Nemozole tabs 400mg #1

Nemozole user manual

You can buy Nemozole here

Composition

Pills Nemozole in p/o contain 0.4 g of albendazole, maize starch, povidone-30, purified talc, sodium lauryl sulfate, gelatin, silica (in colloidal form), sodium starch glycolate, methyl - and propylparaben, magnesium stearate. Composition of p / o: titanium dioxide, hydroxypropylmethyl cellulose, propylene glycol; methylene chloride and isopropanol (evaporate when dried).
Nemozole chewing tablets contain 0.4 g of albendazole, corn starch, povidone-30, purified talc, sodium lauryl sulfate, silicon dioxide (colloidal), gelatin, citric acid, methyl and propylparaben, sodium starch glycolate, aspartame, magnesium stearate, flavors (pineapple/mint).
The composition of the slurry Nemozole albendazole is included at a concentration of 20 mg/ml Auxiliary substances: microcrystalline cellulose, carboxymethylcellulose sodium, sorbitol solution, benzoic acid and sorbic acid, glycerin (glycerol), potassium hydrochloride, Polysorbate-80, fragrance (essence of ice cream/mixed fruit flavour), purified water.

Form release

pills to 0.4 g (chewable and p/o);
oral suspension 100 mg / 5 ml.
Tablets are packaged in contour packaging one in each pack one pack. The suspension is available in bottles of 20 ml.

Pharmacological action

Antiparasitic, anthelmintic.

Pharmacodynamics and pharmacokinetics

Contained in Nemozole albendazole (Albendazole) is with broad spectrum antiparasitic agent.
The main mechanism of action of the substance is related to its ability to suppress the polymerization of beta-tubulin protein.
This leads to the fact that in the cells of the intestinal tract of helminths, the activity of the cytoplasmic microtubular system is disturbed; the course of biochemical processes in the organisms of parasites changes; in the muscle cells of nematodes, the movement of secretory granules and other organelles is blocked.
The result of this action is the death of parasites.
The most effective against the larvae of tapeworms (pork tapeworm and Echinococcus), and also against roundworms Strongyloides stercolatis (ugrica intestinal).

Pharmacokinetics

From the digestive tract, the substance is absorbed poorly in the plasma in unchanged form is not found. Characterized by low bioavailability (about 30%).
To increase absorption and value Cmax (5 times) contributes to the drug simultaneously with fatty foods.
The substance is rapidly biotransformation in the liver. The primary metabolite (M1) is albendazole sulfoxide, which also has an anthelmintic activity.
Dmah M1 varies from 2 to 5 hours. About 70% of albendazole sulfoxide is in the plasma protein-bound state. The substance is almost completely distributed throughout the body; it is determined in the liver, bile, urine, cystic fluid and the wall of the cyst, cerebrospinal fluid.
M1 in the liver is converted to albendazole sulfone (M2), and other oxidized products. T1 / 2 M1 — from 8 to 12 hours. Excreted by kidneys in the form of various metabolic products.
If renal function is impaired, the excretion of albendazole and M1 does not change.
When impaired liver function increases the bioavailability of the substance and Cmax M1 (2 times), and lengthened T1/2.
Albendazole helps to increase the activity of microsomal enzymes of CYP system; accelerates metabolism of many drugs.

Indications for use

The drug is used for treatment:
of nematodes (hookworm, ascariasis, trichuriasis, necatoroz, enterobiasis);
strongyloidiasis's;
toxocariasis';
giardiasis's;
of neurocysticercosis, the causative agent of which are armed larvae (pork) tapeworm;
hydatid disease of the peritoneum, lung and liver, they are caused by larvae of the tapeworm Echinococcus;
mixed worm infestations.
It is also advisable to use the drug as a Supplement to the basic treatment for surgical interventions to remove echinococcal cysts.

Contraindications

The use of Nemozole contraindicated in patients with lesions of the retina, hypersensitivity to any component tablets/suspension during pregnancy.
Relative contraindication:
disorders of hematopoiesis;
liver dysfunction (before and during treatment requires regular monitoring of the functional state of the body);
lactation.

Side effect

Side effects of the drug may appear in the form of:
disorders of liver function in which there is an increase (weak / moderate)
transaminase activity;
nausea/vomiting;
pain in the abdomen;
oppression of bone marrow hematopoiesis (agranulocytosis, leukopenia, pancytopenia, granulocytopenia, thrombocytopenia);
dizzinesses;
headache;
clinical signs of irritation of the membranes of the brain (meningeal symptoms).
alopecia (reversible);
skin eruption;
itch;
hyperthermias;
increase in blood pressure;
hypersensitivity reaction;
acute renal failure.

Instructions for use of Nemozole (Method and dosage)

