Synaflan ointment 0.025% 15gr

Synaflan buy online

Instruction for Synaflan

Composition

The composition of 1 g of liniment or ointment includes 0.25 mg of the active ingredient.
As auxiliary ingredients in liniment there are:
    propylene glycol;
    anhydrous lanolin;
    petrolatum;
    pentanol;
    stearic acid;
    nipagin;
    nipazel;
    purified water.
Excipients in the composition of ointment:
    benzyl alcohol;
    propylene glycol;
    soft white paraffin;
    ceresin;
    lanolin.

Form of issue

Produced in such dosage forms:
    Ointment of Synaflan. A homogeneous consistency is characteristic. Color from light yellow to saturated yellow.
    Liniment is light yellow in color.
    Cream of Synaflan.
    Gel Synaflan.
Both liniment and ointment are placed in aluminum tubes of 10 g and 15 g. Each tube is placed in a separate cardboard pack.

pharmachologic effect

Refers to glucocorticosteroids. Apply externally to eliminate inflammation, allergic reactions, itching.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

It is often possible to hear the question of whether hormonal hormone is Synaflan or not. This hormonal drug, but this is due to its high efficiency.
Fluorocinolone acetonide binds to specific receptors of the cytoplasm of cells, which provokes increased synthesis of mRNA. The result of exposure affects all metabolic processes in the cell.
From clinically significant effects, we can name such aspects of the effect on the cell:
    inducing the synthesis of lipocortic proteins, including lipomodulin, which leads to inhibition of the activity of phospholipase A2, which is one of the factors in the progression of the inflammatory reaction;
    stabilizes the cell membrane, which helps prevent edema;
    increases the rate of protein catabolism;
    reduces the migration of B- and T-lymphocytes and disrupts the interaction of these cells;
    inhibits the accumulation of leukocytes and macrophages at the site of inflammation;
    suppresses the action of hyaluronidase, reduces the level of formation of arachidonic acid, leukotrienes;
    affects the regulation of carbohydrate metabolism, reducing the consumption of glucose by tissues, which can lead to an increase in its concentration in the blood;
    promotes the retention of sodium and water ions, provokes the excretion of potassium and calcium, reduces the ability to assimilate calcium;
    increases the synthesis of erythropoietins.
Such influence on metabolic processes in the cell contributes to a noticeable effect in those cases for which the medicine is used - from acne and other inflammatory skin lesions.

Pharmacokinetics

Fluocinolone acetonide easily penetrates all layers of the skin, but accumulates in the stratum corneum (can be detected even after 15 days after completion of treatment). In the bloodstream gets in a small amount.
Biotransformation occurs in the liver. In this case, inactive metabolites are formed. Excretion occurs mainly due to the work of the kidneys.
Absorption of the drug occurs more intensively in the case of treatment of children, applying to large areas of the skin, with regular application, applying to the skin of the face or damaged skin.

Indications for use

Why use Synaflan Ointment and dosage forms of the drug? For the treatment of various inflammatory skin lesions of non-infectious etiology.
From what ointment Synaflan helps in most cases? You can list such indications for the use of ointment, gel, cream and liniment:
    eczema of different localization;
    psoriasis of the body and scalp;
    atopic dermatitis;
    seborrheic lesions;
    red flat lichen;
    itching of the skin of an unknown etiology;
    discoid form of lupus erythematosus;
    allergic rashes;
    erythema multiforme;
    minor burns;
    neurodermatitis;
    inflammation in the place of an insect bite.

Contraindications

It is forbidden to use ointment or liniment in such cases;
    hypersensitivity to the active ingredient or auxiliary components of the drug;
    skin diseases caused by an infectious agent: a bacterium, a virus or a fungus;
    lupus;
    skin lesions, a manifestation of syphilis;
    wound surface;
    diaper rash;
    precancerous skin conditions, tumors;
    Presence of a nevus on a site of a skin where it is necessary to put a medicine;
    psoriasis, which progressed to the formation of plaques;
    acne (application of Synaflan from acne, which in fact are blackheads, can cause an exacerbation of the disease);
    trophic ulcers on the lower limbs, caused by varicose veins;
    any application for children under 2 years;
    The use in ophthalmology and on the skin of the mammary glands is prohibited;
    pregnancy and lactation.

