Omnic Ocas tabs 0.4mg #30

Omnic Ocas instruction

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Composition

1 tablet contains 400 μg of tamsulosin.
In addition: macrogol 8000 and 7000000, magnesium stearate, purified water, shell - yellow opadrai 03F22733.

Form of issue

Omnic Ocas is produced in the form of tablets in a shell with controlled release of No. 10 or No. 30 in the package.

pharmachologic effect

Alpha-adrenolytic, antidisuric.

Pharmacodynamics and pharmacokinetics

The active ingredient Omnic Ocas-tamsulosin belongs to the group of drugs that are competitive specific blockers of postsynaptic alpha 1-adrenergic receptors, which have a special affinity for their alpha1A and alpha1D subtypes, responsible for the relaxation of the smooth muscle tissue of the prostate, the prostatic urethra and the neck of the bladder. The orally taken dosage of tamsulosin, equal to 400 μg, increases the rate of urination and reduces the muscle tone of the urethra and prostate, thereby improving urinary outflow and reducing the negative symptoms of unstable bladder work. This effect of the drug leads to a decrease in the manifestations of irritation and obstruction associated with prostate adenoma, which persists even in the case of prolonged treatment.
Tamsulosin, like other antagonists of alpha1A-adrenergic receptors, is able to lower blood pressure by lowering the peripheral resistance, although at daily intake of 400 μg of tamsulosin there were no clinically significant cases of such decrease in blood pressure.
The drug form Omnic Ocas is a tablet with a controlled (slow) release of the active ingredient, based on a matrix using a non-ionic gel. The use of such a tablet provides a slow and long-term release of tamsulosin from it and its further sufficient exposure with a minimum fluctuation of plasma concentrations of the drug for 24 hours.
Absorption of tamsulosin from Omnic Ocas tablets occurs in the intestine, where approximately 57% of the dose of the drug is absorbed. Parallel food intake does not affect suction processes. Tamsulosin is characterized by linear pharmacokinetics. With oral intake of one tablet Omnic Ocas on an empty stomach, plasma Cmax of tamsulosin on average is observed after 6 hours. By the fourth day of taking the tablets, an equilibrium state of tamsulosin with its highest serum concentration is observed, after 4 to 6 hours after taking the drug, regardless of the meal. In this case, the plasma Cmax of the active ingredient is increased to 11 ng / ml, compared to a value of 6 ng / ml, noted after the first dose. The smallest serum content of the drug is 40% of its maximum plasma concentration. Among patients undergoing Omnic Ocas therapy, there are significant individual differences in plasma concentrations of tamsulosin after its single-dose and multiple-dose administration.
The binding of tamsulosin to plasma proteins occurs approximately 99%, Vd is approximately 0.2 l / kg.
Tamsulosin is characterized by slow metabolic changes in the liver with the release of less active products of metabolism of the active ingredient. In plasma, a significant majority of tamsulosin is in unchanged form. The preparation practically does not influence activity of hepatic microsomal enzymes.
The pathology of the liver does not require adjustment of the dosage regimen.
Tamsulosin, like the products of its metabolism, is mainly excreted by the kidneys, and by 4-6% the drug is excreted unchanged.
T1 / 2 single dose tamsulosin, with its peroral intake in the form of specially developed Omnic Ocas tablets, is approximately 19 hours, in equilibrium - 15 hours.

Indications for use

Appointment Omnic Ocas is indicated for the treatment of urinary disorders observed with prostate adenoma (prostate).

Contraindications

Absolutely contraindicated application Omnic Ocas with:
    severe hepatic failure;
    orthostatic hypotension;
    high personal sensitivity of the patient to tamsulosin or other ingredients of drugs.
Relative contraindications to the appointment Omnic Ocas are:
    arterial hypotension;
    impaired hepatic function;
    chronic failure of renal function (CC less than 10 ml / min).

Side effects

Sometimes during the therapy with capsules Omnic Ocas noted:
    asthenia;
    constipation;
    rhinitis;
    diarrhea;
    violation of ejaculation;
    nausea / vomiting;
    skin rash / itching;
    dizziness;
    occurrence of urticaria;
    headache;
    Quincke's edema (rarely);
    fainting (rarely);
    priapism (very rarely).
In the clinical practice of the drug, individual episodes of the formation of the narrow pupil syndrome were described in patients undergoing surgery for cataract.

