Sonizin caps 0.4mg #30

Sonizin user manual

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Composition

In 1 capsule of tamsulosin hydrochloride 0.4 mg. Calcium stearate, triethyl citrate, methacrylic acid-ethyl acrylate copolymer, talc, MCC, - as auxiliary substances.

Form of issue

Capsules with sustained release of 0.4 mg.

pharmachologic effect

Antidisuric.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Tamsulosin selectively blocks α1A-adrenergic receptors, which are located in the smooth muscles of the urethral part, passing in the prostate gland, the neck of the bladder, the prostate gland. It can be called a selective selective blocker, since α1A receptors are predominant in the prostate. Blocking these receptors causes a decrease in the tonus of the musculature of the above mentioned organs and as a result, the obstruction associated with the enlargement of the prostate gland decreases. The therapeutic effect in the form of improving the outflow of urine is observed after 2 weeks of administration, and in some patients after a single dose.
Its ability to block α1A-adrenoceptors several times exceeds the ability to act on α1B-adrenoreceptors located in the muscles of the vessels. Due to the high selectivity, there is no significant reduction in blood pressure.

Pharmacokinetics

When ingested completely absorbed from the gastrointestinal tract, therefore bioavailability is almost 100%. Cmax in plasma is determined after 6 hours. After 5 days of regular intake, Cmax in plasma is increased by 60-70%.
Binding to proteins is 99%. Slowly biotransformed in the liver, resulting in the formation of active metabolites, also having a selectivity for α1A-adrenergic receptors.
It is excreted by the kidneys. The half-life is 10 hours, the final time is 22 hours.

Indications for use

Disorders of urination with benign prostatic hyperplasia.

Contraindications

    orthostatic hypotension;
    hypersensitivity;
    marked hepatic and renal insufficiency;
    age to 18 years.

Side effects

The use of Sonizin can cause undesirable following reactions:
    heart beat, orthostatic and postural hypotension, rarely - tachycardia;
    constipation or upset of the stool, nausea, vomiting;
    dizziness, headache;
    violation of ejaculation, involuntary erection;
    Quincke's edema, skin rash, itching;
    rhinitis.

Sonizin, instructions for use (Method and dosage)

The drug is taken after eating 1 capsule daily, preferably at the same time. Capsule can not be broken, chewed or opened, as long-term release of the substance is disturbed. Drink plenty of water.

Overdose

It shows symptoms: a significant decrease in blood pressure, tachycardia.
Treatment begins with washing the stomach, taking Activated Carbon and laxative (osmotic), which prevents further absorption of the drug. The patient is given a horizontal position, vasoconstrictive agents are prescribed. The kidney function is monitored. Hemodialysis is ineffective.

Interaction

Furosemide slightly reduces the concentration of the drug in the plasma, which has no significant clinical significance.
Cimetidine increases the concentration of the drug in the blood.
Warfarin and Diclofenac and increase the rate of excretion.
Diazepam, Warfarin, Trichloromethiazide, Propranolol, Chlormadinone, Simvastatin, Amitriptyline, Glibenclamide do not change the free fraction of the active substance in the blood.
In vitro studies, no interaction with Amitriptylip, Glibenclamide, Salbutamol, and Finasteride has been established.
Simultaneous administration of inhibitors of acetylcholinesterase, anesthetics, diuretics, other alpha1-adrenoblockers, levodopa, alprostadil, antidepressants, beta-blockers enhances the hypotensive effect of tamsulosin.

Terms of sale

To buy Sonizin the prescription is not required.

Storage conditions

Storage temperature up to 30 ° C.
Shelf life - 3 years.

Reviews about Sonizin

Sonizin is an uroselective alpha-adrenoblocker of a new generation that alleviates the symptoms of the disease and reduces the likelihood of relapse. The drug does not affect the size of the prostate, but only eliminates the obstacles to urine movement. As a result, the incidence of urine in the excretory ducts of the gland decreases and inflammation is not maintained.
Improves the condition of patients with chronic prostatitis, which is observed from the second week of treatment. Important advantages are good tolerability, the possibility of simultaneous application with the main groups of drugs used to treat adenoma, the lack of influence on blood pressure.
There are not so many reviews of the drug, and they are contradictory:
"... after taking several pills, urination improved at times !!!"
"I drink a month. I did not notice any special effect, but my rhinitis was tortured "