Fokusin caps 0.4 mg #90

Fokusin user manual

To buy Fokusin just add it to your shopping cart

Composition

Fokusin includes:
    0.4 mg of tamsulosin (Tamsulosinum);
    dispersion of the methacrylate copolymer;
    microcrystalline cellulose;
    dibutyl sebacate;
    polysorbate 80;
    silicon dioxide colloidal water;
    talc.
Capsule shell composition:
    azorubin (E122);
    dye patented blue V (E131);
    gelatin.

Form of issue

The preparation is available in the form of hard, gelatin-coated capsules with modified release. Capsules have a size of 1, a transparent body with a dark blue lid and are filled with micropellets, the color of which varies from almost white to white.
In one package there may be 30 or 90 capsules.

pharmachologic effect

Fokusin belongs to the pharmacological group of drugs-alpha-adrenoblockers, as well as to a group of drugs that affect the course of metabolic processes in the prostate gland and correct urodynamics.
The therapeutic effect of the drug is determined by the activity of the tamsulosin hydrochloride included in its composition, which is a white powder with a crystalline structure, poorly soluble in water, slightly soluble in glacial acetic acid and ethyl alcohol and practically insoluble in ethers.

Pharmacodynamics and pharmacokinetics

Like other alpha-blockers, Fokusin has the ability to screen alpha receptors located on postsynaptic membranes and react to the action of the neurotransmitter norepinephrine, which is released from the nerve endings of sympathetic postganglionic neurons, that is, the efferent neurons of the autonomic nervous system that form the synapse with target organs.
Tamsulosin, which is a typical representative of the group of selective alpha 1-adrenoblockers, contained in it as an active ingredient, prevents the passage of vasoconstrictor impulses through adrenergic synapses, thereby provoking the expansion of arterioles and precapillaries.
Another effect that is due to the ability of tamsulosin to competitively block the alpha1A-adrenergic receptors located in the triangle zone is the "prostatic part of the urethra - the lower narrowed part of the bladder (its neck) - the smooth muscles of the prostate gland", as well as the alpha 1D-adrenergic receptors, which are localized predominantly in the muscular membrane of the bladder (detrusor), is an improvement in urodynamics in prostatic adenoma.
The clinical effect of taking Fokusin is noted approximately two weeks after the start of the course of treatment. Against the background of taking the drug in patients to a large extent:
    enlarges the lumen of the urethra;
    enlarges the lumen of the neck of the bladder;
    blood supply to the detrusor is normalized;
    improves metabolism in the musculature of the bladder;
    decreased pressure in the urethra;
    symptoms of obstruction of the urinary tract are removed;
    decreases the severity of symptoms of irritation due to prostatic adenoma;
    decreases resistance to the current of urine;
    normalization of urination.
The ability of Focus to affect alpha 1A-adrenergic receptors is several times higher than its ability to interact with alpha 1B-adrenergic receptors that are in the smooth muscle of the vessels.
Due to this high selectivity, the drug does not provoke a clinically significant decrease in blood pressure values. And a similar effect is observed both in patients with normal arterial pressure, and in patients who have arterial hypertension diagnosed.
The process of absorption of tamsulosin is carried out in the gastrointestinal tract. The greatest activity of absorption is noted in the case when the drug is taken immediately after ingestion.
The indicator of bioavailability of tamsulosin is almost 100%, and its kinetics is linear.
After a single dose of the recommended single dose of the drug, if the patient is fed, the maximum plasma concentration of tamsulosin is observed for approximately six hours.
Steady state is achieved after five days of continuous reception of Fokusin. At the same time, the maximum plasma concentration of tamsulosin on average is ⅔ higher than the same figure after receiving the single dose recommended by the instruction.
This increase was noted in elderly patients, however, a similar effect is expected in people of a younger age.
After oral administration, approximately 99% of tamsulosin entering the body binds to plasma proteins, and its distribution volume is about 0.2 l / kg and is characterized as low.
Metabolization of the substance proceeds slowly enough, and the effect of the "first passage", that is, the metabolism before entering the systemic circulation when passing through the wall of the gastrointestinal tract and the liver, is insignificant.
The bulk of tamsulosin is found in the blood plasma unchanged, finally the substance is biotransformed in the liver.
Formed metabolites and tamsulosin in an unchanged form (approximately 9% of the dose received in the body) are especially actively excreted in the urine.
The half-life of the substance after a single dose, if the patient is fed, is about 10 hours. With stable indices of plasma concentration of tamsulosin, its half-life is increased to 13 hours.
Indications for use
Fokusin tablets are prescribed for the treatment of dysuric disorders caused by benign prostatic hyperplasia (adenoma).

