Artrosilene spray 15% 25ml

Artrosilene spray instruction

You can buy Artrosilene spray here

pharmachologic effect

Artrosilene spray has anti-inflammatory, analgesic, antipyretic effects.
Possesses anti-bradykinin activity, stabilizes lysosomal membranes and delays the release of enzymes from them, contributing to the destruction of tissues during chronic inflammation. Reduces cytokine secretion, inhibits neutrophil activity.
Reduces morning stiffness and swelling of joints, increases range of motion.
Ketoprofena lysine salt, unlike ketoprofena, is an instant compound with a neutral pH, due to which it almost does not irritate the gastrointestinal tract.
When applied externally, Artrosilene spray reduces the manifestations of inflammation and pain in the affected joints, tendons, ligaments, muscles. In case of articular syndrome, it causes a reduction in pain in the joints at rest and during movement, a decrease in morning stiffness and swelling of the joints.
Ketoprofena lysine salt has no catabolic effect on articular cartilage.

Indications

    relief of pain of low and moderate intensity, incl. postoperative pain; post-traumatic and inflammatory pain;
    rheumatic diseases such as:
    rheumatoid arthritis;
    spondyloarthritis;
    osteoarthritis;
    gouty arthritis;
    inflammatory lesion of periarticular tissues.

Contraindications

    hypersensitivity, incl. to other NSAIDs;
    Aspirin asthma;
    pregnancy (III trimester);
    lactation period;
    stomach ulcer and duodenal ulcer in the acute phase, peptic ulcer;
    ulcerative colitis in the acute phase, Crohn's disease;
    diverticulitis;
    hemophilia and other coagulation disorders;
    chronic renal failure;
    children's age up to 18 years.

Use during pregnancy and lactation

The use of the drug Artrosilene spray in the third trimester of pregnancy is contraindicated. In the I and II trimesters of pregnancy, the drug spray Artrosilene should be used with caution and under the supervision of a physician.
If necessary, the use of the drug during lactation breastfeeding should be discontinued.
Women planning a pregnancy should refrain from taking the drug Artrosilene spray, because against the background of its reception, the probability of implantation of an egg cell may decrease.

special instructions

During treatment with the drug Artrosilene spray, it is necessary to periodically monitor the pattern of peripheral blood and the functional state of the liver and kidneys.
If necessary, determine the 17-ketosteroids drug should be canceled 48 hours before the study.
Taking Artrosilene spray may mask signs of an infectious disease.
The use of spray Artrosilene in bronchial asthma can provoke an attack of suffocation.
When applied externally, the drug should be applied only to intact skin. Avoid contact with eyes and mucous membranes. In order to avoid manifestations of hypersensitivity and photosensitivity, it is recommended to avoid exposure of the skin to sunlight during the course of treatment.
Application for abnormal liver function If abnormal liver function requires dose reduction.
Application for violations of renal function In case of violation of renal function, a dose reduction is necessary.
Impact on the ability to drive vehicles and control mechanisms During the period of use of the drug should refrain from potentially hazardous activities that require high concentration of attention and speed of psychomotor reactions.

Composition

1 g of spray contains etoprofen lysine salt 150 mg
Dosage and administration
When applied topically, a single dose of aerosol is 1-2 g (walnut volume).
The drug should be applied 2-3 times / day, gently rubbing until completely absorbed. The duration of treatment should not exceed 10 days (without consulting a doctor).

Side effects of Artrosilene spray

Nervous system: dizziness, hyperkinesia, tremor, vertigo, mood swings, anxiety, hallucinations, irritability, general malaise.
Sense organs: conjunctivitis, blurred vision.
Skin: urticaria, angioedema, erythematous exanthema, pruritus, maculo-papular exanthema, increased sweating, erythema multiforme exudative (including Stevens-Johnson syndrome).
Urinary system: painful urination, cystitis, edema, hematuria, menstrual disorders.
Organs of hematopoiesis: leukocytopenia, leukocytosis, lymphangitis, decrease in PV, thrombocytopenia, thrombocytopenic purpura, increase in the size of the spleen, vasculitis.
Respiratory system: bronchospasm, dyspnea, sensation of spasm of the larynx, laryngospasm, laryngeal edema, rhinitis.
Cardiovascular system: hypertension, hypotension, tachycardia, chest pain, syncopal states, peripheral edema, pallor.
Allergic reactions: anaphylactoid reactions, swelling of the oral mucosa, pharyngeal edema, periorbital edema.

Drug interaction

Inductors of microsomal oxidation in the liver (including phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) with simultaneous use with the drug Artrosilene increase the metabolism of ketoprofen (increase the production of hydroxylated active metabolites).
Against the background of simultaneous use with the drug Artrosilene spray, the effectiveness of uricosuric drugs decreases, the effect of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of mineralocorticoids, glucocorticoids, estrogens increases; reduces the effectiveness of antihypertensive drugs and diuretics.
The simultaneous use of the drug Artrosilene spray with other NSAIDs, GCS, ethanol, corticotropin can lead to the formation of ulcers and the development of gastrointestinal bleeding, to an increased risk of developing impaired renal function.
The simultaneous appointment of Artrosilene spray with oral anticoagulants, heparin, thrombolytic agents, antiplatelet agents, cefoperazone, cefamandol and cefotetanom increases the risk of bleeding.
The drug Artrosilene spray with simultaneous use enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is necessary).
Joint appointment Artrosilene spray with sodium valproate causes a violation of platelet aggregation.
Ketoprofen with simultaneous use increases the plasma concentration of verapamil and nifedipine, lithium, methotrexate.
Antacids and colestiramine while ingesting with the drug Artrosilene spray reduce the absorption of ketoprofen.

Overdose

Currently, no cases of overdose with Artrosilene spray have been reported.
In case of overdose, symptomatic therapy, monitoring of respiratory and cardiovascular activity should be carried out. There is no specific antidote. Hemodialysis is ineffective.

Storage conditions

The drug should be stored in a dark place, out of the reach of children at a temperature up to 25 ° C.
Shelf life - 3 years.

Terms of sell

To buy Artrosilene spray the prescription is not required.