Tergynan vaginal tablets #6

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Instruction for Tergynan vaginal tabs

Composition

In addition to the active components, the Terginan vaginal tablet contains: wheat starch (Amylum tritici), silicon dioxide colloid (Silicii dioxydum colloidale), sodium starch (type A, Natrii amylum), magnesium stearate, lactose.

Form of issue

Drug form of the drug Tergynan - vaginal suppositories.

pharmachologic effect

Tergynan is a drug from the group of combined antimicrobial, antifungal and antiseptic medicines used in gynecological practice.
The physiological effect and pharmacological properties of the drug are due to the activity of the active components entering into its composition. Against the background of treatment Tergynan marked:
    trihomonatsidny;
    antibacterial;
    antifungal;
    anti-inflammatory effects.

Pharmacodynamics and pharmacokinetics

The action of terinidazole, which is part of Tergynan, is aimed at the death of trichomonads. In addition, it provokes the death of anaerobic microorganisms and, in particular, is active against facultative anaerobes of the Gardnerella genus.
Neomycin is an antibiotic from the aminoglycoside group. The mechanism of its action is associated with the ability to irreversibly destroy at the ribosomal level the synthesis of protein in the cells of pathogenic microorganisms.
Suppressing the synthesis of protein, neomycin causes violations in the transcription of the genetic code and provokes the death of microbial cells. It has been experimentally proved that, as a rule, aerobic bacteria are sensitive to it: corynebacteria (C. amycolatum), listeria (Listeria), and methicillin-sensitive Staphylococcus aureus (MSSA).
In addition, it was found that the sensitivity to neomycin is also possessed by Gram-negative bacteria, including the Pseudomonas aeruginosa (P. aeruginosa), which is usually resistant to the action of this antibiotic.
Nystatin is an antimycotic agent from the group of polyene antibiotics. Linking to the ergosterol contained in the envelopes of fungal cells, it causes their damage and thereby provokes the death of fungi.
Nystatin has an effect only on eukaryotes. Sensitive to it are fungi belonging to the genus Candida, including including strains of Candida albicans and Candida glabrata.
Prednisolone is a glucocorticosteroid drug. With topical application, its therapeutic activity is determined by anti-inflammatory, anti-allergic and anti-exsudative action. The latter is due to the vasoconstrictor effect of prednisolone.
The excipients included in the vaginal tablets ensure the integrity of the vaginal epithelial tissue in various infectious and inflammatory diseases, and also maintain pH-balance values ​​within the physiological norm.
Pharmacokinetic characteristics of Tergynan have not been studied, which is associated with low systemic absorption of this drug.
Indications for use: what Terginan treats and when it is expedient to prescribe it
Indications for the use of vaginal tablets are infectious diseases of female external genital organs, accompanied by inflammatory processes, caused by ingestion and active vital activity in the vagina of pathogenic microorganisms sensitive to Tergynan.

So, vaginal pills, what are they from? The medicine is prescribed for women who have been diagnosed with:

    vaginitis, provoked by a banal pyogenic microflora;
    chronic recurrent colpitis (nonspecific vaginitis);
    vaginal dysbiosis;
    Trichomonas vaginitis;
    vaginitis caused by the activity of fungi Candida albicans;
    vaginitis of mixed origin origin.
Tergynan is also often prescribed as a preventive measure to prevent the development of vaginitis in women who are undergoing small and large pelvic surgery.
In particular, the drug is used before birth, surgical abortion, diathermocoagulation (it is advisable to administer the tablets both before and after the procedure), contrast radiographic examination of the uterus cavity and the fallopian tube passableness (metrosalpingography), before and after intrauterine contraceptive ect.
Also, Tergynan is used as a means of preventing complications of antibacterial therapy.

The use of Terginan suppositories with ureaplasmosis

Despite the fact that the active growth of ureaplasmosis is most often associated with malfunctions in the immune system, treatment with the use of immunomodulatory medications does not always achieve the desired result.
In this situation, resort to the appointment of special antibacterial agents or antibiotics. Very often with ureaplasma, doctors recommend Tergynan, which acts on a wide range of pathogenic microorganisms and provides a pronounced anti-inflammatory effect.
A valuable property of the drug is that, while provoking the death of microbes and fungi, it does not violate the natural microflora of the vagina.

