Zalain cream 2% 20gr

Zalain user manual

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Composition

1 gram of cream contains 20 mg of sertaconazole nitrate.
In addition: 20000 mg of ethylene glycol palmitostearate and polyethylene glycol, 5000 mg of saturated polyglycolized glycerides, 2000 mg of glycerol isostearate, 8000 mg of paraffin oil, 100 mg of sorbic acid, 100 mg of methyl p-hydroxybenzoate, up to 100,000 mg of purified water.
1 suppository includes 300 mg of sertaconazole nitrate.
In addition: 1305 mg of a suppository, 1305 mg of Witepsol, 90 mg of colloidal anhydrous silicon dioxide.

Form of issue

The medicine Zalain is made in the form of 2% cream of 20 grams in a tube, placed in a cardboard box and in the form of suppositories (candles) 1 piece in a blister placed in a cardboard box.

pharmachologic effect

Local antifungal.

Pharmacodynamics and pharmacokinetics

Suppositories and ointment Zalain are an antifungal medication, the active ingredient of which is a derivative of benzothiophene and imidazole. Local application of therapeutic dosages of the drug is characterized by fungicidal and fungistatic efficacy. The central mechanism of action is aimed at suppressing the processes of ergosterol synthesis and increasing the permeability of mycosis cell membranes, which is actually the cause of lysis of the fungal cell.
The antifungal activity of the preparation extends to strains of fungi of the genus Candida. Antibacterial efficacy is evident in gram-positive microorganisms (Staphylococcus and Streptococcus).
In the case of topical application, sertaconazole nitrate is not detected either in the patient's blood or in his urine. When intravaginal use is not observed absorption of the active ingredient of the drug.

Indications for use

Cream Zalain is indicated for use in the treatment of superficial cutaneous mycoses, including: mycosis of brushes, feet and shins; mycosis beard; mycoses of the trunk; colored lichen; candidiasis.
Zalain suppositories are prescribed for local therapy of infections of the vaginal mucous membranes provoked by strains of the fungi of the genus Candida (thrush / candidiasis vulvovaginitis).

Contraindications

The use of all dosage forms of the drug is contraindicated if the patient has a personal hypersensitivity to any imidazole derivatives (including sertaconazole) or additional ingredients of drugs.

Side effects

When using the cream, sometimes the formation of local reactions manifested in the form of contact dermatitis was noted. Also, it is possible to develop rapid-flowing erythematous phenomena that do not require discontinuation of treatment.
Suppositories from the thrush occasionally led to allergic manifestations, as well as burning sensations in the vagina, which did not need to cancel the drug and disappeared on further therapy. These side effects are classified as classical effects observed with the use of local vaginal dosage forms, and reflect the effectiveness of the drug.

Instructions for use Zalain

Cream Zalain, instructions for use

Proper use of the cream involves its uniform application of a thin layer on the infected skin areas, with the capture of about 1 cm of healthy skin around the problem area. The recommended frequency of application of the drug is 2 times in 24 hours, with the duration of therapy depending on the etiology of the causative agent and infectious localization (most often 4 weeks). Disappearance of symptoms of infection, usually seen after 2-4 weeks.
Do not recommend the use at the same time of other local antifungal drugs (ointments, solutions, gels, etc.).

Suppositories Zalain, instructions for use

Vaginal suppositories of the drug are intended for single use. One, previously extracted from the blister Suppository, should be inserted deep into the vagina. This procedure is recommended to perform before bedtime in a horizontal (lying on the back) position of the body. If the negative symptoms of thrush are preserved, you can repeat the procedure of administering the suppository after a lapse of 7 days.
Immediately before the introduction of the Suppository should be hygiene of the external genitalia, using an alkaline or neutral soap.

Overdose

Given the external use of both dosage forms of the drug, an overdose of their active ingredient is unlikely. In case of accidental ingestion of a cream or suppository, the stomach must be immediately cleaned (vomiting, washing) and, if necessary, symptomatically treated.

Interaction

During the application of the cream, it was not revealed its clinically significant interaction with other therapeutic agents.
In the case of using local contraceptives at the time of application of candles, it is possible to reduce the spermicidal effect of contraceptives.

Terms of sale

To buy Zalain you don't need a prescription.

Storage conditions

The maximum possible ambient storage temperature of the cream is 25 ° C, this indicator for candles is 30 ° C.
Shelf life - 3 years from the time they are produced.

special instructions

The cream of the drug is not intended for use in ophthalmic practice.
When applying the cream, the use of acidic hygiene products should be avoided, due to the increased reproduction of Candida fungus strains in an acidic environment.
In case of therapy with suppositories with concurrently observed infectious lesions of the labia and the nearest parts of the skin (candidiasis vulvitis), additional local application of Zalain cream is recommended.
Allow the introduction of suppositories during menstruation.
At the time of the therapeutic action of the suppository sex is not desirable.
In order to prevent urogenital reinfection, parallel therapy of the sexual partner should be considered.
The possibility of damage to contraceptive barrier means (rupture of the diaphragm or condom) increases during the action of the active ingredient in the Suppository.

Children

The lack of reliable data on the effects of Zalain in pediatrics allows the use of this drug for the treatment of children only when appointed by a pediatrician and under strict control.

Zalain during pregnancy (and lactation)

The instruction to the drug allows the use of Zalain cream and suppositons during pregnancy and lactation, only after an individual's assessment of the risk / benefit ratio for a woman / child (fetus), which is confirmed by both positive and negative reviews about Zalain during pregnancy and lactation of women, when or treated with this drug. It is impossible to foreknew and accurately predict the response of the female body to the action of the active ingredient of the drug and its effect on the fetus / child, so in these periods it is better to do without the use of "chemistry".

Zalain Reviews

In comparison with other creams and ointments having such an antifungal effect, reviews about Zalain cream are noticeably more positive. Many patients who have experienced several similar local drugs, put the best evaluation of the effectiveness, duration and safety of Zalain and recommend this cream to all of their friends who suffer from the same infectious diseases.
Reviews of Zalain candles are also generally positive in most cases and often speak of effective treatment of thrush using only one suppository. In turn, comparing drugs analogues in terms of safety and frequency of recurrence of infection and relying on their own experience, some women advise to use these candles in pregnancy, but caution against the independent appointment of such treatment in favor of the mandatory decision of the possibility of antifungal therapy by a doctor.