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Avodart caps 0.5mg #90

  • $121.62
  • 2 or more $119.80
  • 3 or more $117.50
  • Availability:In Stock

Avodart instruction for useReed more and buy Avodart on this pageCompositionIn a single capsule of medicine: dutasteride 0.5 mg + additional ingredients (butylhydroxytoluene, gelatin, titanium dioxide, triglycerides, mono-diglycer..

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Avodart instruction for use

Reed more and buy Avodart on this page


In a single capsule of medicine: dutasteride 0.5 mg + additional ingredients (butylhydroxytoluene, gelatin, titanium dioxide, triglycerides, mono-diglycerides of caprylic acid, glycerin, iron oxide black, red ink for printing, lecithin).

Form of issue

The drug is released in the form of yellow matte opaque capsules. Each capsule is printed with red ink GX CE2. In cardboard boxes of 30 or 90 pieces (10 in a blister, 3 or 9 blisters in a package).

pharmachologic effect


Pharmacodynamics and pharmacokinetics

The active component of the agent is a double inhibitor of the enzyme 5-alpha-reductase. The substance inhibits the conversion of testosterone to DHT by suppressing the activity of 5-alpha-reductase 1 and type 2. After all, dihydrotestosterone is responsible for the development of hyperplasia. Thus, the size of the prostate gland decreases, urination normalizes, the probability of cure without surgery is increased.
The higher the dose of the drug taken, the more it affects the production of DHT. Its maximum effect is achieved in one to two weeks, after the start of treatment.
The maximum concentration of the drug in the blood serum is reached approximately 1.5 hours after administration. Bioavailability is 60% (compared to intravenous administration). Eating does not affect the performance.
The drug has a very high degree of binding to plasma proteins, about 99%. About 11.5% of the active ingredient with a systematic long-term admission gets into the sperm.
In a living organism, Avodart is extensively metabolized. Excretion of 1-15% of the substance occurs through intestines in unchanged form, 74% make up 4 large metabolites, 5% - other small metabolites. Completely out of the body the drug is withdrawn about a month after the end of admission. However, even after 6 months, its insignificant amount can be detected in serum.
In elderly patients there was no significant change in any pharmacokinetic parameters. From this it follows that correction of the dose is not necessary.

Indications for use

The drug is prescribed:
    in the complex treatment of prostatic hyperplasia or for prevention, in combination with alpha-blockers;
    for monotherapy of prostatic hyperplasia.


The drug is contraindicated for allergies to its components, women and children.
Care should be taken in the presence of liver failure.

Side effects

The frequency of occurrence of adverse reactions and their nature depends on the duration of admission and the availability of ancillary drugs in the treatment of hyperplasia.
Observed were:
    urticaria, itchy skin rashes, swelling, other allergic reactions up to angioedema;
    depression, apathy;
    testicular edema and pain;
    hypertrichosis and loss of hair on the surface of the body;
    erectile dysfunction, decreased libido and libido, problems with ejaculation, painful sensations and swelling of the mammary glands.
The likelihood of an undesirable side reaction decreases with increasing duration of admission (from the second year of taking the drug).
When combined Avodarta with other drugs, the incidence of side effects may differ.

Instructions for Avodart (method and dosage)

The drug is administered alone or in combination with tamsulosin.
Instructions for use of the Avodart for adults
It is recommended to take 1 capsule (0.5 mg) per day. Orally. The capsule can not be cracked or chewed, its contents can damage the mucous membrane of the mouth or pharynx.
Drug is consumed regardless of food. The minimum time for taking the drug is six months.
With kidney and liver diseases, you need to take the remedy with caution. With severe degree of hepatic insufficiency, the drug is contraindicated.


According to clinical studies, there were no abnormalities in patients taking 40 mg of medication per day for a week.
When taking 5 mg of the drug a day for six months, there were also no abnormalities.
The medicine does not have a specific antidote, but if an overdose does occur, it is recommended to perform symptomatic therapy.


Drugs inhibitors of the cytochrome P450 isoenzyme CYP3A4 can increase the concentration of dutasteride in the blood. It has been proved that verapamil and diltiazem lower the clearance of the drug, but amlodipine and other CCBs do not increase the concentration of the drug in the blood. In this regard, correction of the daily dosage is not required.
The drug can be combined with warfarin, colestyramine, acenocoumarol, tamsulosin, fenprocumone, terazosin, digoxin, phenytoin and Diazepam.
There were no undesirable reactions when the drug was combined with ACE inhibitors, BCC, diuretics, PDE-5 inhibitors, lipid-lowering agents, beta-blockers, corticosteroids, nonsteroidal anti-inflammatory drugs, quinolone antibiotics.
Isozymes CYP1A2, CYP2E1, CYP2C9, CYP2D6, CYP2C19, CYP2A6, CYP2C8, CYP2B6 do not participate in the metabolism of the drug.

Terms of sale

To buy Avodart the prescription is not required.

Storage conditions

Keep out of reach of children. Store in a cool place in the original packaging.
Shelf life - 4 years.

special instructions

Capsules can not be opened, allow contact of their contents with the skin or mucous membrane. If liquid has got on the skin, immediately wash it with running water. Especially avoid contact with the drug should women and children.
Despite the fact that there is no direct and direct dependence on the administration of the drug and the development of heart disease, it has been shown during the studies that the combination of dutasteride with alpha-blockers slightly increases the risk of this disease.
Patients with severe impairment of liver function should avoid taking this medication.
Before prescribing the drug and during the treatment with the drug, it is necessary to perform a prostate gland (digital rectal examination, PSA tests). Six months after the start of the drug should be determined a new initial level of PSA and then carefully monitor it. It should be remembered that any (even within the limits of the norm) increase in post-specific antigen level can serve as a signal about the development of prostate cancer.
Within half a year after discontinuation of the drug, the PSA level returns to normal.
It is not proved and there was no direct relationship between the drug intake and the development of breast cancer in men.
During the long 4-year studies of dutasteride, it has been shown that its administration does not increase the likelihood of developing highly differentiated prostate cancer. However, men who take the drug should monitor the level of PSA.
Clinically significant dependence of quality and quantity of spermatozoa in sperm on the duration of the drug was not revealed.

Penester or Avodart - which is better?

Penester has another active substance - finasteride. Unlike the original, it can be combined with other medicines. Also, the analog preparation has fewer side effects. Both drugs are effective enough in the fight against prostatic hyperplasia. Much depends on the individual characteristics of the body.

Reviews about Avodart

Reviews about Avodart in the forums are different. Some write that after annual use of the drug, the prostate gland decreased, but when the reception was stopped, it again increased slightly. Others are unhappy with the high cost of the drug. There are reviews in which men are indignant about the decline in sexual desire and erectile dysfunction in the first months of taking the remedy. In this case, it should be borne in mind that the normal sexual function, as a rule, is established after 3-4 months after the start of the drug. The incidence of adverse reactions is small, but there are cases of acute intolerance to the drug and the appearance of lost hair on the head.

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