Arutimol 0.5% 5ml

Arutimol user manual

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Composition

Timolol hydro-maleate, benzalkonium chloride solution, povidone, sodium dihydrogenphosphate dihydrate, sodium monohydrogenphosphate dodecahydrate, disodium edetate dihydrate, sterile water.

Form of issue

Eye drops 0.25% and 0.5% as a colorless transparent solution odorless in a polyethylene bottle 5 ml in a carton.

pharmachologic effect

Antiglaucomatous.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The preparation is antiglaucomal, belongs to the group of non-selective adrenoreceptor blocker β1 and β2. Does not have sympathomimetic and membrane stabilizing action. Local action of the drug is manifested by a decrease in intraocular pressure, while both increased and normal IOP decreases. This process occurs due to a decrease in the production of intraocular fluid. The drug does not influence the accommodation and the size of the pupil. The effect after instillation in the conjunctival sac appears after 30 minutes, reaches a maximum value after one hour is maintained throughout the day.

Pharmacokinetics

The drug with a local administration of systemic absorption is slightly affected. Cmax timolol in the aqueous environment of the anterior chamber of the eye after instillation comes after 2 hours. In the systemic blood stream, the active substance of the drug is absorbed in small amounts, absorbed through the vessels of the lacrimal tract, conjunctiva and mucous membranes. It is excreted in the urine in the form of metabolites.

Indications for use

    Eye hypertension, secondary glaucoma, open-angle glaucoma;
    In the combined treatment of closed-angle glaucoma, as an additional drug for reducing IOP in conjunction with miotics);
    Treatment of congenital glaucoma in cases of insufficient effectiveness of other drugs.

Contraindications for Arutimol

COPD, bronchial asthma, heart failure, age under 18, pregnancy and lactation, allergic reactions to the drug, cardiogenic shock, atrophic rhinitis, dystrophic processes in the cornea, sinus bradycardia. Use with caution in diabetes mellitus, cerebrovascular insufficiency, thyrotoxicosis, hypoglycemia, Raynaud's syndrome, myasthenia gravis.

Side effects

They are manifested as general reactions (fast fatigue, nausea, diarrhea, disorientation and weakness, bradycardia, respiratory disorders, bronchospasm, hypotension, blepharitis, keratitis, conjunctivitis, rhinitis, allergic reactions, hallucinations, and local (congestion hyperemia and irritation, itching and burning in the eyes, photophobia, lacrimation, superficial keratopathy, corneal edema, diplopia, urticaria).

Arutimol, instructions for use (Method and dosage)

Bury eye drops Arutimol 0.25% or 0.5% 1 drop in the conjunctival sac 2 times a day. After a decrease in IOP, they switch to a maintenance dosage - 1 drop of 0.25% solution once a day. Treatment is long with minor interruptions.

Overdose

In rare cases, the appearance of systemic effects, which are typical when taking drugs, beta-adrenoblockers: headache, dizziness, bradycardia, nausea, vomiting, lowering blood pressure, arrhythmia, bronchospasm, heart failure.

Interaction

Simultaneous administration of the drug with eye drops, which contain epinephrine and pilocarpine, increases the risk of pupil dilated. With the joint administration of arutimol with reserpine, calcium channel blockers and beta adrenoblockers, a decrease in blood pressure and a slowing of the heart rate may be potentiated. Simultaneous reception with insulin or hypoglycemic agents can cause hypoglycemia. Timolol potentiates the therapeutic effect of muscle relaxants, it is necessary to cancel it two days before surgery under general anesthesia.

Storage conditions

At temperatures up to 25 ° C. Eye drops in the opened bottle are suitable for use for 6 weeks.
Shelf life - 3 years.

Reviews about Arutimol

Reviews about the drug among patients are favorable. "... I am treated with Arutimol for almost 2 years with interruptions. With his help, while maintaining intraocular pressure, although the doctor offers a laser correction. " In practice, Arutimol is often used in hemangiomas, especially in hemangiomas in infants in their primary manifestations and small in size.