Krinon gel 90mg/dose #15

Krinon buy online

Instruction for Krinon

Composition

In 1 progesterone applicator, 90 mg (1 dose).
Glycerol, paraffin liquid, glycerides of palm oil, sorbic acid, water, polycarbophil, carbomer, sodium hydroxide, - as auxiliary substances.

Form of issue

Vaginal gel 1,125 g in polypropylene applicators.

pharmachologic effect

Progestogen, hormonal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Krinon contains synthetic progesterone identical to natural progesterone - the hormone of the yellow body. Under the influence of the hormone, the uterine mucosa passes into the secretory phase. Progesterone inhibits the formation of gonadotropic hormones, reduces the contractility of the musculature of the uterus and tubes. With this method of administration, it binds to the mucous membrane of the vagina, enters the uterine cavity and is gradually released within 3 days. As a result, higher concentrations are provided in the endometrium when compared with intramuscular administration of progesterone.

Pharmacokinetics

When using the Tmax gel in the blood, it is determined after 6 hours. T1 / 2 - 34-48 hours. Progesterone is metabolized in the liver, but the application of Krinon as a vaginal gel reduces the effect of passing through the liver and allows reaching a high concentration in the endometrium. The main metabolite of progesterone is excreted by the kidneys.

Indications for use

    secondary amenorrhea, uterine bleeding associated with progesterone deficiency;
    maintenance of the luteal phase in IVF;
    climacteric state (replacement therapy in combination with estrogens).

Contraindications of Krinon

    hypersensitivity;
    porphyria;
    vaginal bleeding;
    tumors of the genital organs;
    thrombosis or thrombophlebitis;
    ONMK;
    incomplete abortion;
    breast-feeding.
It is used in the first trimester of pregnancy, in later periods it is not recommended to use it. With caution is prescribed for arterial hypertension, renal and cardiovascular insufficiency, asthma, migraine, diabetes mellitus, epilepsy, depression.

Side effects

    skin rash;
    drowsiness;
    headache;
    intermenstrual bleeding;
    pain in the mammary glands;
    stomach ache;
    irritation of the vaginal mucosa.

Krinon, instructions for use (Method and dosage)

The drug is administered intravaginally.
To maintain the luteal phase after IVF / ICSI. From the day the embryo is transferred daily, 1 applicator. With confirmation of pregnancy, support is continued until 12 weeks.
With secondary amenorrhea and uterine bleeding associated with a deficiency of progesterone. A dose of gel is administered every other day from the 15th to the 25th day of the cycle.
As a replacement therapy in postmenopause - 1 applicator 2 times a week.
In case of missing the next dose of the gel, it is necessary to carry out the procedure immediately, but do not increase the recommended dosage. Do not use the drug at the same time as other vaginal preparations. For hygienic reasons, the drug is packaged in a disposable applicator. It can be administered in a sitting or lying position with bent knees. A small amount of gel remains in the applicator, but the required dose is completely introduced.

Overdose

There were no cases of drug overdose.

Interaction

There are no data on the interaction. It is not recommended to use it with other intravaginal agents.

Storage conditions

Storage temperature up to 25 ° C.
Shelf life - 3 years.

Analogues

Progestogel, Utrogestan.

Reviews about Krinon

Progesterone is necessary for the onset of pregnancy - it prepares the endometrium for implantation of the embryo. All patients note the convenience and ease of use of the gel, and prefer this method of administration compared with intramuscular injection. It is also noted that the bioadhesive gel does not flow (as compared with progesterone candles), so there is no loss of the active substance. "I became pregnant on Krajnon, very convenient to use."
Most often there are reviews about Krinon, used with assisted reproductive technologies to support up to 8-12 weeks. At 14 weeks, the placenta is already formed, and there is no point in using progesterone drugs. The blood test for hCG is performed from day 12 after embryo transfer.
When prescribing progesterone medications, the temperature can rise to 37.5 - this is normal. Some women after Krajnona have a discharge that is pinkish, beige or brown in color. White discharge can be considered as a variant of the norm, and when staining the secretions it is necessary to increase the hormonal support and you need to see a doctor. With long-term use, the base of the gel accumulates. It is advisable to mechanically clean the vagina once every 2 days with a sterile gauze pad before the next administration of the drug. Among the side effects in women, headache, drowsiness and constipation were noted.