Aminocaproic acid solution 5% 100ml

Instruction for Aminocaproic acid

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Composition

    1 ml of a 5% solution for drug infusion Aminocaproic acid contains 50 mg of active substance called ε (epsilon) -aminocaproic acid. Additional substances: water, sodium chloride.
    1 gram of drug powder Aminocaproic acid contains 1 gram of active substance called ε (epsilon) -aminocaproic acid.

Form of issue

Transparent liquid without color:
    100 ml of liquid in the bottle; 1, 10, 15, 24, 28, 30, 35, 48 or 36 bottles in a cardboard box.
    200 ml of liquid in the bottle; 1 or 28 bottles in a cardboard box.
    250 ml, 100 ml, 500 ml or 1000 ml of liquid in a polymeric container; one container in a polymer bag.
    100 ml of liquid in a polymer container; 50 or 75 containers in a polymer bag.
    250 ml of liquid in a polymer container; 24 or 36 containers in a polymer bag.
    500 ml of liquid in a polymer container; 12 or 18 containers in a polymer bag.
    1000 ml of liquid in a polymer container; 6 or 9 containers in a polymer bag.
White powder odorless:
    1 gram of powder in a bag, ten packages in a box of cardboard.

pharmachologic effect

Hemostatic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Hemostatic drug, blocker of fibrinolysis.
The chemical formula is H2N (CH2) 5COOH.
It blocks the effects of plasminogen activators, inhibits the action of plasmin, and does not completely inhibit kinins. Has antiallergic activity and slightly strengthens the antitoxic function of the liver.

Pharmacokinetics

After oral administration, it is actively absorbed from the digestive tract. The greatest concentration in the blood is achieved after two hours. Quickly excreted in the urine, mostly in unchanged form. The elimination half-life is approximately 2 hours.

Indications for use

The use of the drug is justified with the following conditions and situations:
    prevention of bleeding with interventions on the liver, pancreas, lungs;
    prevention and treatment of menorrhagia and bleeding from the internal organs, mucous membranes, erosions of the stomach and intestines, as well as with menstruation;
    Hyperfibrinolysis of various genesis, including associated with the use of thrombolytic drugs and transfusion of canned blood products in large volumes;
    treatment and prevention of influenza and ARVI;
    for symptomatic treatment of bleeding caused by thrombocytopenia and inferiority of platelet function.

Contraindications

    Hypersensitivity to the components of the drug.
    Hematuria.
    Hypercoagulation, coagulopathy due to diffusion, intravascular disseminated coagulation, predisposition to thrombosis or thromboembolic diseases.
    Kidney disorders with excretory function disorder.
    Violations of cerebral circulation.
    Pregnancy or lactation.
It is recommended to use with caution the drug in valvular heart lesions, arterial hypotension, hematuria, cryptogenic bleeding from the upper urinary tract, liver failure, chronic kidney failure, age less than a year.

Side effects

Nausea, dizziness, headache, tinnitus, nasal congestion, diarrhea, decreased pressure, skin rash, convulsions, orthostatic hypotension, rhabdomyolysis, acute kidney failure, myoglobinuria, subendocardial hemorrhage.

Instructions for use Aminocaproic acid (Method and dosage)

Aminocaproic acid, instructions for the use of the solution
The solution is administered intravenously, drip. To achieve a quick action (for example, with acute hypofibrinogenemia), assign up to 100 ml of a 5% solution of 50-60 drops per minute for 20-30 minutes. In the first hour, add 4-5 grams of the drug (about 100 ml), and then, if necessary, 1 gram (about 20 ml) per hour for another 8 hours or until the final bleeding stops. If the bleeding continues or there is a repeat bleeding, then the drug is repeated every 4 hours.
In pediatric patients, the drug is administered at a rate of 100 mg per kilogram of body weight per hour, and then at a rate of 33 mg per kilogram of body weight per hour; the largest daily dose is 18 grams per square meter of body surface area.
Daily dose:
    for adults is 5-30 g;
    for children less than 1 year is 3 grams;
    for children 2-6 years is 3-6 grams;
    for children 7-10 years is equal to 6-9 grams;
    For children from 11 years old, adult doses are used.
For acute blood loss, the following dosages are used:
    Children under 12 months of age are given 6 grams of the drug;
    children 1-4 years of age, 6-9 grams of the drug;
    children of 5-8 years are injected 9-12 grams of the drug;
    Children of 9-10 years are injected 18 grams of the drug.
The duration of treatment varies between 3-14 days.

