Longidaza supp 3000ME #10

Instruction for Longidaza

You can buy Longidaza suppositories on this page online

Composition

The preparation in the form of suppositories for rectal or vaginal use has a hyaluronidase conjugate with a high molecular weight water-soluble carrier (polyoxidonium), as well as additional ingredients (cocoa butter).
In one bottle with the powder intended for the preparation of the Longidaza solution, a conjugate of hyaluronidase with a copolymer is contained, as well as auxiliary ingredients (mannitol).

Form of issue

The product is available as a lyophilizate for the preparation of a solution for injection. It is a white or yellowish-white porous hygroscopic mass that is contained in ampoules or in vials of dark glass at 15 mg (dosage 1500 IU) or 20 mg (3000 IU dosage).
In the outline cell box of PVC contains 5 bottles or ampoules. One cardboard pack holds 5 ampoules.
Longidaza suppositories are contained in a 5-unit cell outline, in the carton pack there are 1 or 2 packs of the product.

pharmachologic effect

Longidaza is a macromolecular complex of the proteolytic enzyme hyaluronidase with a high molecular weight carrier. The drug has high hyaluronidase activity. On the organism, Longidasa has anti-edematous, immunomodulating, antioxidant, anti-inflammatory, chelating effects. When applying Longidaza, an antifibrotic effect is noted.
When using the drug, trophic and permeability of the tissues are markedly increased, hematomas dissolve, edemas decrease, the level of elasticity of scars increases.
In view of the glycosylation of glycosaminoglycans, adhesions and contractures completely decrease or completely disappear. Increased mobility of the joints is noted.
The highest efficiency is observed when the drug is used in the initial stages of diseases and pathological processes.
Antioxidant effect is achieved due to the binding of the active substance of the preparation with iron ions, activating free radical reactions. There is also a pronounced activation of collagen synthesis.
The drug improves the humoral immunity, weakens the severity of acute inflammatory processes.
Given the fact that the drug does not provoke a worsening of the patient's condition after the operation, it is used to prevent the appearance of rough scars and the development of adhesive process.
Under the influence of Longidaza bioavailability of a number of other drugs increases, the action of local anesthetics is activated.
The drug is low-toxic, so it does not adversely affect the immune system and reproductive functions. Does not have a mutagenic, carcinogenic, teratogenic effect on the body.

Pharmacodynamics and pharmacokinetics

When administered parenterally, the active substance quickly enters the systemic circulation, where its maximum concentration is reached after 20-25 minutes. The substance is quickly distributed in the body, its bioavailability is not less than 90%. The active substance is able to penetrate all tissues and organs.
Hyaluronidase in the body undergoes hydrolysis, and the carrier disintegrates into low-molecular compounds that are excreted in two phases through the kidneys. In the first day, kidneys are excreted about 45-50%, intestines - about 3%. After that, the elimination process slows down. Completely the drug is excreted from the body after 4-5 days.
When applying Longidaza rectally, its active substance is rapidly absorbed into the bloodstream. Its maximum concentration in plasma is observed after about 1 hour. When used rectally or vaginally bioavailability is 70%. The half-life can be from 42 to 84 hours.

Indications for use

Longidaza is assigned to adult patients as part of complex treatment, as well as to prevent diseases in which connective tissue hyperplasia is noted.
    Gynecology: therapy and prevention of adhesions in the pelvic organs with inflammatory diseases (endometritis, infertility, intrauterine synechia).
    Urology: interstitial cystitis, chronic prostatitis.
    Cosmetology, dermatovenereology: keloid, forming, hypertrophic scars, limited scleroderma.
    Surgery: adhesions after surgery, hypertrophic scars, wounds that do not heal over a long period.
    Pulmonology, phthisiology: pneumosclerosis, tuberculosis, fibrosing alveolitis.
    Orthopedics: arthrosis, joint contracture, ankylosing spondylitis, hematomas.
In addition, Longidaza is used to increase bioavailability when using certain antibacterial agents and also to enhance the effect of local anesthetics.
Which is better, injections or candles - the doctor determines in each case individually. Before starting therapy, the patient must necessarily inform the doctor about the medicines he is taking.

Contraindications

Do not apply Longidaza in the following diseases and conditions:
    high sensitivity to agents based on hyaluronidase;
    hemoptysis, pulmonary hemorrhage;
    acute infectious diseases;
    a recent hemorrhage in the Vitreous humor;
    malignant tumors;
    kidney failure;
    children and adolescence up to 18 years.

Side effects

Rarely with the use of the drug, patients noted the manifestation of local or systemic allergic reactions.
Also, as side effects, pain was noted in the place where the solution is introduced, as well as redness, itching. All local manifestations disappear after 2-3 days.

