Nemulex granules 100mg #30

Nemulex instruction

Reed more and buy Nemulex

Composition

One packet of the drug Nemulex contains 100 mg of Nemulex.
Additional substances: citric acid, macrogol cetostearate, sucrose, silicon dioxide, orange flavor.

Form of issue

Yellow granules for making a suspension for internal administration, the finished suspension has a pale yellow color. 100 mg of granules in a multi-layer bag - two, four, six, ten, twenty or thirty bags in a cardboard bundle.

pharmachologic effect

Anti-inflammatory, analgesic, antiplatelet, antipyretic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Non-steroidal anti-inflammatory drug. Has anti-inflammatory, antipyretic, analgesic and antiplatelet effect. Selectively inhibits cyclooxygenase of the second type, inhibits the biosynthesis of prostaglandins in the inflammatory region; has a weakly depressing effect on the first type of cyclooxygenase (even more rarely causes unwanted effects associated with suppression of prostaglandin biosynthesis in healthy cells).

Pharmacokinetics

When taken orally, the degree of absorption is high. The time of the greatest concentration reaches 2.5 hours.
Reactions with plasma proteins are 95% and do not have a dose-dependent character. Actively penetrates into the synovial fluid and the focus of inflammation. Easily penetrates through any gistogematicheskie barriers.
It is transformed in the liver with the participation of monooxygenases. The main metabolite is 4-hydroxynimidesulide, it is inclined to undergo enterohepatic recirculation. The elimination half-life is 1.7-4.8 hours. It is excreted in urine and bile.

Indications for use

    osteoarthritis;
    rheumatoid arthritis;
    arthritis of diverse etiology;
    myalgia;
    arthralgia;
    postoperative and post-traumatic pain;
    tendonitis;
    bursitis;
    algodismenorea;
    headache and toothache.
The drug does not affect the progression of the disease.

Contraindications

    Lesions of the mucous membranes of the duodenum and stomach of an erosive-ulcerative nature.
    The combination of recurrent polyposis of the nasal cavity, bronchial asthma and intolerance to Aspirin and other non-steroidal anti-inflammatory drugs.
    Active bleeding of gastrointestinal localization.
    Diseases of the intestine are inflammatory in the phase of exacerbation.
    Cerebrovascular or other bleeding.
    Hemophilia and other disorders of blood coagulability.
    Hepatic insufficiency or liver disease in the active phase.
    Decompensated heart failure of a chronic type.
    Hepatotoxic effects when using Nemulex in the past.
    Severe renal failure of a chronic type.
    Alcoholism, drug addiction.
    Progressive kidney disease.
    Condition after aortocoronary shunting.
    Confirmed hyperkalemia.
    Sensitization to the components of the preparation.
    Joint reception of other hepatotoxic agents.
    Pregnancy and lactation.
    Age is less than 12 years.
It should be used with caution in patients with coronary heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia, peripheral arterial disease, diabetes mellitus, renal insufficiency, susceptibility to ulceration, the presence of Helicobacter pylori, concomitantly with the use of anticoagulants, antiplatelet agents, oral glucocorticosteroids , serotonin reuptake blockers, in elderly patients.

Side effects

    Reactions from the digestive side: nausea, diarrhea, vomiting, flatulence, constipation, gastritis, stomatitis, abdominal pain, tarry stool, bleeding, ulcer of the duodenum or stomach, jaundice, increased levels of "liver" transaminases, fulminant hepatitis, cholestasis.
    Reactions from the nervous activity: a sense of fear, dizziness, nervousness, headache, drowsiness, nightmares, encephalopathy.
    Allergic reactions: urticaria, angioedema, hypersensitivity reactions, facial swelling, anaphylactoid reactions.
    Reactions from the skin: skin rash, itching, increased sweating, dermatitis, erythema, exudative erythema multiforme, epidermal toxic necrolysis.
    Reactions from the genitourinary sphere: dysuria, edema, hematuria, oliguria, hyperkalemia, urinary retention, interstitial nephritis, renal insufficiency.
    Reactions from hematopoiesis: eosinophilia, anemia, thrombocytopenia, purpura, pancytopenia, lengthening of bleeding.
    Reactions from the eyes: vision damage.
    Reactions from the side of breathing: bronchospasm, shortness of breath.
    Reactions from the circulation: tachycardia, arterial hypertension, hot flashes, hemorrhages.
    Other reactions: weakness, hypothermia.

Instructions for the use of Nemulex (Method and dosage)

Instructions for use Nemulex prescribes to dissolve the contents of one sachet in 100 ml of water.
The recommended dosage for patients from 12 years is 100 mg twice a day after eating. The largest daily dose for patients from 12 years is 200 mg.
Patients with renal failure need to reduce the daily dose to 100 mg.
To reduce the risk of adverse reactions, the agent should be given at the lowest effective dose for the shortest possible time. The maximum duration of drug use is 15 days.

Overdose

Signs of an overdose: nausea, vomiting, drowsiness, bleeding of gastrointestinal localization, apathy, increased pressure, acute renal failure, respiratory depression.
Therapy: symptomatic treatment. There is no selective antidote. Persons admitted to the hospital with signs of overdose with a remedy are advised to perform gastric lavage and receive activated charcoal and osmotic laxative. Continuous monitoring of kidney and liver parameters is also necessary.

Interaction

Nemulex is able to compete for binding to plasma proteins with salicylic acid, Fenofibrate, Tolbutamide, and lower the bioavailability of Furosemide.
In the presence of the drug, the concentrations of Methotrexate may increase greatly in a free form.
The concentration of lithium in the blood increases with the joint intake of lithium-containing agents and Nemulex.
Nemulex increases the effect of Ciclosporin on kidney tissue.
It is not recommended to take the drug together with diuretics that have a negative effect on hemodynamics in the tissues of the kidneys.
When combined with glucocorticosteroids, serotonin reuptake blockers, the probability of bleeding from the digestive tract increases.

Storage conditions

Store in a dry, dark place at room temperature. Keep away from children.
Shelf life - 4 years.

special instructions

If the patient's condition does not improve, therapy should be discontinued.
You also need to stop using the drug with fever, the appearance of influenza-like symptoms, symptoms that indicate liver damage, kidney damage, and the development of gastric bleeding against its background.
In case of using the drug for more than two weeks, it is necessary to monitor the liver function.
If the drug causes side effects from the nervous system and sensory organs, the patient is advised to refrain from controlling mobile mechanisms.

Children

Not used in children under 14 years of age.

In pregnancy and lactation

In these periods, as well as during pregnancy planning from the use of the drug should be discarded.

Reviews of Nemulex

Reviews about Nemulex on forums and among doctors do not differ from reviews about other Nemulex-containing drugs. These drugs have proven themselves for joint and bone pain, as well as for traumatic pain syndrome.
Nemulex often causes reactions from the digestive organs, including ulceration and hepatonecrosis, so it (like other preparations based on Nemulex) is banned in many countries of Western Europe.