Suspension Nemozole, instructions for use

The medicine is taken orally with meals. To increase the bioavailability of albendazole, it should be taken with fatty foods.
Nemozole for children 12-24 months with ascariasis, hookworm, trichinosis, enterobiasis, necatoroz shown a single dose of 1 dessert spoon suspension (10 ml).
Recommendations on how to take medication for children over the age of two are as follows:
ascariasis, hookworm, trichinosis, enterobiasis, necatoroz — child once give 20 ml (to take Nemozole from worms, it is recommended to all persons living together).
With teniosis and strongyloidosis, the suspension for children is given 1 p. / day for 20 ml for 3 days.
When toxocarosis is indicated reception 20 ml suspension 1 p. / day for 10 days.
When polivalentes caused by infestation of the body Clonorchis sinensis (Chinese Fluke), and Opisthorchis viverrini (a Fluke of Viverra), patients are advised for 3 days twice a day to give 20 ml of suspension.
Treatment of giardiasis in children aged 2 to 12 years is carried out with a dose of 20 ml/day. (the medicine is taken at a time). The course lasts 5 days.
Adult patients Nemozole giardiasis, ascariasis, hookworm, strongyloidiasis, trichinosis, enterobiasis, necatoroz, toxocariasis, teniasis and polygermanes prescribed to take on a similar scheme.
In cystic / alveolar echinococcosis, as well as in neurocysticercosis patients whose weight is more than 60 kg, the drug is given twice a day for 20 ml.for patients whose weight is less than 60 kg, the recommended daily dose of albendazole is 15 mg/kg, divided into 2 admission. The highest dose of 800 mg/day..
The course of treatment for cystic echinococcosis is designed for 28 days.14 days treatment can be repeated. If necessary, may be conducting 3 courses.
In alveolar echinococcosis patient is prescribed the application of Nemozole for 3 courses at 28 days with a 14-day interval between courses.
In neurocysticercosis treatment lasts from 1 week to 30 days. Repeated course is possible after 14 days.
With creeping rash, the suspension is taken at 20 ml 1 p. / day for 1-3 days.

Pills Nemozole, instructions for use

The tablets are taken orally with food (preferably fatty foods, as this increases the bioavailability of albendazole).
For children over three years of age, adolescents and adults, the instructions provide the following guidance on how to take the drug:
ascariasis, hookworm, trichinosis, enterobiasis, necatoroz — 1 tab./day. for one time.
With teniosis and strongyloidosis, the tablets are given one p. / day for 3 days.
When toxocariasis pills take one 1 p/day for 10 days.
When mixed helminthiasis, caused by infestation of the body Clonorchis sinensis (Chinese Fluke), and Opisthorchis viverrini (a Fluke of Viverra), patients are advised for 3 days twice a day take one tablet.
For the treatment of giardiasis adults and children over 3 years the patient is given 1 tablet of Nemozole a day for 5 days.
In cystic / alveolar echinococcosis, as well as in neurocysticercosis patients, whose weight is more than 60 kg, the drug is given twice a day for 1 tablet. For patients whose weight is less than 60 kg, the recommended daily dose of albendazole is 15 mg / kg, divided into 2 admission. The highest dose of 800 mg/day..
The course of treatment for cystic echinococcosis is designed for 28 days.14 days treatment can be repeated. If necessary, may be conducting 3 courses.
In alveolar echinococcosis patient is prescribed the application of Nemozole for 3 courses at 28 days with a 14-day interval between courses.
In neurocysticercosis treatment lasts from 1 week to 30 days. Repeated course is possible after 14 days.
With creeping rash, the tablets are taken one per day for 1-3 days.
It should be remembered that the pill worms recommended to drink at the same time all residents together.

How fast acting Nemozole?

Reviews about Nemozole for children and adults suggests that the parasites after ingestion usually go during the week. After 3 weeks of treatment, it is recommended to make a repeated analysis of feces.

Overdose

In case of overdose, the patient is shown gastric lavage, administration of enterosorbent (activated charcoal) and, if necessary, symptomatic treatment.

Interaction

The concentration of the active metabolite albendazola increases with the simultaneous use of the drug with Cimetidine and Dexamethasone.

Terms of sale

To buy Nemozole you don't need a prescription.

Storage conditions

Regardless of the form of release, the drug should be stored at temperatures up to 25 º C in a place protected from moisture and light.
Shelf life - three years.

Special instruction

During treatment with the drug, it is necessary to monitor changes in the cellular composition of the blood (leukocyte level is checked before treatment and then every 2 weeks of the cycle) and the activity of liver enzymes.
If the result of the application of Nemozole have patient developed leukopenia, treatment should be suspended. The course can be continued only if the degree of decrease in the concentration of neutrophils and leukocytes is insignificant, and leukopenia does not progress.
If the indicators in liver enzymes greater than the upper limit of normal by more than half, the use of Nemozole stop to their full normalization.
In neurocysticercosis, the drug is prescribed in combination with anticonvulsants and GCS. Oral and parenteral forms of corticosteroids in the first week of application of Nemozole are used to prevent attack of hypertension.

Nemozole for children

Suspension in pediatric practice is used from 12 months, tablets - from 3 years.

Nemozole and alcohol

Nemozole and alcohol are incompatible.

At pregnancy

During pregnancy / lactation the use of albendazole is contraindicated. If necessary, the appointment of the drug nursing women, breastfeeding should be discontinued.
To prevent the application of Nemozole in the early stages of pregnancy women of childbearing age treatment should begin only after exclusion the fact of pregnancy.
During the period of suspension/tablets reliable contraception should be provided.

Reviews about Nemozole

Reviews of doctors about the drug Nemozole, allow us to conclude that it is a cure for worms, today is one of the best. The agent disrupts the course of biochemical processes in the body of parasites, causes destruction of their cell membranes and as a result — to the death of helminths.
The drug is distributed on the larvae of tapeworms (armed, dog), Giardia, whipworm, pinworm, opistorchis, Ascaris, necator americanus intestinal ugritsy, microsporidia, Toxocara. Effective Nemozole when polivalenta.
The manufacturer produces it in the form of tablets and suspensions: the tablets are the optimal dosage form for adults, the suspension is prescribed for children over 12 months old.
Most people leave good reviews about Nemozole on the forums. Because most helminth infection occur in childhood, mostly reviews about Nemozole for children. Almost all mothers note the speed of the drug and its effectiveness, but emphasize that some patients may have side effects.