Dilaxa caps 200mg #30

Dilaxa instruction for use

You can buy Dilaxa here

The composition and release form of Dilaxa

Hard gelatin capsules No. 1, brownish-yellow; the contents of the capsules are white or almost white granular powder.
1 caps
celecoxib 200 mg
Excipients: croscarmellose sodium 1.35 mg, magnesium stearate 2.7 mg.
The composition of the gelatin capsule: titanium dioxide 1%, iron dye oxide yellow 1%, gelatin to 100%.

pharmachologic effect

NSAIDs. It is a selective inhibitor of COX-2, thereby blocking the formation of inflammatory prostanoids.
At therapeutic concentrations in humans, celecoxib does not inhibit COX-1, therefore, it does not affect prostanoids synthesized by activating COX-1.
Criteria for determining specificity with respect to COX-2 include no side effects caused by COX-1, especially ulcerative lesions of the stomach and duodenum, serious complications of the upper GI tract (bleeding, perforations, obstruction of the pyloric orifice) and the absence of COX inhibition. -2-dependent platelet aggregation activity.

Indications

Dilaxa is used for symptomatic treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis.

Contraindications for Dilaxa

Severe renal dysfunction, severe liver dysfunction; allergic reactions to taking acetylsalicylic acid or other NSAIDs in history, III trimester of pregnancy, lactation (breastfeeding); hypersensitivity to sulfonamides, hypersensitivity to celecoxib.

Dosage

When Dilaxa ingested for adults, the dose is 200 mg / day in 1-2 doses, if necessary - 200 mg 2 times / day.
Elderly patients with a body weight of less than 50 kg or with moderate abnormal liver function treatment should begin Dilaxa with the minimum recommended dose.
There is no clinical experience with celecoxib in patients with severely impaired liver or kidney function.

Side effects of Dilaxa

Since the cardiovascular system: often - peripheral edema; sometimes - aggravation of arterial hypertension, increased blood pressure, arrhythmia, hot flashes, palpitations, tachycardia; rarely - a manifestation of congestive heart failure, ischemic stroke and myocardial infarction.
On the part of the digestive system: often - abdominal pain, diarrhea, dyspepsia, flatulence, diseases of the teeth (postextraction alveolar alveolitis); sometimes vomiting; rarely - gastric and duodenal ulcer, esophageal ulceration, intestinal perforation, pancreatitis, increased activity of liver enzymes; there are reports - gastrointestinal bleeding, hepatitis, liver failure.
On the part of the central nervous system and peripheral nervous system: often - dizziness, increased muscle tone, insomnia; sometimes - anxiety, drowsiness; rarely - confusion, hallucinations, aseptic meningitis.
From the urinary system: often - urinary tract infection; there are reports of acute renal failure interstitial nephritis.
On the part of the respiratory system: often - bronchitis, cough, pharyngitis, rhinitis, sinusitis, infections of the upper respiratory tract.
Dermatological reactions: often - pruritus, skin rash; sometimes - alopecia, urticaria; there are reports - photosensitization, peeling of the skin (including with erythema multiforme and Stevens-Johnson syndrome), toxic epidermal necrolysis, acute generalized exantmatous pustus.
From the hemopoietic system: sometimes - anemia, ecchymosis, thrombocytopenia.
On the part of the senses: sometimes - tinnitus, blurred vision; rarely - loss of taste, loss of smell.
On the part of the reproductive system: there are messages - a violation of the menstrual cycle.
Allergic reactions: rarely - angioedema, bullous eruptions; There are messages - anaphylaxis, vasculitis.
On the part of the body as a whole: often - exacerbation of allergic diseases, flu-like syndrome, accidental injuries.

Drug interaction

With simultaneous use Dilaxa with drugs that inhibit the activity of CYP2C9 isoenzyme, incl. with fluconazole, a significant increase in plasma celecoxib concentration is possible. Antacids (aluminum and magnesium) reduce celecoxib absorption by 10%, which does not cause clinically significant effects. The simultaneous use of celecoxib with warfarin increases the risk of bleeding.

special instructions for Dilaxa

Caution Dilaxa should be used in patients with heart failure and other conditions predisposing to fluid retention. Use Dilaxa in patients with gastric ulcer or duodenal ulcer is possible only in the case of complete remission of the disease; with severe renal and hepatic failure - only in exceptional cases.
There is no clinical experience with celecoxib in patients with severe impaired liver or kidney function, as well as in patients younger than 18 years of age.

Pregnancy and lactation

Adequate and strictly controlled studies of the safety of celecoxib during pregnancy have not been conducted, so the use is not recommended.
If necessary, use Dilaxa during lactation should decide on the termination of breastfeeding.
In experimental studies not detected toxic effects on the fetus; It is shown that in animals the concentration of celecoxib in breast milk is close to that in plasma.

In case of impaired renal function

Dilaxa contraindicated in severe renal impairment.

With abnormal liver function

Contraindicated in severe violations of the liver.

Terms of sell

You canbuy Dilaxa without a prescription.