Oftan Timolol 0.5% 5ml

Oftan Timolol user manual

You can buy Eye drops Oftan Timolol here

Composition

Eye drops contain 2.5 or 5 mg of Timolol maleate + excipients (sodium phosphate, 2-aqueous, mono-substituted, sodium hydroxide, benzalkonium chloride, disodium 12-hydrous sodium phosphate, water).

Form of issue

The drug is released in vials of 5 ml, in a cardboard pack of 1 vial with a dispenser-dropper. Contents vials - a solution without color and odor, transparent. Oftan Timolol is released in two dosages, 2.5 or 5 ml of the active substance in 1 ml of the agent.

pharmachologic effect

Antiglaucomatous.

Pharmacodynamics and pharmacokinetics

The active component of Oftan Timolol is the L-isomer of timolol, available as a maleate salt. The substance belongs to the group of non-selective beta-adrenoreceptor blockers. This isomer is similar to the beta-1 and beta-2 receptors. Due to this, the drug is able to reduce the intraocular pressure, due to a decrease in the intensity of production of the liquid.
With topical application, the product penetrates directly into the ciliary tissue, where moisture production takes place. It is still not completely clear whether timolol affects the blood vessels in the anterior segment of the eye, but with reduced intraocular pressure, there are improvements in the blood circulation of the retina.
The effect of taking the medicine lasts a very long time, up to a day. Sympathomimetic activity and membrane-stabilizing effect of the substance does not possess. The drug does not affect the accommodation and the size of the pupil, does not cause dependence (withdrawal syndrome does not arise).
The active substance is readily soluble in fats, so it quickly enters the target tissues through the conjunctival vessels and the nasal mucosa. After 3-4 hours after taking the maximum concentration and effect of the drug is achieved. The action lasts about a day.
A drug is produced with streams of watery moisture flowing out of the eye. The half-life is 8 hours. That part of the substance that has penetrated into the systemic bloodstream (for example, through the stomach or the walls of blood vessels) undergoes metabolic reactions in the liver tissues, inactive metabolites are excreted through the kidneys. The half-life from plasma is 4 hours, the degree of binding to proteins is 60%. The medicine is able to overcome the blood-brain barrier.

Indications for use

Oftan Timolol appoint:
    for the treatment of various types of glaucoma (open-angle, glaucoma on the aphakic eye, other types of secondary glaucoma);
    at a closed angle glaucoma (as part of complex therapy with miotics);
    with increased intraocular pressure;
    with congenital glaucoma, if other therapeutic measures are not effective enough.

Contraindications of Oftan Timolol

The medicine is not prescribed:
    when allergic to the components of the product;
    if the patient has heart failure;
    at a bronchial asthma and other diseases of respiratory ways;
    up to 18 years;
    with sinus bradycardia;
    with atrioventicular blockade of the second or third degree.

Care should be taken:

    with other diseases of the lungs and heart;
    with diabetes mellitus;
    with thyrotoxicosis or hypoglycemia;
    myasthenia gravis;
    when the drug is combined with other drugs of the same group (beta-blockers).

Side effects

The risk of adverse reactions depends on the degree of penetration of the drug into the blood plasma and the presence of chronic diseases in the patient.

The following local reactions were observed:

    discomfort and pain in the eyes, dryness, redness;
    sensation that there is a foreign body in the eye, photophobia, erosion of the cornea of ​​the eye;
    hypotension, decreased corneal sensitivity, keratopathy;
    conjunctivitis (including allergic), blepharoconjunctivitis, hyperemia;
    deterioration of vision clarity, superficial spotted keratitis;
    exfoliation of the choroid, contact dermatitis of the eyelids, blepharoptosis, hemorrhages in the retina, diplopia, ptosis, keratitis.