Terjinan with thrush

Tergynan is recommended for treatment of women whose thrush is suspected of having secondary inflammation and / or infection with a secondary microflora.
In addition, Tergynan is used in cases where the symptoms are so pronounced that they should be quenched as soon as possible.
In some cases, the drug is indicated as a substitute for complex therapy, if the previous treatment with other antifungal agents was ineffective.
Reviews of candles for thrush, left by patients and practicing gynecologists, suggest that Tergynan successfully cures the fungal infection without provoking unwanted side effects.

Contraindications

Contraindications to the appointment of Tergynan are allergic reactions and individual intolerance of any of its constituent components. If treatment with the drug is accompanied by an allergy, the doctor should replace it with a more suitable one.
Vaginal tablets are not intended for treatment of patients younger than 16 years of age.

Side effects

Tergynan rarely provokes side effects. Because the suppositories are used topically, the constituent components are absorbed into the systemic blood stream in very low concentrations.
Therefore, in most of the reported cases, they provoked exclusively local reactions, which were expressed as symptoms of allergy, burning sensation, tingling, itching, soreness and irritation at the injection site.
Systemic effects on the background of drug treatment occur in isolated cases. A possible response to the use of glucocorticosteroids (and, in particular, prednisolone) is the slowing down of healing processes of wounds and cracks, and in some patients atrophic processes in the mucosa may occur.

Suppositories Tergynan: instructions for use

Instructions for use Tergynan recommends the introduction of vaginal pills deep into the vagina one at a time every day for ten days.
Before you enter the tablet into the vagina, it should be lowered into the water for about 30 seconds (or hold it in a wet hand for about two minutes). If the tablet is administered by day, and not in the evening, after its administration, lie down for at least ten minutes.
The best time for the procedure is evening time. This is due to the fact that in the morning after the introduction of Tergynan, yellowish discharge may appear, which is the norm during the course of treatment with the drug.
If the goal of the treatment is to normalize the imbalance of the microflora in the vagina and to remove the symptoms of inflammation, the duration of treatment, depending on the clinical picture and the appointment of the doctor, is six to ten days.
If the cause of the drug is thrush, the course of therapy is increased to 20 days. Three days after its end, it is recommended to undergo a second examination and take tests that either confirm full recovery or indicate the need for a repeat course.
At pregnancy the dose and duration of treatment are determined by the attending physician depending on the clinical situation.

Is it possible to use suppositories with monthly?

Very often in patients who are treated with Tergynan, the question arises whether it is possible to use these pills during menstruation. In the instructions to the drug manufacturer indicates that the monthly does not indicate a cessation of treatment.

Overdose

To date, there are no reports of an overdose by Tergynan. Since the components of the drug are not practically absorbed into the blood, an overdose is considered impossible.
Potentially, an overdose of drugs may increase the severity of manifestations of adverse reactions. This requires the withdrawal of the drug and the appointment of symptomatic treatment.

Interaction

Drug and other forms of Tergynan's interaction have not been identified.

Storage conditions

Packaging with vaginal tablets is recommended to store at room temperature (not more than 25 ° C).
Shelf life - 36 months.

special instructions

The results of studies of the effectiveness of the constituents of the drug Tergynan demonstrated that the concentrations of the active components in this preparation for topical therapy (but not for ingestion per os) are above the toxic concentrations that determine the development of immunity to the antibacterial component.
Under similar conditions it is assumed that the activity of strains of the causative agent of the infection, theoretically resistant to the active substance, will be suppressed by its high concentrations.
In addition, it is highly probable that high concentrations of all active components of Terginan can have a synergistic effect on the pathogenic microflora, which is much broader in the spectrum of its action than in each individual active component.
It should be remembered that preparations with nystatin, intended for intravaginal use, can damage contraceptives from latex.
Given that the active components of Terginan can potentially be slightly absorbed into the systemic circulation, it should be remembered that when using systemic glucocorticosteroids, patients with osteoporosis, arterial hypertension and heart failure should be monitored by specialists of the appropriate profile.
Specialists are also required to observe a peptic ulcer, tuberculosis, glaucoma, hypothyroidism, serious emotional disorders, myopathy provoked by glucocorticosteroids, liver failure, epilepsy, diabetes mellitus, and recent myocardial infarction.

