Ventolin nebuls 1mg/ml #20

Ventolin instruction

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Composition

The active substance of this drug is salbutamol sulfate. In addition, it contains tetrafluoroethane - 1 dose.

Form of issue

In pharmacies you can find Ventolin aerosol (Ventolin inhaler). In addition, Ventolin in nebula is sold as a solution for inhalation. Also, the medicine can be found in tablets and in the form of syrup.

pharmachologic effect

Bronchodilator.

Pharmacodynamics and pharmacokinetics

The drug is used to prevent bronchospasm. It is a bronchodilator, or rather a selective beta-2-adrenomimetic. It increases the vital capacity of the lungs and mucociliary clearance, activates the ciliary epithelium, improves the secretion of mucus, dilates the coronary arteries, reduces the potassium content, acts as a hyperglycemic and lipolytic agent, affects glycogenolysis and insulin release, increases the risk of acidosis.
The medicine works quite quickly, almost 5 minutes after application (maximum - after 30-90 minutes). The duration of the effect is about 5 hours.
10-20% of salbutamol after application are in the lower parts of the respiratory tract. They are absorbed into the lung tissue and blood, but do not split. The remaining amount of active substance is retained in the inhaler or in the oropharynx, after which it is swallowed and actively cleaved when passing through the liver with conversion to phenolic sulfate.
The degree of connection with plasma proteins is about 10%.
Entered into the blood, salbutamol is cleaved within 72 hours in the liver and is excreted mainly with urine in the form of phenolic sulfate or in an unchanged state. A small part is excreted with feces.

Indications for use

The inhaler and solution for it with Ventolin are used for bronchitis in chronic form, bronchial asthma and COPD with reversible airway obstruction.

Contraindications

The medicine can not be used for chronic heart failure, hypersensitivity to components, pregnancy, childhood up to 18 months, breast-feeding.

Side effects

As a rule, among side effects, finger tremor, headache, and anxiety are noted. In addition, the following undesirable reactions are possible:
    hypersensitivity in the form of urticaria, hypotension, Quincke edema, bronchospasm, collapse;
    hyperactivity;
    paradoxical bronchospasm;
    muscle cramps;
    hypokalemia;
    lactic acidosis;
    tachycardia;
    strong palpitations;
    expansion of peripheral vessels;
    arrhythmia;
    extrasystole;
    supraventricular tachycardia;
    irritation of the mucous membrane of the mouth and pharynx.

Instructions for use Ventolin (Method and dosage)

Instructions for use Ventolin warns that the medicine should be used correctly, regardless of the form of release, otherwise the treatment process may go wrong.
In addition, the drug must be taken only after consulting a doctor.
Instructions for Ventolin for inhalation in the form of an aerosol informs that for use of the drug it is necessary to use a nebulizer with a mask and an endotracheal tube.
Ventolin Nebula, which is sold in the form of a solution for an inhaler, is used without dilution. The duration of the inhalation is about 10 minutes. The drug can be diluted with a sterile solution of sodium chloride (0.9%). It should be used in well ventilated rooms, as some of the drug enters the environment.
Instruction for Ventolin Nebulas for inhalations recommends a dose of 2.5 mg. If necessary, it can be increased to a maximum of 5 mg. The frequency of use is 3-4 times a day. For adult patients, if necessary, in a hospital, the dosage rises to 40 mg per day.

Overdose

When the drug is used in doses above the norm, hypokalemia, tachycardia, nausea, lowering of blood pressure, muscle tremor, vomiting, agitation, respiratory alkalosis, headache, hyperglycemia, hypoxemia are possible. In rare cases, hallucinations, tachyarrhythmia, widening of peripheral vessels, convulsions, fluttering of the ventricles appear.
For treatment, cardioselective beta-blockers are used, but with caution, if there is an episode of bronchospasm in the anamnesis.

Interaction

Ventolin for inhalations is not recommended for use with non-selective beta-adrenergic blockers. In patients with thyrotoxicosis, this agent also increases the effect of stimulants of the nervous system and tachycardia.
If you combine aerosol and a solution for inhalation with xanthines, the probability of tachyarrhythmia increases. With Levodopa and the means for inhalation anesthesia, the risk of developing severe ventricular arrhythmia increases. Together with anticholinergic drugs, intraocular pressure may increase. When administered with diuretics and GCS, hypokalemic effects increase.

Storage conditions

Keep the medicine in a place inaccessible to children and well protected from light. It can not be frozen or heated, the optimum temperature is not higher than 30 ° C.

Shelf life

The drug should be stored for no longer than 2 years.

Children

Inhalation of children can be used to relieve bronchospasm attacks in a dosage of 100-200 μg (1-2 inhalations). Maintenance therapy Ventolinom - up to 200 mcg 4 times a day (2 inhalations). For prophylaxis, 100-200 μg is used for 10-50 minutes before the provoking factor (1-2 inhalations).
Spacers "Babihaler" or "Volumatic" are used for children.
The clinical efficacy of this drug in children under 18 months of using a nebulizer has not been investigated.

Reviews of Ventolin

Reviews of Ventolin in nebulae, as well as aerosol, are mostly positive. Patients note its speed. Only a few complain about side effects and addiction. For those who are interested, hormonal or not this drug, doctors unequivocally answer that it is not hormonal, however, do not recommend using it without a special purpose.