Celebrex 200mg #10

Celebrex instruction

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Celebrex capsules are a non-steroidal anti-inflammatory drug that has high specificity in suppressing the activity of the cyclooxygenase-2 (COX-2) enzyme. They are used to reduce the severity of the pain syndrome of predominantly inflammatory origin.

Description of dosage form, composition

Celebrex capsules have a white color, a hard gelatinous shell, inside they contain small granules of white color. The main active ingredient of the drug is celecoxib, its content in one capsule can be 200 and 400 mg. It also includes auxiliary components, which include:
    Croscarmellose sodium.
    Water ammonia.
    Ethanol.
    Gelatin.
    Propylene glycol.
    Lactose monohydrate.
    Isopropanol.
    Magnesium stearate.
    Sodium lauryl sulfate.
Celebrex capsules are packaged in a blister for 10 pieces. A cardboard pack contains 1 or 3 blisters with capsules, it is equipped with a control of the first autopsy, and also has an annotation to this medication.

Pharmacological effects, pharmacokinetics

The main active ingredient of Celebrex capsules suppresses the activity of the enzyme cyclooxygenase-2 (COX-2, which is produced by the cells of the immune system during the development of the inflammatory process and catalyzes the reaction of the conversion of arachidonic acid to prostaglandin inflammation mediators.These biologically active compounds lead to the development of signs of inflammation, which include pain, swelling of the tissues and their hyperemia.As the drug blocks the enzyme COX-2, its main pharmacological effect is yavl etsya decrease prostaglandin concentration in the hearth of the pathological process and signs of inflammatory reaction, especially pain. Also, the drug has anti-inflammatory and analgesic therapeutic effect.
After taking the capsule Celebrex inside the active ingredient quickly enough and almost completely absorbed into the systemic circulation. It is evenly distributed in tissues, penetrates the blood-brain barrier into the structures of the central nervous system. Celecoxib is metabolized in the liver with the formation of inactive decay products, which are excreted from the body with urine.

Indications

The reception of Celebrex capsules is indicated for the treatment of various inflammatory pathologies, as well as reducing the severity of the pain syndrome:
    Back pain.
    Pain after surgery.
    Symptomatic treatment aimed at reducing the severity of inflammation in the pathology of the structures of the musculoskeletal system is rheumatoid arthritis (autoimmune joint damage), osteoarthritis (degenerative-dystrophic joint damage accompanied by the development of an inflammatory reaction).
Also, the drug is used to treat primary algodismenorea in women (menstruation, accompanied by severe pain).

Contraindications

A number of pathological and physiological conditions of the patient's body are distinguished, under which Celebrex capsules are prohibited, these include:
    Inflammatory bowel pathology.
    Ulcerous pathology or peptic ulcer of the stomach, duodenal ulcer in the stage of exacerbation.
    Severe renal or hepatic insufficiency.
    Condition after aortic coronary artery bypass surgery.
    The expressed insufficiency of the functional activity of the heart.
    Confirmed ischemic heart disease, peripheral arterial disease, or cerebrovascular pathology.
    Confirmed patient sensitivity to drugs of the pharmacological group sulfonamides.
    Specific allergic reactions (bronchial asthma, urticaria), developing after the use of aspirin or other drugs of the pharmacological group, non-steroidal anti-inflammatory drugs.
    Hypersensitivity to the active ingredient or auxiliary compounds of this drug.
    Pregnancy at any time of the course, as well as the period of breastfeeding (lactation).
    The patient is under 18 years old.
With caution, the drug is used after the ulcerative pathology of the gastrointestinal tract, as well as against the remission of the pathological process (improvement of clinical and laboratory indicators of the disease), the joint use of drugs anticoagulants and antiaggregants, which reduce blood clotting, diabetes, heart and vascular diseases , cerebrovascular pathology, severe somatic pathology, peripheral arterial pathology. Before taking Celebrex capsules, it is important to make sure there are no contraindications.

Dosage

Celebrex Capsules are intended for oral administration regardless of food. They are not chewed and washed down with enough water. To reduce the likelihood of development of negative pathological reactions, in particular from the cardiovascular system, it is recommended to apply the drug in a minimum effective therapeutic dosage and a small course. If a longer treatment is necessary, the maximum daily dosage of Celebrex capsules should not exceed 400 mg. The regimen of medication, as well as the average therapeutic dosage depends on the medical indications:
    Osteoarthritis - the recommended therapeutic dosage is 200 mg per day in 1 or 2 doses.
    Ankylosing spondylitis - 200 mg per day in 1 or 2 admission, if necessary in case of insufficient therapeutic effect, the dosage can be increased to 400 mg per day.
    Rheumatoid arthritis - the recommended dose, depending on the therapeutic effect achieved, varies from 100 to 200 mg per day.
    Pain syndrome of different origin, algodismenorea in women - the primary dosage is 400 mg per day, then it is reduced to 200 mg in 1 or 2 doses.
For elderly patients, patients with concomitant moderate decrease in the functional activity of the kidneys or liver, dosage adjustment is usually not required. With the joint use of drugs that are actively metabolized in the liver (fluconazole), usually a reduction in the therapeutic dose of the drug is required. The duration of the course of treatment in most cases is determined by the doctor individually.