Reactions of a systemic nature:

    allergy, anaphylactic shock;
    shortness of breath, cessation of breathing, cough, cyanosis, dyspnea, nasal congestion, bronchial asthma;
    bradycardia, lowering blood pressure, arrhythmia, congestive heart failure, cerebral infarction, pain in the sternum, collapse, stroke, cerebral vascular ischemia, extrasystole;
    weakness, headache, and a premature condition, a sense of fear, asthenia;
    nausea, diarrhea, indigestion;
    hallucinations, depression, psychosis, insomnia and nightmares, paresthesia, apathy;
    weight gain, hyperglycemia, hormonal imbalance;
    urticaria, rashes on the skin, baldness, stomatitis, allergic dermatitis, Lyell's syndrome, eczema.
Also, side effects associated with oral administration of timolol or other beta-blockers (Raynaud's disease, purpura, sweating, Peyronie's disease, arthralgia, tinnitus, ischemic colitis, difficulty urinating, etc.) can rarely occur.
If adverse reactions appear, take the medication and consult a doctor.

Instruction on Oftan Timolol (method and dosage)

The drug is conjunctival.
As a rule, appoint 1 or 2 drops, 2 times a day. After the improvement, the daily dosage can be reduced to 1 drop per day.
The course of treatment is appointed by the attending physician.

Overdose

When an overdose can develop symptoms that are characteristic of beta-blockers: headache, nausea, bronchospasm, vomiting, arrhythmia, dizziness.
In case of accidental ingestion, dyspnoea, dizziness, nausea, diarrhea, vomiting, disturbance of the heart rhythm, general weakness can be observed inside.
In case of an overdose, rinse immediately with clean water or fiz. solution, to produce symptomatic therapy.
In case of ingestion:
    stop receiving;
    rinse the stomach;
    apply (depending on the symptoms) dopamine, noradrenaline, glucagon, atropine or isoprenaline hydrochloride;
    if there is a need, you can install an artificial pacemaker;
    therapy with digitalis, diuretics.

Interaction

Due to the joint administration of the drug with insulin or other anti-diabetic drugs hypoglycemia may develop.
The combination with adrenaline can cause a strong dilatation of the pupils.
Simultaneous reception of nicardipine, diltiazem and medication can lead to increased intraocular pressure.
It is not recommended to combine Oftan Timolol with pilocarpine.
When combined with calcium antagonists, reserpine, cardiac glycosides, beta-blockers, there may be a significant decrease in blood pressure, AV blockade and a slowing of the heart rate.
Timolol can enhance the action of muscle relaxants. The gap between the opening of funds should be at least 48 hours.
Enzymes P450, CYP2D6 take part in the metabolism of timolol, therefore it is not recommended to take other agents, in the metabolism of which the same enzymes (quinidine) participate.
When combined with epinephrine, mydriasis may develop.
The interval between taking clonidine and timolol should be at least two days.
Cimetidine is able to enhance the therapeutic effect of the drug.

Terms of sale

You don't need a prescription.

Storage conditions

Store drops recommended in a cool place, at a temperature of 15 to 30 degrees. Avoid getting into the hands of young children.
Shelf life - 3 years.
After opening the vial the drug can be used for a month.

special instructions

The safety and effectiveness of the use of funds in children have not been established.
When treating the drug should be regularly examined by an ophthalmologist, monitor intraocular pressure, the condition of the cornea, blood and lacrimation.
If you cancel the drug in people with hyperthyroidism or thyrotoxicosis, you should be careful, monitor blood glucose levels.
After applying the drug, in order to avoid its penetration into the systemic blood flow, it is recommended to close the eyes and press the nasolacrimal canal with a finger for 120 seconds.
In patients with closed-angle glaucoma, the drug must be combined with various miotics to achieve the desired therapeutic effect.
The interval between the reception of various drugs should be at least 15 minutes.
When wearing contact lenses while taking medication, they should be removed and put on not earlier than 15 minutes.
When taking the drug is not recommended to drive a car or perform high-precision or high-speed response operation.

In pregnancy and lactation

The drug is not recommended for use by pregnant and lactating women. His reception at an early date (before the second trimester) is unacceptable. Breastfeeding should be discontinued.

Reviews

Reviews for Oftan Timolol little. Of those that are available, mostly good. Some want to accelerate the process of gradual decrease in intraocular pressure by increasing the daily dosage. Adverse reactions with compliance with the dosing regimen are rare.