Azarga eye drops 5ml

Instruction for Azarga

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Composition

The formulation contains active ingredients: Brinzolamide and Timolol.
Additional constituents: mannitol, sodium chloride, disodium edetate, purified water, sodium hydroxide, benzalkonium chloride 50%, tyloxapol.

Form of issue

Produced Azarga in the form of drops of the eye, packaged in 5 ml in the bottles of a dropper.

pharmachologic effect

Eye drops Azarga have a combined effect.

Pharmacodynamics and pharmacokinetics

The effect of this drug causes the substances in its composition. In combination, the effectiveness of each component is significantly increased. Brinzolamide is characterized by inhibition of carbonic anhydrase II, as a result of which the formation of bicarbonate ions slows down, leading to a decrease in the transport of sodium as well as liquid. This reduces the production of intraocular fluid inside the ciliary body of the eye, which helps to reduce intraocular pressure.
A non-selective beta-adrenergic blocker, timolol, does not have sympathomimetic activity. In this case, the drug does not show undesirable effects on the myocardium, without exerting a membrane-stabilizing effect. The local application of eye drops helps to significantly reduce the intraocular pressure by reducing the formation of moisture and increasing its outflow.
The use of drops leads to the penetration of the main components into the systemic circulation. The connection with plasma proteins can be 60%. As a result of metabolism, several metabolites are formed. Excretion from the body predominantly occurs with the help of the kidneys in an unchanged form, the rest in metabolites.

Indications for use

The main indication for the appointment of eye drops Azarga is the need to reduce high intraocular pressure in the treatment:
    open-angle glaucoma;
    intraocular hypertension, when the other therapy was not effective enough.

Contraindications

The drug is not recommended for:
    bronchial asthma;
    hyperreactivity of the bronchi;
    sinus bradycardia;
    chronic obstructive pulmonary disease;
    AV-blockade;
    severe heart failure;
    cardiogenic shock;
    severe allergic rhinitis;
    renal failure;
    simultaneous use of oral inhibitors of carbonic anhydrase;
    angle-closure glaucoma;
    lactation, pregnancy;
    children under the age of 18;
    hypersensitivity to the drug and the means of his group.
Care is needed in the treatment of patients with hyperthyroidism, arterial hypotension, Prinzmetal angina, circulatory disorders.

Side effects

When treating with eye drops Azarga possible the development of local reactions and systemic side effects. Especially often are: blurred vision, pain and irritation, sensation of foreign particles in the eyes, dysgeusia, keratitis, keratopathy, defective epithelium of the cornea, increased intraocular pressure, formation of defects and deposits on the cornea, corneal edema, apathy, depression and so on.
Treatment requires immediate rinsing of the eyes with clean water. Then, symptomatic and supportive treatment is performed. At the same time, it is necessary to control the level of electrolytes and pH in the blood.

Azarga, instructions for use (Method and dosage)

Eye drops are for local use. Before use, the vial should be shaken well. The medicine is instilled daily with one drop of 2 in each conjunctival sac.
To reduce the risk of systemic undesirable effects after instillation, it is recommended to easily push your finger at the location of tear sacks closer to the inner corner of the eye. This action reduces the systemic absorption of the drug.
In case of missing the dosage, the treatment should be continued with the next dose according to the established schedule, not exceeding the dose. When switching to Azarga treatment with another drug after its withdrawal, you should start dripping this medicine only the next day.

Overdose

There were no cases of overdose.

Interaction

At the moment, the interaction of eye drops with Azarga and other drugs has not been studied. It is not recommended to simultaneously use oral inhibitors of carbonic anhydrase, so as not to increase systemic side reactions.
Also, one should refrain from the combination with ketoconazole, itraconazole, clotrimazole, ritonavir and troleandomycin, to prevent inhibition of the metabolism of brenzolamide.
Strengthen the hypotensive effect or cause pronounced bradycardia with combinations with calcium channel blockers, guanethidine, antiarrhythmics, beta-blockers, some cardiac glycosides, and so on.
When drops are applied simultaneously with other ophthalmologic agents for topical application, it is necessary to maintain an interval of 15 minutes.

Storage conditions

Drops should be stored at room temperature, out of the reach of children.
Shelf life - 2 years.

Reviews about Azarga

Practically all the reviews about Azarga indicate the high effectiveness of this drug, which allows to reduce intraocular pressure and maintain visual acuity. However, many patients report the development of side effects, due to which they were forced to stop treatment.
According to patients who underwent eye operations, as a result of treatment, their intraocular pressure normalized, but unwanted systemic reactions, for example insomnia, began, and then the pressure became even lower than normal.
In addition, there are reports of local reactions in the form of eye irritation. Although some patients try to endure for a while, but gradually the condition only worsens. Therefore, experts do not recommend conducting such experiments, as this can cause tissue damage.
Also, users are confused by the relatively high cost of the drug. For this reason, sometimes patients who are helped and well suited to these drops simply can not afford to buy them because of the inaccessible price.
It should be noted that glaucoma is a rather complex disease requiring regular treatment. If the specialist has prescribed drops of Azarga, but the patient can not buy them, you should immediately tell the doctor who can appoint an adequate replacement, but cheaper in cost.