Diartrin caps 50mg #30

Diartrin instruction for use

You can buy Diartrin here

Indications for use

Symptomatic treatment of osteoarthrosis of the hip and knee joints.

Contraindications

Hypersensitivity to diacerein, other components of Diartrin or anthraquinone derivative; inflammatory bowel disease (ulcerative colitis, Crohn's disease); intestinal obstruction; abdominal pain of unknown origin; patients with liver disease (including history); severe renal failure (creatinine clearance less than 30 ml / min); deficiency of lactase, lactose intolerance, glucose-galactose malabsorption; pregnancy and the period of breastfeeding; children's age till 18 years.
With caution apply the drug for renal failure of moderate severity (creatinine clearance 30-60 ml / min), irritable bowel syndrome, as well as in patients 65 years of age and older.

Dosing and Administration (Instruction)

Diartrin is taken orally, after eating, swallowing whole, with water, 50 mg (1 capsule) 2 times a day (morning and evening).
Treatment is conducted continuously for a long time or courses lasting at least 4 months.
Since diacerein during the first two weeks can cause acceleration of transit in the intestine, it is recommended to start treatment with 1 capsule per day (in the evening, during meals) for four weeks. Then, after consulting a doctor, the dose can be increased to 100 mg (2 capsules) per day.
In patients with moderate renal insufficiency (creatinine clearance 30-60 ml / min), the dose of the drug should be reduced by half to 50 mg (1 capsule) per day.

Pharmachologic effect

The active substance Diartrin - diacerein - anthraquinoline derivative, diacetylated derivative of rhein. Metabolized to the active metabolite of rhein, inhibits the activity of interleukin-1, which plays an important role in the development of inflammation and cartilage degradation in osteoarthritis.
Diacerein inhibits the effects of other cytokines, including interleukin-6, tumor necrosis factor-alpha. The action develops in 2-4 weeks.
Diacerein has analgesic and anti-inflammatory activity when taken orally.

Side effects of Diartrin

The frequency of unwanted reactions is as follows: very often (> 1/10 cases), often (> 1/100 and <1/10 cases), infrequently (> 1/1000 and <1/100 cases), rarely (> 1 / 10000 and <1/1000 cases) and very rarely (<1/10000 cases, including individual cases).
Allergic reactions: infrequently - allergic reactions of varying degrees, rash, itching.
From the digestive system: rarely - diarrhea, nausea, vomiting, abdominal pain.
Other: infrequent - intensive staining of urine1, rarely - general malaise.
1 - During treatment with the drug, intensive coloration of urine (depending on pH) from yellow to brown color is possible, which is not clinically important and does not require drug withdrawal or dose reduction.
If any of the unwanted reactions listed in the manual is aggravated, or if you notice other undesirable reactions not listed in the instructions, inform your doctor.
Diarrhea overdose may cause diarrhea, weakness. Symptomatic treatment is indicated. With severe diarrhea, it is necessary to replenish the water-electrolyte balance.

Special instructions

The duration of treatment can be long. Before the therapeutic effect, Diartrin can be taken concomitantly with analgesic drugs (including non-steroidal anti-inflammatory drugs).
During treatment, periodic monitoring of blood counts, functional tests of the liver, urine is necessary.
If the kidney function worsens, the doctor must decide whether to reduce the dose or to cancel it.
Staining of urine may make it difficult to interpret the results of the urinalysis (for example, on the glucose content).
When a patient has diarrhea, Diartrin's treatment should be discontinued.
The effect of the drug on the concentration of attention, the speed of psychomotor reactions in the management of vehicles, mechanisms and employment of other potentially hazardous activities has not been studied.

Interaction

Antacids reduce the absorption of diacerein.
At the same time taking with drugs that affect the intestinal microflora (including antibiotics), as well as with substances that change the quality of the contents of the intestine and the rate of its emptying (for example, fiber), the frequency of undesirable reactions from the digestive system can increase.
Drugs containing aluminum hydroxide and / or magnesium hydroxide, reduce the bioavailability of diacerein.
The simultaneous use of Diartrin with laxatives is not recommended.

Terms of sell

To buy Diartrin you don't need a prescription.