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Sildenafil 50mg #4

  • $16.99
  • 3 or more $16.10
  • Availability:In Stock

Sildenafil instructionYou can buy Sildenafil hereCompositionContains 70.24 mg of Sildenafil citrate, equivalent to 50 mg of Sildenafil, or 140.48 mg of Sildenafil citrate, equivalent to 100 mg of Sildenafil. From the auxiliary sub..

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Sildenafil instruction

You can buy Sildenafil here


Contains 70.24 mg of Sildenafil citrate, equivalent to 50 mg of Sildenafil, or 140.48 mg of Sildenafil citrate, equivalent to 100 mg of Sildenafil. From the auxiliary substances: lactose monohydrate, microcrystalline cellulose, povidone, magnesium stearate, titanium dioxide macrogol, indigocarmine.

Form of issue

Tablets coated with a coating in a blister for 1 or 4 tablets.

pharmachologic effect

Means that increase the erection.

Pharmacodynamics and pharmacokinetics


The drug restores the lost reaction to sexual arousal. Normal erection is impossible without the release of nitric oxide in the cavernous body of the penis, which activates the enzyme guanylate cyclase. Activation of this enzyme entails an increase in the level of a specific nucleotide - cyclic guanosine monophosphate (cGMP). This nucleotide is necessary for relaxation of the muscles of the cavernous body, as a result of which the blood flow in the penis increases. Sildenafil is a selective inhibitor of phosphodiesterase 5, under the influence of which cGMP decays. Thus, Sildenafil citrate affects the increase in blood flow in the genital. In 72% of patients, the sexual intercourse was complete. The action of this drug begins in 1 hour and lasts 3-4 hours.


Absorption: quickly absorbed, bioavailability is 41%. Maximum plasma concentrations are observed on average 1 hour after fasting. The intake of alcohol and fatty foods slows down absorption.
Distribution: binds to plasma proteins, evenly penetrates into tissues.
Metabolism: metabolized by liver enzymes. The main metabolites are metabolized further, and their half-life is 4 hours.
Excretion: metabolites are mainly excreted with feces (80%) and urine (13%).

Indications for use

Disturbances of an erection of various genesis (psychogenic, organic or mixed).


    hypersensitivity to the drug;
    deformation of the penis;
    simultaneous treatment with nitrates;
    tendency to bleeding;
    renal failure and cirrhosis;
    severe form of hypo- and hypertension;
    unstable angina;
    stroke or myocardial infarction (the first 6 months);

Side effects

Possible adverse reactions are indicated by frequency of occurrence.
    headache, flushing to the face;
    impaired vision;
    nasal congestion;
    skin rash;
    urinary tract infections;
Other side effects include fainting, sleep disturbance, ringing in the ears, photophobia, hypotension, tachycardia, angina attacks, increased cough, increased sputum, dry mouth, thirst, rectal bleeding, frequent urination, swelling of the genitalia, myalgia, arthritis. In studies, these reactions were noted with the use of Sildenafil 100 mg.

Instructions for use Sildenafil (Method and dosage)

Tablets are taken orally for one hour before sexual intimacy. For adults, a single dose is 50 mg per day. Taking into account the tolerability and effectiveness of the drug, you can reduce the dose to 25 mg or increase to 100 mg, which is the maximum single dose. For the elderly, you do not need to change the standard dosage.

Instructions for the use of Sildenafil for different patient categories

In case of renal dysfunction: in the presence of renal failure of mild to moderate severity, the dose does not change. Severe renal failure requires a dose reduction of up to 25 mg.
If liver function is impaired: with cirrhosis, the drug is started at a dose of 25 mg.
When using other drugs: with the use of CYP3A4 inhibitors, the dose is 25 mg. The exception is ritonavir, a joint reception with which is not recommended.
When patients use alpha-adrenoreceptor blockers, the dose is 25 mg, since there is a risk of developing orthostatic hypotension.
The drug does not provide indications for patients under 18 years of age. Elderly patients do not change the dose.


In case of an overdose, side effects appear more clearly. A dose of 200 mg is not more effective, but the frequency of occurrence of reactions is higher. Taking the drug by volunteers at a dose of 800 mg led to the fact that the incidence of adverse reactions and the degree of their severity increased. In the treatment of symptomatic therapy.


Erythromycin, ketoconazole and cimetidine reduce the excretion of Sildenafil with an increase in its content in the blood. Together with sodium nitroprusside, the antiplatelet effect of the latter increases.
When combined with organic nitrates, their hypotensive effect intensifies, which can lead to death.
Contraindicated simultaneous reception with hypoglycemic drugs and beta-blockers, which can also be a danger to life.

Storage conditions

Store in a dry place. Storage temperature is not higher than 25 ° - 300 ° C.
Shelf life - 2 years.

Sildenafil for Women

For women, the drug is produced under the brands: Ladygra, Womenra, Femalegra. The active component of the tablets is also Sildenafil citrate, equivalent to 50 mg or 100 mg of Sildenafil.
It is used to increase sexual activity and sensitivity during sexual intercourse. Tablets of 50 mg are taken one hour before the planned sexual intercourse. Taking into account the effectiveness of the dose increases (100 mg per reception) or decreases (25 mg). The maximum dose is 100 mg.
Possible adverse reactions when taking the drug: headache, dizziness, nausea, nasal congestion, photophobia, impaired vision.
It must be taken into account that the drug has a negative effect on uterine fibroids. In this connection, the question of its use is decided by the gynecologist.

Sildenafil analogues

Viagra. Analogs have the same composition: in terms of Sildenafil - 25.0 mg, 50.0 mg or 100.0 mg.

Reviews of Sildenafil

Reviews about Sildenafil indicate that the use of the drug is characterized by high reliability. The tolerability of the drug is generally good. It is noted that transient adverse reactions occur when taking a dose of 100 mg. The majority of patients taking the drug were slightly expressed: redness of the face, headache, dyspepsia, nasal congestion, changes in color perception. Very rarely, they were the reason for refusing the drug.
It is noted that the drug is effective in erectile dysfunction, which arose against the background of spine and spinal cord injuries, after prostatectomy and diabetes mellitus.
It is noted from the shortcomings of the drug that it can not be taken with certain medicinal preparations, for example, organic nitrates. This point is important, because erectile dysfunction is often combined in men with heart disease.

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