Instructions for use Longidaza (Method and dosage)

If the patient is prescribed long-dose 3000 injections, the instruction indicates that the solution must be injected subcutaneously under the scar tissue modified or near the affected area. Also, the drug can be administered intramuscularly. Depending on the disease, a course of treatment is prescribed, which includes 5-25 injections. With the injections, the interval can be from 3 to 10 days. If there is such a need, a second treatment is prescribed after 2-3 months.
In some diseases, the doctor may prescribe a long-term maintenance treatment with Longidazoy, in which the injections are given once every 10-14 days.
Before use, the contents of the ampoule or vial are dissolved in 1-2 ml of the procaine solution (0.25 or 0.5%). If the patient is intolerant to procaine, the agent dissolves in a similar volume of water for injection or a 0.9% sodium chloride solution.
If the drug is prescribed to increase the bioavailability of other drugs, the contents of the vial or ampoule of Longidaza 3000 should be dissolved in 2 ml of sodium chloride solution 0.9%, and the contents of the bottle or ampoule of Longidaza 1500 - in 1 ml of the solution. Enter the solution in this case in the same way and at the same place as the main drug, but 10-15 minutes before the introduction of the main drug.
In the ampoule, the solvent is introduced slowly, after which it is kept for 2-3 minutes. Stir it carefully, not sharply shaking. The solution can not be stored, it is not administered intravenously.
It is not recommended to take alcohol during treatment with the drug.

Instructions for the use of Longidaza suppositories

Rectally, they need to be administered after the cleaning of the intestine. Vaginal administration is performed before bedtime in the supine position.
In urology 1, the suppository is administered 1 time at 48 hours rectally, after 10 doses the interval between administrations continues for 2-3 days. One course of treatment includes 20 suppositories.
    In gynecology: 1 suppository once every 3 days is administered rectally or vaginally. One course of treatment includes 10 suppositories.
    In dermatovenerology: 1 suppository once every 2-3 days is administered rectally. One course of treatment includes 10-15 suppositories.
    In surgery: 1 suppository once every 2-4 days is administered rectally. One course of treatment includes 10 suppositories.
    In pulmonology and phthisiology: 1 suppository once every 3-5 days is injected rectally. One course of treatment includes 10-20 suppositories.
The repeated course of treatment is appointed no earlier than 3 months after the first course of treatment.
People suffering from chronic kidney failure and those who have recently had a bleeding experience the administration of no more than 1 suppository of Longidaza in 7 days.

Overdose

Overdosing with the use of a solution of Longidaza can trigger a feeling of chills, dizziness, fever, lower blood pressure. In this case, it is necessary to stop the administration of the remedy and perform symptomatic treatment.
Overdosage with the application of suppositories Longidaza was not noted.

Interaction

Longidaza in combination with other drugs increases the effectiveness of the effects of diuretics, antimicrobials, local anesthetics.
If Longidaza is used simultaneously with large doses of estrogens, salicylates, antihistamines, cortisone, adrenocorticotropic hormone, its effectiveness is reduced.
Longidaza is not prescribed simultaneously with phenytoin, furosemide, benzodiazepines.
It is possible to jointly take Longidaza and antiviral, antifungal agents, as well as antibiotics, bronchodilators.

Storage conditions

Keep the drug in a dark and dry place, the temperature should not exceed 15 ° C. Longidaza should be protected from children's access.

Shelf life

You can store the product for 2 years.

special instructions

If it is necessary to stop therapy, Longidaza can be canceled without a gradual dose reduction.
If you involuntarily miss a regular dose of the drug, you can enter it immediately, as soon as a person remembers it. Further treatment continues according to the usual scheme.
When taking the drug, there is no effect on the ability to drive traffic and work with precise mechanisms.
Analogues of Longidaza
Given the relatively high cost of the drug, many patients are trying to find cheaper candle analogues and Longidaz injection products in pharmacies. To date, there are no analogues of suppositories on the active substance. Specialists can offer some drugs that have a similar effect. This is Lidase

Children

Not applicable until the patient's 18th birthday.

With antibiotics

Longidaza is compatible with antibiotics.

With alcohol

In the official annotation there is no information on whether alcohol and Longidas are combined. However, doctors do not recommend combining alcohol and drug treatment. This combination can provoke an unexpected negative reaction of the body.

In pregnancy and lactation

The preparation of Longidaza during pregnancy and with natural feeding of the baby is not recommended. If this treatment is necessary, it is necessary to interrupt the lactation process.

Reviews about Longidaza

On forums and specialized sites, there are mostly positive responses about Longidaz 3000 injections, as well as reviews of Longidaz candles.
Especially often women note the positive effect of the drug in gynecology. In particular, it helps to get rid of adhesions, is effective in ovarian cysts, in the treatment of endometriosis, etc. There are reviews that, after treatment of gynecological diseases, Longidasa finally came the long-awaited pregnancy.
It is important to choose the right treatment regimen and stick to it exactly. In reviews, it is sometimes mentioned that short-term allergic reactions occur as side effects.