Which is better: Tergynan or Polygynax?

The action exerted by the preparation Polizinaks is identical to the action that Tergynan has. However, studies aimed at a comparative evaluation of the activity of the components of these two drugs in in vitro models showed that Terzinan, unlike Polizhinax, does not have effects on MRSA (methicillin-resistant staphylococcus aureus), streptococci and enterococci. At the same time he showed great activity with regard to gardnerella vaginalis (G. vaginalis).
Also often women ask themselves questions: "Which is better: the Geksicon or Terginan? Tergynan or Penotran? ". Both these preparations have a similar effect to Tergynan, but differ from the latter in composition.
That is, the active substances of each of these drugs can exhibit different activities with respect to the same microorganisms. Therefore, it is up to the attending physician to decide which of the drugs is better and which is less effective.

Terjinan is an effective tool for women. And what for men?

Gynecologists constantly remind that all infectious and inflammatory diseases, for treatment of which Tergynan is shown, must be eliminated both by the woman and by the man. For this, both partners must necessarily undergo treatment with antibacterial drugs.
Neglect of this point is fraught with the fact that all unpleasant symptoms, manifested in this or that disease, will return back. For the entire period of treatment, it is also recommended to refrain from sex, but some doctors sometimes still allow partners to lead a regular sex life.
The main conditions - the mandatory use of a condom and the complete absence of any side effects from the reproductive system (for both women and men).
For example, in some women during sexual intercourse (or some time after it) there may be a burning sensation, the complaints of men are more often associated with unpleasant sensations and some discomfort.
In any of these cases, the best solution is to give up sexual intercourse until the treatment is completed. It is important to remember that sexual contact must take place only before the next evening vaginal tablet is introduced (not after!).

Tergynan and alcohol

To drink alcohol during the treatment with vaginal tablets Tergynan is not recommended.
Tergynan during pregnancy and lactation: from which Terginan suppositories are prescribed for pregnant and lactating women

Instruction on Tergynan during pregnancy permits the use of the drug during this period of a woman's life, but only under the supervision of the doctor leading the pregnancy.

Tablets are contraindicated in 1 trimester, during 2 and 3 trimester during pregnancy, the drug is usually prescribed for inflammation of the vagina (vaginitis), which is caused not by one pathogen, but several (that is, bacteria and fungi). Such a disease is called a combination, and for its treatment are suitable combination medicines, which include both an antibiotic and an antimycotic agent.
The low degree of absorption of Tergynan into the systemic bloodstream excludes the possibility of overdose and the probability of transferring the components of the drug through the bloodstream to the developing fetus.
Thus, Terginan suppositories during pregnancy do not have a negative effect on the body of an unborn child. In addition, the drug is allowed to be taken regardless of the administration of oral medications, since its active components do not interact with the components of other drugs.
It is also permitted to use Tergynan in lactation. The main condition for prescribing is a correctly diagnosed diagnosis confirming the need for treatment. The drug is prescribed in the event that more gentle means and methods did not help to eliminate itching and burning.
However, like any other drug, Terginan pregnant and lactating women should not be used without emergency and without prior consultation with a doctor.

Reviews of Tergynan

In their reviews of Terginan candles, almost all women, as the main virtues of this drug, note that the latter is very simple to use, available (Tergynan tablets are relatively inexpensive medicines), in most cases it is well tolerated and very rarely provokes complications and undesirable side reactions.
If we talk about the effectiveness of the drug with thrush, then the reviews of Tergynan on the forums allow us to conclude that this drug has proved to be an effective and safe tool that allows to quickly cure a chronic thrush that activates with any decrease in immunity.
Reviews of Tergynan during pregnancy and breastfeeding suggest that very often this drug is an effective tool (and even in cases where other drugs did not help to solve the problem).
Negative reviews are mainly associated with hypersensitivity reactions to the drug components.
Some women also write that they started bleeding after one or more of Tergynan tablets were injected. Doctors and gynecologists also assure that such a phenomenon has nothing to do with the use of the drug and to determine the cause of its origin it is necessary to undergo an additional examination.