Travoprost drops 0.04mg/ml 2.5ml

Travoprost user manual

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pharmachologic effect

Antiglaucomatisant. Synthetic analogue of prostaglandin F2α.
It is a highly selective agonist of prostaglandin FP receptors. Reduces intraocular pressure due to increased uveoscleral outflow of aqueous humor.
Intraocular pressure decreases approximately 2 hours after application of the drug, the maximum effect is achieved after 12 hours.

Pharmacokinetics

Travoprost is absorbed through the cornea of ​​the eye, where hydrolysis of Travoprost occurs to a biologically active form - Travoprost acid. Cmax of Travoprost in blood plasma is reached within 30 minutes after topical application and is 25 pg / ml or less. Travoprost is quickly removed from the plasma, within an hour the concentration drops below the detection threshold (<10 pg / ml). It is excreted as inactive metabolites mainly with bile (61%), the rest is excreted by the kidneys.

Indications

Reduction of increased intraocular pressure with open-angle glaucoma, increased ophthalmotonus.

Dosing regimen

Instilled 1 drop into the conjunctival sac of the affected eye (eye) 1 time / day, preferably in the evening.

Side effects of Travoprost

From the side of the organ of vision: very often - a transient weakly expressed congestion hyperemia, passing alone; often a decrease in visual acuity, a feeling of discomfort and foreign body, pain, itching, burning in the eyes, visual disturbances, blepharitis, fog before the eyes, cataracts, conjunctivitis, dry conjunctiva, changes in color of the iris, keratitis, crust formation on the edges of the eyelids, photophobia, subconjunctival hemorrhages and increased lacrimation.
From the cardiovascular system: often - increase or decrease in blood pressure, bradycardia, angina pectoris, chest pain, hypercholesterolemia.
From the side of the central nervous system: often - general anxiety, headache, depression.
From the urinary system: often - urinary incontinence and urinary system infection.
From the musculoskeletal system: often - arthritis, back pain.
Other: often - flu-like syndrome, sinusitis, bronchitis, dyspepsia.

Contraindications for use

Children and adolescents under 18 years of age, hypersensitivity to Travapress.

Application in pregnancy and lactation

Use during pregnancy is contraindicated.
There is no sufficient experience in lactation. Application during the period of breastfeeding is possible only under the supervision of a doctor and only if the potential benefit of therapy for the mother exceeds the possible risk of side effects for the infant.

Use in children

Contraindicated in children and adolescents under 18 years.

special instructions

With caution apply in the presence of risk factors for the development of macular edema (aphakia, pseudofakia, damage to the posterior capsule of the lens), with acute iritis, uveitis.
Against the background of the application, it is possible to gradually change the color of the eyes by increasing the amount of brown pigment in the iris. This effect is revealed mainly in patients with mixed iris color, for example, blue-brown, gray-brown, green-brown or yellow-brown, which is explained by the increase in melanin content in the stromal melanocytes of the iris. Typically, brown pigmentation spreads concentrically around the pupil to the periphery of the iris of the eyes, while the entire iris or parts of it can acquire a more intense brown color.
In patients with uniformly colored eyes of blue, gray, green or brown, eye color changes after two years of use of the drug were very rare. The color change is not accompanied by any clinical symptoms or pathological changes.
After the abolition of therapy, there was no further increase in the amount of brown pigment, but the already developed color change may be irreversible.
Before starting treatment, patients should be informed about the possibility of changing eye color.
Treatment of only one eye can lead to permanent heterochromia.
In the presence of nevi or lentigo on the iris, their changes were not observed under the influence of Travoprost.

Travoprost can cause darkening, thickening and lengthening of eyelashes and / or an increase in their number; rarely - darkening of the skin of the eyelids.
Can be used in combination with other antiglaucoma drugs for topical use. In this case, the interval between their use should be at least 5 minutes.
When wearing contact lenses before instillation of the lens should be removed and installed back no earlier than 20 minutes after the procedure.

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