Contraindications

The drug is not assigned to the following categories of patients:
    people who have an increased sensitivity to tamsulosin or other substances that make up Fokusin;
    people who have signs of orthostatic hypotension (including in the anamnesis).
It is not recommended that Focus should be administered to patients with severe hepatic and / or renal forms (when the creatinine clearance is below 10 ml / min), insufficiency. This is due to the lack of data on the safety of the drug on patients with similar pathologies.

Side effects of Focusis

Like most other drugs, Foccusin in some cases can cause unwanted adverse reactions of varying severity, which include:
    disorders of the nervous system, expressed as dizziness (often), headaches (infrequently), loss of consciousness (extremely rare);
    violations of the heart and vascular system (occur infrequently and expressed as symptoms of postural (orthostatic) hypotension and enhanced, well palpable palpitation);
    violations of the respiratory system, organs located in the chest and anatomical space in the middle of the thoracic cavity (the most common manifestation of this group of side effects is rhinitis);
    gastrointestinal disorders, which are expressed in the form of disorders of the stool, attacks of nausea and vomiting (these symptoms occur infrequently);
    disorders of the sexual system, which can sometimes be expressed in the form of retrograde ejaculation (i.e. ejaculation characterized by ejection of sperm in the opposite direction) and very rarely in the form of a long painful erection not associated with sexual arousal (priapism).
Other side effects, which are noted against the background of taking Fokusin, are infrequent asthenia, and also the narrowed pupil syndrome (unstable iris). The latter can develop during the surgical treatment of cataracts in patients who have been taking tamsulosin for a long time.

Fokusin: instructions for use, method and dosage

According to the instructions for the use of Fokusin tablets, the optimal dose for adult patients is 1 capsule per day.
The drug is recommended to be taken after breakfast or after the first meal, while standing or sitting. The tablet is swallowed whole, without chewing (otherwise the mechanism of modified release of tamsulosin will be violated), and washed down with a large amount of liquid - water or milk (at least 150 ml).

Overdose

In the event that the admissible therapeutic dose of Fokusin is exceeded, the risk of developing symptoms of acute arterial hypotension is high.
If this happens, in order to prevent further absorption of tamsulosin, the patient is made to wash the stomach with activated charcoal or similar preparations, laxatives with osmotic properties (eg Glauber's salt).
During the care of the patient, the patient should be in a horizontal position. If necessary, he may be prescribed vasoconstrictive drugs.
In parallel with symptomatic treatment, measures are taken to provide general support to the patient's organism and constantly monitor the indicators of the functional state of his kidneys.
With an overdose of Fokusin, dialysis does not belong to the category of expedient procedures, since tamsulosin binds to plasma proteins.

Interaction

With the simultaneous reception of Fokusin with beta-adrenoblocker Atenolol, as well as antihypertensive drugs Enalapril and Nifedipine, there was no interaction of drugs.
Combined use with antiulcer drug Cimetidine provokes an increase in plasma concentrations of tamsulosin. The opposite effect is noted with the simultaneous administration of the drug with a diuretic Furosemide, but this does not require adjustment of the dose of Fokusin.
Studies conducted in vitro on microsomal liver fractions belonging to the cytochrome P450 enzyme system have shown that tamsulosin has the ability to interact with:
    tricyclic antidepressant Amitriptyline;
    bronchodilator drug Salbutamol;
    hypoglycemic drug Glibenclamide;
    antitumor hormonal drug Finasteride.
Simultaneous appointment of Fokusin with Diclofenac and Warfarin provokes an increase in the rate of excretion of tamsulosin from the body.
Anxiolytic Diazepam, beta adrenoblocker Propranolol, thiazide diuretic Trichloromethiazide and hypocholesterolemic drug Simvastatin do not affect the free fraction (i.e., the part that is dissolved in the aqueous phase of the blood plasma) of tamsulosin in the blood.
The combination with antagonist preparations of alpha1A-adrenergic receptors can contribute to an increase in the severity of the hypotensive effect.

Terms of sale

To buy Fokusin the prescription is not required.

Storage conditions

Keep out of reach of children. There are no other requirements for storage conditions.
Shelf life - 2 years.

Reviews about Focusin

Many men with prostatitis or prostate adenoma are forced to take tamsulosin drugs.
Analyzing reviews of patients about Focus, we can conclude that most of them like this drug much more than Omnic - one of the most frequently assigned its analogues.
Comments on the forums indicate that when choosing Fokusin or Omnic, many prefer the first, because it provokes less often such an unpleasant phenomenon as retrograde ejaculation.
Almost all patients note a noticeable positive effect of its use: urination does not cause such problems as before the course of treatment, and imperative urges to it disappear.
For some of them, the most effective scheme is that according to which the Fokusin is administered after antibiotic treatment with prostatitis or prostate adenoma.