Agalates tabs 0.5mg #8

Agalates pills instruction

You can buy Agalates online

Composition

In 1 tablet of cabergoline 0.5 mg.
Lactose, magnesium stearate, L-leucine as auxiliary substances.

Form of issue

Pills.

pharmachologic effect

Stimulation of dopamine receptors.

Pharmacokinetics and pharmacodynamics

Pharmacodynamics

The active substance is a synthetic ergot alkaloid, a dopamine receptor agonist, which inhibits the secretion of prolactin by stimulating the dopaminergic receptors of the hypothalamus. The effect of the drug depends on the dose. Reduction of prolactin in the blood is observed after 3 hours and lasts 2-3 weeks, so it is enough to take one pill to stop lactation.
In the treatment of hyperprolactinemia in women and men, prolactin levels normalize after 3-4 weeks of treatment.
The drug has a highly selective effect, is highly safe, well tolerated by patients.
Another effect is a decrease in blood pressure, the degree of reduction of which also depends on the dose. The hypotensive effect occurs after 6 hours.

Pharmacokinetics

Quickly absorbed from the gastrointestinal tract. In the blood it is determined after 1-4 hours. 42% is associated with blood proteins. All metabolites of cabergoline inhibit the production of prolactin, but to a lesser extent. T 1/2 about 80-114 h in patients with hyperprolactinemia. In urine, 18% of the dose received, and vkale 72%.

Indications for use

    prolactin secreting benign pituitary adenomas;
    suppression of postpartum or steady lactation;
    hyperprolactinemia;
    amenorrhea, galactorrhea, anovulation, oligomenorrhea associated with hyperprolactinemia;
    unspecified oligomenorea;
    idiopathic hyperprolactinemia.

Contraindications

Agalates is contraindicated in:
    postpartum arterial hypertension;
    hypersensitivity to the drug;
    violations of liver function;
    psychoses in the anamnesis;
    pre-eclampsia and eclampsia;
    age under 16 years;
    application with antibiotics - macrolides;
    lactose intolerance;
    defeat of the valves of the heart, which arose on the background of treatment with cabergoline.

Side effects

Agalates with prolonged use can cause:
    hallucinations, headache, sleep disorders, dizziness, increased libido, drowsiness, depression;
    skin rash;
    hypotension, palpitation, angina, pericarditis with effusion, peripheral edema, damage to the heart valves;
    nausea, abdominal pain and epigastric region, dyspepsia, vomiting, constipation;
    abnormal liver function;
    shortness of breath and pleural effusion;
    asthenia, weakness;
    impaired vision.

Instructions for Agalates (Method and Dosage)

Cessation of steady lactation - 0, 25 mg 2 times, 2 days. Termination of lactation after childbirth - 1 mg immediately after the birth of the child.
Treatment of hyperprolactinemia - 0.5 mg per week (in 1 or 2 admission). Then the dosage is increased, for a month it can be increased by 0.5 mg. At a dose above 1 mg per week, it should be divided into 2 -3 doses. The maximum dose per week is 4.5 mg, the maintenance dose is 1 mg.
The experience of using the drug in patients older than 65 years has not been studied.

Overdose

Cases of overdose are not registered. However, there is a possibility of nausea, vomiting, psychosis or hallucinations, a decrease in blood pressure. With severe symptoms, sometimes the appointment of Bromopride, Domperidon.

Interaction

Agalates should not be used with dopamine receptor antagonists (metoclopramide, phenothiazines, thioxanthenes).
You can not prescribe it in combination with macrolides - there is a possibility of increasing the concentration of cabergoline in the blood. It is not recommended long-term joint use with other ergot alkaloids.
With caution appoint together with antihypertensive drugs. No interaction was found with levodopa.

Terms of sale

To buy Agalates online you don't need a prescription.

Storage conditions

Storage temperature not higher than 30 ° C.
Shelf life - 3 years.

Reviews about Agalates

Analyzing reviews on Agalates, you can make a conclusion about the effectiveness of the drug. This is written by women with hyperprolactinemia - one of the causes of infertility. Here are some testimonials:
"Saw Agalates 8 weeks, tolerated it normally, passed the tests - prolactin norm"
"... drank Agalates 4 months, now 7 weeks pregnant"
"... there are no side effects, I carry it perfectly!"
"Agalates was prescribed to me, it is easier to bear, since bromocriptine could not drink at all because of severe headaches and dizziness"
"I drank this drug for 3 months in 2007 and became pregnant ..."
There are also reviews of the cessation of lactation with this drug, and they indicate that many women prefer this particular drug: they are satisfied with the average cost, short course of admission. Indeed, one-time reception is very convenient.
Some note nausea, dizziness swelling even with a single admission. Thus, the tolerance of the drug is different for all.