Side effects

Against the backdrop of the course of therapy conducted with the use of Celebrex capsules, it is possible to develop negative pathological reactions from various organs and systems:
    The digestive system - abdominal pain, diarrhea, bloating (flatulence), less likely to develop vomiting, peptic ulcer, and possibly the development of gastrointestinal bleeding, especially when using the drug against the stomach ulcer or duodenal ulcer, inflammation of the liver (hepatitis ).
    Cardiovascular system - development of peripheral edema, worsening of the course of arterial hypertension (increase in the level of systemic arterial pressure), symptomatic increase in pressure, increased heart rate (tachycardia), the appearance of palpitations and tides in the face, less likely to develop ischemic stroke of the brain or infarction myocardium.
    The nervous system - periodic dizziness, increased muscle tone, the development of insomnia, less likely to appear anxiety, drowsiness, confusion, impaired sense of smell and taste changes, hallucinations.
    The respiratory system is the inflammation of the bronchial mucosa (bronchitis), the appearance of a cough, the pathological inflammatory reaction in the pharynx (pharyngitis), the nasal cavity (rhinitis), the paranasal sinuses (sinusitis), the development of infectious processes that are localized in the upper respiratory tract.
    The urinary system - the development of infectious processes in the urinary tract, rarely marked inflammation of the kidneys (interstitial nephritis).
    Skin and its appendages - cases of hair loss (alopecia), development of hypersensitivity to the light with its subsequent inflammation (photodermatitis) have been reported.
    Allergic reactions - a rash on the skin, its itching, characteristic changes resembling a nettle burn (urticaria), pronounced swelling of soft tissues in the face and external genital organs (angioedema angioedema), a systemic reaction with a pronounced decrease in systemic arterial pressure, and the development of a multi-organ insufficiency (anaphylactic shock). Less often there were cases of severe allergic skin damage with the death of its cells (Stevens-Johnson syndrome, Lyell).
If there are signs of side effects, Celebrex capsules should be discontinued and you should seek help from a doctor who will individually identify the possibility of further use of this medication.

Features of use

Prior to the appointment of Celebrex capsules, the doctor must carefully read the instructions and draw attention to a number of specific instructions regarding the correct use of this medication:
    Since the drug has antipyretic pharmacological action, then against its background, it is possible to erroneously diagnose the presence of infectious processes in a patient with fever.
    Against the background of using this drug for a long time and at high therapeutic dosages, the risk of developing a cardiovascular catastrophe, including myocardial infarction, cerebral stroke, is significantly increased.
    The risk of developing a cardiovascular catastrophe is significantly increased when the drug is used to treat the pain syndrome in patients after an operation of aorto-coronary shunting.
    The drug does not affect the functional state of platelets, so unlike acetylsalicylic acid, it can not be used to prevent thrombosis.
    Celebrex capsules can cause an increase in the level of systemic blood pressure, so it is recommended to periodically monitor it.
    The drug has not a pronounced negative effect on the gastrointestinal tract, nevertheless, against the background of its use, cases of ulcerative pathology of the stomach and duodenum, bleeding, and perforation (the formation of a through hole) of the walls of the hollow structures of the digestive tract are not ruled out. More often such reactions can take place in elderly or weakened patients.
    The drug has a negative effect on the functional state of the liver, kidneys, can lead to the development of peripheral edema.
    Celebrex capsules can interact with drugs from other pharmacological groups, so they should be warned about their possible use by a doctor.
    It is not recommended to use this medication for pregnant women and breast-feeding women.
    The active component of this drug does not affect the functional state of the nervous system.
In the pharmacy chain, Celebrex capsules are prescription-dispensed. To avoid the development of complications or negative health consequences, their independent use is not recommended.

Overdose

To date, clinical experience regarding the development of symptoms after taking high doses (about 2 g) of Celebrex capsules is limited. In the case of a significant excess of the dose, gastric and intestinal washing is performed, and if necessary, symptomatic therapy is prescribed. Hemodialysis (hardware blood purification) with regard to this medication is ineffective.

Shelf life, storage

The shelf life of Celebrex capsules is 3 years. They should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of +15 to +30 ° C.