooth muscle tissue of the vessels. Because of this high selectivity, tamsulosin does not result in clinically significant lowering of systemic BP, both in patients with normal blood pressure and in patients with arterial hypertension, from which Omnic may be prescribed to hypertensive patients.
In the intestine, tamsulosin is absorbed fairly well and has almost 100% bioavailability. With a combined intake of food, the suction process slows down a little. Equivalent degree of absorption of the drug can be achieved with a constant admission tamsulosin patient after a daily breakfast.
Typical for tamsulosin is its linear kinetics. A single internal intake of 0.4 mg of the drug results in its plasma Cmax after 6 hours. With a constant daily oral intake of 0.4 mg of tamsulosin, its equilibrium concentration is already observed by the 5th day, while at the same time about 2/3 higher than the value observed with a single dose of the drug. Binding to plasma proteins occurs at 99%, Vd approximately 0.2 l / kg.
Hepatic metabolic transformations of tamsulosin are rather slow, with the release of less active metabolic products. The bulk of tamsulosin is in the blood plasma in a natural unmodified form.
The conducted studies of tamsulosin have shown its ability to insignificantly induce the activity of microsomal hepatic enzymes.
With liver pathologies, up to a moderate degree, Omnic's dosage regimen is not required.
Unchanged tamsulosin, like the products of its metabolism, is mainly excreted by the kidneys. T1 / 2 once taken orally dose (0.4 mg) of the drug after meals is equal to 10 hours. With multiple admission, this indicator is 13 hours.
If kidney pathology is of a moderate nature, no adjustment of doses of tamsulosin is required. In the case of severe kidney failure (CC less than 10 ml / min), there is a need for the careful appointment of Omnic.

Indications for use

Indications for use Omnic drug include therapy for dysuric disorders observed with prostate adenoma.

Contraindications

    personal hypersensitivity of the patient to tamsulosin or other capsule ingredients;
    severe failure of the hepatic function;
    orthostatic hypotension (including indications in history).
A careful application of the Omnic is required by patients with severe kidney pathologies (CC less than 10 ml / min).

Side effects

When carrying out therapy with capsules, Omnic occasionally observed:
    retrograde ejaculation;
    dizziness;
    formation of orthostatic hypotension;
    nausea / vomiting;
    asthenia;
    constipation;
    tachycardia / palpitations;
    headache;
    diarrhea;
    hypersensitivity phenomena (including skin rash / itching, Quincke's edema).

Omnic, instructions for use

Taking Omnic's capsules prescribes their oral (oral) intake immediately after completing breakfast, with 100-200 ml of water. In a day, 400 μg of preparation (1 capsule) is indicated. Instructions for use Omnica does not allow chewing capsules, as this can lead to an increase in the release rate of the active ingredient from them.

Overdose

There is no evidence of acute overdose with tamsulosin. Theoretically, when taking excessive doses of this drug, there can be a rapid decline in blood pressure and the development of compensatory tachycardia, requiring symptomatic treatment. The heart rate and blood pressure of the patient can return to normal when taking a horizontal position. In the case of ineffectiveness of this method, it is possible to use drugs that increase the volume of blood circulating in the vascular bed. If necessary, prescribe vasoconstrictive drugs. Against the background of ongoing treatment, it is necessary to monitor the renal function. The effectiveness of hemodialysis due to the significant binding of tamsulosin to plasma proteins is being questioned. It will also be expedient to purify the digestive tract (laxative, lavage) and sorbent intake.

Interaction

The concomitant use of tamsulosin with Atenolol, Nifedipine or Enalapril did not lead to any interaction of these drugs.
With concurrent use of cimetidine, a slight increase in plasma concentrations of tamsulosin was observed, and with Furosemide, a decrease in this index was observed. This combination of drugs does not require a change in the dosage regimen Omnica, since the content of its active ingredient in the plasma remains within the therapeutic norm.
Warfarin, Propranolol, Diazepam, Trichloromethiazide, Amitriptyline, Chlormadinone, Diclofenac, Simvastatin and Glibenclamide do not affect the free fraction in the plasma of tamsulosin in vitro, which in turn does not interfere with the free fractions of Chlormadinone, Propranolol, Diazepam and Trichloromethiazide.
Also in vitro at the level of metabolism in the liver, no interaction of the active ingredient Omnic with Amitriptyline, Glybenklamid, Salbutamol and Finasteride was noted.
The simultaneous administration of warfarin and diclofenac can increase the rate of excretion of tamsulosin.
When combined with other antagonists of alpha 1-adrenergic receptors, a decrease in blood pressure is possible.

Terms of sale

To buy Omnic you don't need a prescription.

Storage conditions

The temperature of the capsules should be between 15-25 ° C.
Shelf life - 4 years.

special instructions

When carrying out therapy with Omnic, occasionally a decrease in the blood pressure of the receiving patient was observed, which could cause a syncope. In the case of the first signs of the formation of orthostatic hypotension (feeling of weakness, dizziness), the patient is recommended to take a sedentary or horizontal position, up to the complete disappearance of negative symptoms.
Conducting surgical interventions on the organs of vision regarding cataracts with tamsulosin may lead to the onset of intraoperative instability of the ocular iris, which must be remembered for surgical personnel for proper preoperative preparation of the patient.
Before beginning treatment with Omnic, the patient must undergo a screening to exclude pathologies with symptoms similar to manifestations of prostate adenoma.
Prior to the appointment of therapy, and regularly throughout its duration, the patient should be given a rectal finger examination and, if necessary, determine the presence of a specific prostatic antigen.

Omnic and Omnic Ocas

These drugs are 100% synonymous, that is, they include the same active ingredient (tamsulosin) in the same mass portion (400 μg). Naturally, patients with prostate adenoma often wonder what makes Omnic different from Omnic Ocas. The difference in these drugs lies in their dosage form, capsules for the first and tablets for the second, Omnic Okas tablets being characterized by controlled release, in other words, have a more constant concentration of their active ingredient observed in the body throughout the day. This quality of tablets allows tamsulosin to exert the same effect on the musculature of the prostate for 24 hours, and, because of the absence of differences in the concentration of the active ingredient, less often leads to the development of negative side effects, which makes Omnic Okas tablets more effective and safe.

Children

Due to the formation of prostate adenoma, mainly in adulthood, Omnic's appointment to children is not practiced.

During pregnancy (and lactation)

The drug is intended exclusively for the treatment of male patients.

Reviews about Omnic

In 70% of cases, reviews of doctors, as well as patients' reviews about Omnic's effectiveness, when applied strictly according to indications, are positive. Many urologists prescribe this medicine for prostatitis, adenoma of the prostate and other painful conditions that occur with problems of urination, where the relaxing effect of tamsulosin on the musculature of the prostate really helps to get rid of the negative symptoms of the disease.
In fairness, it is worth noting some negative reviews about Omnic on forums discussing its side effects, the most significant of which are the development of hypotension and retrograde ejaculation. It is also necessary to remember that in the treatment of prostate adenoma, Omnic's appointment has a symptomatic load aimed at getting rid of dysuric disorders, and the full treatment of this disease requires an integrated approach, using the drugs of various groups shown in such pathologies.