Dostinex 0.5mg #8

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Instruction for Dostinex

The drug Dostinex belongs to the group of inhibitors of the production of the hormone prolactin.

Form release and composition of the medicine

The drug Dostinex is available in the form of tablets for oral administration. Tablets are white, oblong with engravings on both sides. The drug is sold in bottles of brown glass of 2 or 8 pieces in a cardboard box with detailed instructions. One Dostinex tablet contains 500 μg of the main active ingredient, cabergoline. Auxiliary substances of the drug are anhydrous lactose and leucine.

Pharmacological properties of the drug

The drug Dostinex is an agonist of dopamine receptors. Under the influence of the drug decreases the production of the hormone prolactin and a decrease in its concentration in the blood plasma.
After taking the drug inside after 3 hours, a decrease in the level of prolactin in the blood. The therapeutic effect lasts from 1 to 4 weeks. The effect of the drug is dose-dependent.
Active active substance of the drug affects only those areas of the pituitary gland that are responsible for the production of prolactin, while not affecting other departments and not affecting the level of other hormones. Under the influence of the drug, perhaps a slight decrease in blood pressure in patients, the hypotensive effect persists for 6 hours after taking the tablet inside.

Indications

The drug is administered to patients with the following goal:
    Termination of the natural process of milk production after childbirth in a woman (with contraindications to feeding or for a number of other reasons);
    Prevention of lactation after dysfunctional delivery;
    Treatment of pathological conditions in a woman due to increased production of the hormone prolactin by the pituitary gland - amenorrhea, oligomenorrhoea, anovulation, galactorrhea, not associated with breastfeeding;
    Adenoma of the pituitary gland, which affects the site responsible for the production of prolactin, hyperprolactinaemia.

Contraindications

The drug Dostinex can be used only as directed by a doctor. Before starting therapy, the patient should carefully read the attached instructions, since the tablets have a number of the following contraindications:
    Age to 16 years;
    Individual intolerance to the components of the drug.
With special care, the drug is prescribed to patients with the following conditions:
    Arterial hypertension;
    Pregnancy;
    Raynaud's disease;
    Severe dysfunction of the heart;
    Liver failure;
    Peptic ulcer, exacerbation of chronic diseases of the gastrointestinal tract;
    Mental illness in the anamnesis;
    Disturbance of respiratory function.
The drug should be used with caution at the same time as medications that lower blood pressure, as this drug interaction may lead to the development of orthostatic hypotension.

Dosing and Administration

The drug is taken orally while eating, without chewing, with plenty of water. Depending on the indications, the daily dose is set by the doctor individually.
To prevent milk production after childbirth, Dostinex is prescribed 2 tablets once a day for delivery. In order to suppress the established lactation, the patient is prescribed 1/2 tablet of the drug in the morning and in the evening for 2 days.
For the treatment of pathological conditions due to hyperprolactinemia, Dostinex is prescribed 1 tablet 1 time per week or ½ tablets 2 times a week. The drug is taken for 4 weeks.
In patients at risk, side effects may occur, so the drug is prescribed in a reduced dose, which is set by the doctor individually. With good tolerability and no side effects, the dose of the drug is gradually increased to the recommended dose in the instructions.

Use of the drug during pregnancy and lactation

Data on the safety of the effect of the drug on development of the fetus are not available in medicine, so this drug can be used to treat future mothers only if there are serious indications when the expected benefit for the mother exceeds the potential risk for the unborn child.
If the woman took the drug before pregnancy and found out that the conception has come, you should definitely inform the doctor about it and stop the therapy as soon as possible. After completing the course of therapy, Dostinex woman is not recommended to plan pregnancy in the next month. According to medical statistics, women who became pregnant immediately after completing the course of therapy with the drug are more prone to fetal development abnormalities and miscarriages at an early stage.
Since the drug Dostinex suppresses the established lactation, this medication is not prescribed for those women who want to continue breastfeeding.

Side effects

On the background of therapy with this drug in patients, the following side effects may develop:
    Increased heart rate, lower blood pressure;
    Nausea, stomach pain, vomiting, constipation, development of gastritis or exacerbation of gastric ulcer, dyspepsia;
    Headaches, fatigue, lethargy, weakness, development of depression, paresthesia, fainting;
    Bleeding from the nose, sensations of heat in the head and face, hyperemia of the face;
    Tremor of limbs;
    Reduction of hemoglobin level in the blood;
    Disturbance of respiratory function, edema;
    Inhibition of liver function.

Overdose

In case of an overdose, the patient develops the following clinical symptoms:
    Decrease in arterial pressure, collapse, development of acute vascular insufficiency;
    Nausea, profuse vomiting, the development of liver failure, an increase in the boundaries of the liver and an increase in liver transaminase activity;
    Confusion, the development of hallucinations and psychoses.
When there are signs of an overdose, treatment with the drug is immediately canceled, the patient is washed with the stomach, enterosorbents are given inside, symptomatic treatment is performed if necessary.
The doctor prescribes dopamine antagonists to the patient.

Interaction of the drug with other drugs

Since Dostinex acts directly on the dopamine receptors, the drug is not prescribed concomitantly with dopamine antagonist drugs, for example, metoclopramide, thioxanthene, phenothiazine, and others. This drug interaction weakens the therapeutic effect of the drug Dostinex.

special instructions

Before the beginning of therapy with the drug, a complete examination is made to patients to exclude abnormalities in the function of the pituitary gland. Against the background of treatment with the drug once a month, it is necessary to take blood tests to determine the level of hormones, in particular, the concentration of prolactin in the serum. Normalization of prolactin levels in the blood is observed after 2-3 weeks from the beginning of the course of therapy.
The drug restores normal ovulation in patients of reproductive age, so if a woman does not plan pregnancy, then barrier means of contraception should be used.
Patients with impaired liver function, the dose of Dostinex is selected by the doctor individually. Such patients should be constantly under the supervision of a doctor. In case of side effects or violations of the liver, therapy is stopped with the drug.
The drug Dostinex is not prescribed to persons under 16 years of age, since there is no data on the safety of the drug on the body of a teenager in medicine.
In the period of drug therapy, you should avoid driving the car and controlling mechanisms that require increased concentration of the patient's attention.

Storage conditions

Store the drug at room temperature for a maximum of 24 months from the date of manufacture, in a dark place inaccessible to children.