Instructions for use Omnic Ocas

Instruction on Omnic Ocas recommends a single daily oral (oral) intake of 1 tablet of the drug (400 mcg), regardless of the time of ingestion. The duration of such a therapeutic course is not limited. This drug can be given as a continuous treatment. Take the pill completely (do not chew them to avoid a negative effect on the slow release of the active ingredient of the drug).

Overdose

Symptoms of overdose are most often expressed in the formation of compensatory tachycardia and lowering blood pressure.
In order to prevent further absorption of tamsulosin, it is advisable to carry out measures aimed at cleaning the digestive tract (enema, gastric lavage), as well as the internal reception of sorbents. The heart rate and blood pressure of the patient can recover independently when taking a horizontal position. In case of ineffectiveness of this method, consideration should be given to the use of therapeutic drugs that increase BCC, and, if necessary, to prescribe vasoconstrictors. It is necessary to control renal function at the entire stage of therapy of overdose states. Due to the intensive binding of tamsulosin to plasma proteins, its significant excretion during hemodialysis is unlikely.

Interaction

Jointly taken Amitriptyline, Warfarin, Diazepam, Simvastatin, Propranolol, Glibenclamide, Trichloromethiazide, Diclofenac and Chlormadinone do not change the free plasma fraction of tamsulosin (in vitro), nor does tamsulosin affect the free fractions of Chlormadinone, Trichloromethiazide, Propranolol and Diazepam.
With the parallel taking of other medications from the group of alpha 1-adrenergic blockers, it is possible to intensify the hypotensive effect.
A combination with cimetidine may result in a slight increase in the plasma content of tamsulosin, and with Furosemide, a decrease in plasma content. These changes do not require correction of dosages of the Omnic Ocas drug, since the plasma concentration of its active ingredient remains within the acceptable limits.
In an in vitro study of metabolic transformations taking place in the liver, no interaction of tamsulosin with finasteride, Glybenklamid, Salbutamol and Amitriptyline was noted.
The simultaneous administration of warfarin and diclofenac can speed up the rate of excretion of tamsulosin.
With the combined use of tamsulosin with Teofillin, Atenolol, Nifedipine, or Enalapril, no interactions were identified.

Terms of sale

You can buy Omnic Ocas without a prescription.

Storage conditions

Packages with the preparation should be stored at a maximum ambient temperature of 25 ° C.
Shelf life - 3 years.

special instructions

In the case of Omnic Ocas, an operative intervention on the organs of vision regarding cataract therapy, the appearance of the narrow pupil syndrome was sometimes observed, which must be taken into account by the surgeon for adequate preoperative preparation of the patient.
Before beginning therapy with Omnic Ocas, the patient should be referred for additional examinations, which should establish the presence or absence of other possible pathologies with identical prostatic adenoma with negative symptoms. Before starting taking the tablets and subsequently regularly throughout the treatment, the patient should be given a rectal finger examination and, if necessary, administer tests for the presence of a specific prostatic antigen.
With the withdrawal of tamsulosin treatment, there is no development of withdrawal syndrome.
Occasionally, in the presence of Omnic Ocas tablets, a sudden drop in blood pressure may occur, which can cause fainting. In this regard, with the first manifestations of orthostatic hypotension (feeling of weakness, a feeling of dizziness), the patient is recommended to sit or lie down and remain in it until all negative symptoms disappear.
In the case of identifying the patient's side effects of treatment, expressed in dizziness, he is recommended to refrain from driving and performing dangerous work.

Children

Due to the fact that problems with urination most often occur in adulthood, Omnic Ocas is not prescribed for children.

During pregnancy (and lactation)

Omnic Ocas tablets are indicated for use exclusively by men.

Reviews for Omnic Ocas

Doctors-urologists who use Omnic Ocas in their practice, in most cases remain satisfied with his action and in this regard leave positive feedback on the forums created to discuss the effectiveness and safety of this drug. The new pharmacological form of the drug, controlled release tablets, has a more stable effect, as compared to the capsules of the usual Omnica, and a lower incidence and severity of side effects, making this drug the preferred drug for patients with urinary problems.
Reviews of patients with regard to the action of Omnic Ocas tablets are not so positive, because in addition to the positive dynamics of the disease, they pay attention to the development of some negative effects, which interfere with normal life, among which are especially distinguished: a decrease in potency, ejaculation and lowering of blood pressure.