Cetirizine drops 10mg/ml 20ml

Cetirizine user manual

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Composition

In one tablet - cetirizine dihydrochloride 10 mg. MCC, silicon dioxide, lactose monohydrate, magnesium stearate, as an auxiliary component.
In 1 ml drops - cetirizine dihydrochloride 10 mg. Benzoic acid, propylene glycol, glycerol, water, sodium acetate, as auxiliary substances.

Form of issue

    Tablets in the shell of Cetirizine Teva 10 mg.
    Drops Cetirizine Hexal for oral administration in vials of 10 ml or 20 ml.

pharmachologic effect

Antiallergic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The H1-histamine receptor blocker, a competitive histamine antagonist. Eliminates the manifestations of allergic reactions, possessing antiexudative and antipruritic action. Reduces the permeability of capillaries, eliminates spasm of muscles and skin reaction (with cold urticaria). Reduces the hyperreactivity of the bronchopulmonary system in patients with asthma in response to the release of histamine.
Almost no anticholinergic and sedative effect. The effect is observed after 1 hour, the maximum of action is determined after 4 hours, and the duration is 24 hours. The action lasts 3 days after the end of treatment. Against the background of treatment, tolerance to the action of the drug does not develop.

Pharmacokinetics

When ingested well absorbed. C max is determined in the blood after 1 h. It binds to proteins by 93%. Do not cumulate. Metabolized to an inactive metabolite, 60% excreted by the kidneys in 96 hours and a small part of the active substance (10%) - through the intestine. T1 / 2 is 7-10 hours. T1 / 2 in children 6-12 years - 6 hours. There is an increase in T1 / 2 if the kidney and liver function is impaired.

Indications for use

Symptomatic treatment:
    seasonal and year-round rhinitis and conjunctivitis;
    chronic urticaria;
    dermatoses with the presence of itching (dermatitis, neurodermatitis).

Contraindications

    hypersensitivity;
    age up to 6 years (for tablets);
    pregnancy;
    lactation;
    severe renal failure;
    glucose-galactose malabsorption;
    lactose intolerance.
It is used with caution in severe renal failure, in old age, while taking barbiturates, ethanol, opioid analgesics, benzodiazepine derivatives. During the reception period, avoid transport management.

Side effects

More common side reactions:
    diarrhea;
    paresthesia;
    excitation;
    itching, rash;
    asthenia.
Rarely encountered adverse reactions:
    tachycardia, palpitations;
    accommodation disorders;
    increased level of liver transaminases;
    hepatitis;
    hives;
    angioedema;
    dysuria;
    difficulty urinating;
    weight gain;
    motor disorders;
    aggression;
    depression;
    insomnia;
    hallucinations;
    a taste disorder;
    fainting;
    thrombocytopenia.

Instructions for use Cetirizine (Method and dosage)

Drops Cetirizine Hexal, instructions for use

Adults and children from the age of 12 prescribe 20 drops (which corresponds to 10 mg), preferably in the evening. Children 6 -12 years - 20 drops in the evening, from 2 to 6 years - 10 drops in the evening, 1 to 2 years 5 drops 2 times a day.
Elderly patients do not change the dose. With renal failure, the recommended dose is reduced by 2 times. With liver failure, the dose is selected individually. Duration of treatment with seasonal allergic rhinitis 3 - 6 weeks. If the flowering of plants is not prolonged, and the pollen acts briefly - one week.

Instructions for use Cetirizine Teva

Tablets are taken orally, whole, better in the evening, given the sedative effect. Adults and children from 12 years of age are prescribed 10 mg per day. Children 6-12 years with a weight of more than 30 kg - 10 mg 1 time per day, with weight less than 30 kg - 5 mg once a day.

Overdose

Overdose is manifested by drowsiness in adults, in children with anxiety and irritability, with a delay in urination, constipation, dry mouth, dilated pupils, tachycardia.
Treatment consists in washing the stomach and administering enterosorbents. Symptomatic treatment is performed. There is no antidote. Hemodialysis is not effective.

Interaction

Interactions with cimetidine, erythromycin, ketoconazole, diazepam, and azithromycin were not detected. Application with Teofillin reduces the clearance of cetirizine. Myelotoxic drugs increase the hematotoxicity of cetirizine. Care must be taken when using drugs that oppress the central nervous system.
The drug enhances the effects of alcohol, so taking it is not permissible during treatment with this drug. The use of cetirizine should be discontinued three days before allergic tests are performed.

Terms of sale

You can buy Cetirizine without a doctor's prescription.

Storage conditions

Storage temperature up to 25 ° C.
Shelf life - 3 years.

Cetirizine in Pregnancy

The official instruction states that the drug is contraindicated in pregnancy. This is based on the fact that proper studies of women in this category have not been conducted, however animal studies have not revealed the risks of adverse effects on the fetus (FDA risk category for FDA). Also, there is no data on its isolation with breast milk, so do not use it in the infant feeding period.
Nevertheless, according to a few studies of the drug regarding the possibility of using in pregnant women in the first trimester, it does not increase the number of congenital malformations, the frequency of spontaneous abortions and preterm labor. The weight of the newborns, whose mothers were taken by Cetirizine, did not differ either.
If there is a need to use antiallergic drugs during pregnancy, then weighing all the risks, the advantage should be given to Fenkarol, cetirizine and Loratadin, which it is better not to appoint in the first trimester.

Reviews about Cetirizine

From what tablets Cetirizine? This is an anti-allergic (antihistamine) drug of the second generation, which has a rapid onset of action and a long duration. The use of the drug is justified in cases where long-term treatment of allergic diseases is necessary: ​​chronic urticaria, all-the-year-round rhinitis.
Its characteristic feature is a high ability to penetrate the skin, so it is effective for skin manifestations of allergy - atopic dermatitis, hives, rashes of allergic genesis. Of all the drugs of the second generation, only Cetirizine is used in children from 6 months.
High affinity for histamine H1 receptors minimizes side effects. According to the patients' reviews, even prolonged use of the drug did not cause dryness in the mouth, nose, constipation. A number of drugs in this group have cardiotoxic effects, and Cetirizine, Ebastin, Loratadine, Acryvastin do not have such an effect.
Reviews about Cetirizine Hexal are positive, patients note its effectiveness, and importantly - the variety of forms of release. Parents note the great acceptability for children of the drug in the form of drops. In the pharmacy there is a large selection of dosage forms with the same active substance. Drops of cetirizine hydrochloride are available under the names Zirtek, Zodak, Pralazin, and in the form of syrup, Zerinal, Zetrin, Zincet are produced, which increases the possibilities of their use. With all this, the drug is regarded as a drug that has a sedative effect (which can not be said about Amertile), which limits its use.