Aminocaproic acid, instruction on the use of powder

Having dissolved the powder in water, it is taken orally after or during a meal. The daily dose for adult patients is divided into 3-6 receptions, and for patients of children's age - for 3-5 receptions.
With an average degree of increase in fibrinolytic activity, the drug is usually prescribed in a daily dose of 5-23 grams. Children under the age of 1 year are prescribed a one-time dose of 0.05 grams per kilogram of weight (but not more than 1 gram). Daily dosage for children: up to 1 year is 3 grams, 1-7 years - 3-6 grams, 7-11 years - 6-9 grams. For adolescents (over 11 years), the highest daily dose is 10-15 grams.
In the treatment of acute bleeding, first prescribe 5 grams of the drug, and then 1 gram once a hour (not more than 8 hours) until the final stop of bleeding. The daily dosage for children of children with acute blood loss: up to 1 year is 6 grams, 1-5 years - 6-9 grams, 5-9 years - 9-12 grams, 10-11 years - 18 grams.
In the treatment of subarachnoid hemorrhages, 6-9 g of the drug are prescribed.
In the treatment of traumatic hyphema, the drug is recommended at a dose of 0.1 grams per kilogram of body weight every four hours (up to 24 grams per day in total) for 5 days.
With uterine bleeding (metrorrhagia) associated with intrauterine contraceptives, and with monthly appoint 3 grams of medication every 6 hours.
To prevent and stop bleeding with dental procedures, adults are recommended to take 2-3 grams of medication up to 5 times a day. For adults, the average dosage is 10-18 grams of medication, and the maximum allowable - 4 grams. Duration of treatment is 3-14 days.
With the flu and acute respiratory viral infection, the drug is administered orally and topically. To apply 1 gram of the preparation inside, a little bit of sweet boiled water is diluted in 2 tablespoons, resulting in a 5% solution.
Inside such a solution is prescribed in dosages:
    children under two years of 1-2 teaspoons (1-2 grams) four times a day, they are allowed to add to drinks or to food;
    children 2-6 years 1-2 tablespoons (2-4 grams) four times a day;
    children 6-10 years of 4-5 grams per day;
    patients older than 10 years are prescribed 1-2 grams up to 5 times a day.

Aminocaproic acid in the nose

It is also recommended to use the drug Aminocaproic acid in the nose (child or adult), locally. When laying for 10 minutes in the nasal passage of cotton turundum every 3 hours, pre-moistened with a solution of 5% aminocaproic acid, or observing the specified multiplicity, instill 4-5 drops of solution into the nasal passages. The drug can be used for inhalations for children and adults. In such cases, a nebulizer may be used for inhalations to the child.
In case of severe hypertoxic types of influenza or acute respiratory viral infection, the dosage of the drug is allowed to be raised to the maximum recommended at this age with a moderate increase in fibrinolytic activity.
Aminocaproic acid, if necessary, can be used in combination with other antiviral drugs, interferon-containing agents and interferon inducers.
Intranasal instillation of aminocaproic acid up to four times a day is advisable during the epidemic period for prevention.
The duration of therapy depends on the severity of the disease and is determined by the individual doctor.

Overdose

Signs of an overdose: increased undesirable effects, the appearance of blood clots. With prolonged use (over 6 days) of large doses (from 24 grams per day for adults), the development of hemorrhages is not ruled out.
Treatment of overdose: withdrawal of medication, symptomatic therapy.

Interaction

The drug is able to combine with the use of solutions of glucose, hydrolysates, antishock solutions.
Do not add other medicines to the solution of the drug.

Storage conditions

Store in a dry, dry place at a temperature of 2-25 ° C. Keep away from children.
Shelf life - 3 years.

special instructions

When using the drug, it is recommended to measure the indices of fibrinolytic activity and the content of fibrinogen in the blood. With intravenous administration, a coagulogram is recommended, especially after a heart attack, with ischemic disease and liver disease.

Children

The use of the drug is allowed for children for inhalation, instillation, ingestion and intravenous administration in the above dosages.

In pregnancy and lactation

The drug is prohibited for use in pregnant and lactating women, as well as during labor.

Reviews about Aminocaproic Acid

Reviews of the drug from doctors and patients report the extensive use of this drug in many clinical situations: to stop bleeding during surgery, in the prevention of ARI, locally to stop bleeding. The drug rarely causes side effects, but it can only be used according to the doctor's prescription.
The recipe in Latin for the preparation of aminocaproic acid should contain the name Acidi aminocapronici 5%.