Side effects

The question of whether hormonal ointment or not, is often due to the fact that it is known that hormonal drugs are actively affecting the entire body. This applies to Synaflan. Side effects are not very common, but they can be quite diverse.
From the skin and subcutaneous fat can appear:
    urticaria;
    allergic contact dermatitis;
    irritation of the skin;
    peeling skin or rashes in the form of papules or spots on the site of application of the medicine;
    hyperkeratosis;
    furunculosis;
    exacerbations of the pathological conditions of the skin that were present at the time of treatment;
    atrophic changes in the skin;
    burning;
    itching;
    steroid acne;
    folliculitis;
    loss of hair or excessive growth in the area of ​​application of Synaflan;
    disorders of pigmentation.
From the side of the digestive system (it happens when applied on large areas of the skin):
    gastritis;
    steroid stomach ulcer.
From the endocrine organs:
    increased blood glucose levels;
    glucosuria;
    in children, a slowdown in growth and development;
    when applied to large areas of the skin, it is possible to develop adrenal insufficiency, Isenko-Cushing syndrome, steroid diabetes.
From the side of immunity:
    allergic reactions;
    hypersensitivity reactions;
    decreased immunity;
    exacerbation of chronic diseases;
    generalization of infectious lesions;
    slowing the process of repair.
From the side of the heart and blood vessels:
    increased blood pressure;
    swelling.
When applied to the outer surface of the eyelids, there is a risk of developing cataracts and glaucoma.

Instructions for use Synaflan (Method and dosage)

Ointment Synaflan, instructions for use

Ointment is applied to the affected area 1 or 2 times a day, lightly rubbed. The course of treatment in adults - up to 10 days, for children - not more than 5 days, for the face skin - no more than 1 day.
It is undesirable to use the ointment under the bandage, except for some forms of psoriasis. But in this case it is very important to regularly change it.
The drug in the form of an ointment is recommended for use in dry forms of dermatoses.

Liniment Synaflan, user's manual

Liniment can be applied 2-4 times a day. The course of treatment is the same in duration, as when using ointment.
Do not use under a closed bandage, but can be applied to a small area of ​​the skin under the occlusal.
It is desirable to use in dry dermatoses.

How to apply Cream or gel Synaflan

Apply to affected areas 1-4 times a day. The course lasts no more than 2 weeks.
The cream is more often used in wet dermatoses, and the gel is used in case of skin lesions of the scalp.

Overdose

Overdosing can easily occur when applying the medicine over large areas of the skin, in the case of prolonged treatment or applying to particularly sensitive areas, for example, the skin of the face. Also a high risk in the treatment of children with Synaflan.
Possible symptoms of overdose:
    swelling;
    increased blood pressure;
    burning, itching at the site of application;
    increased blood and urine glucose levels;
    syndrome Itenko-Cushing.
Treatment for overdose is symptomatic. At the same time, the gradual abolition of Synaflan is shown.

Interaction

The drug interacts with many other medicines, so caution is necessary when using concomitantly:
    with glucocorticosteroids of systemic action - increases the effectiveness of Synaflan and the likelihood of developing side effects from its use;
    with non-hormonal anti-inflammatory drugs - increases the risk of developing both local and systemic unwanted reactions of the body to each of the drugs;
    with antihypertensive, antarrhythmic drugs, diuretics, potassium preparations - the effectiveness of these medicines decreases;
    with diuretics (except potassium-sparing) - the likelihood of developing hypokalemia increases;
    with vaccines - an inadequate immune response is possible due to the fact that the immunity is weakened and is unable to synthesize the necessary antibodies in a normal amount;
    with immunosuppressors - enhances the effect;
    with immunostimuljatoryami - suppresses influence of these medicines on immune system.

Storage conditions

Keep in a cool place, but do not allow freezing.

Shelf life

Ointment is stored for 5 years, liniment 2 years.

special instructions

When treating Synaflan it is necessary to adhere to such recommendations:
    Avoid contact with eyes;
    Do not apply to wounds, skin of the mammary glands;
    it is strictly forbidden to exceed the recommended duration of treatment;
    Do not use with other topical medicines;
    it is undesirable to use under a bandage as in that case adsorption of a medicine and risk of development of systemic by-effects increases;
    If necessary several times to undergo a course of treatment, you need to take tests to monitor the functioning of the adrenal glands.

Children

It is forbidden to use before the age of 2 years.
After 2 years, Synaflan is prescribed for children with caution, for a short time and only under the supervision of a doctor.
When used in the treatment of children, it is prohibited to apply the medicine to the skin of the face.

In pregnancy and lactation

It is forbidden to use during pregnancy and lactation, as there is not enough research on the effect of the drug on the baby's body.

Reviews of Synaflan

Reviews about the ointment Synaflan and other dosage forms of this drug are in most cases positive. It turns out to be very effective, it acts quickly, but is inexpensive.
Among the shortcomings are called the fact that the drug is hormonal and it is undesirable to use it for the treatment of children. Some patients were faced with the fact that the body quickly got used to the drug and in subsequent applications the effect was lower.