Baclosan tabs 10mg #50

Baclosan instruction

You can buy Baclosan here

Composition

One tablet of the drug contains 25 mg or 10 mg of baclofen as an active substance.
Excipients: lactose, gelatin, potato starch, magnesium stearate, talc, ethyl cellulose.

Form of issue

Baclosan is a biconvex, round, with a separating strip of white tablets. 50 such tablets in a polypropylene jar, one such jar in a paper bundle.

pharmachologic effect

Miorelaksiruyuschy and antispastic effects are typical for the drug.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Baclosan is a central muscle relaxant; inhibitor of GABAB-receptors. Reduces the excitability of the distal sections of the nerve impulses of sensitive fibers and depresses the intermediate cells of the nervous system. As a result, the synaptic transmission of impulses is suppressed; reduction in muscle fiber tension. The drug does not affect the transmission of nerve impulses in the musculoskeletal synapses.
In diseases characterized by a pathological permanent contractility of skeletal muscles, the drug Baclosan facilitates cramps and painful spasms. The drug increases the amplitude of movements in the joints, simplifies the conduct of kinesitherapy (massage, gymnastics, manual therapy).

Pharmacokinetics

After taking Baclosan tablets, they are adsorbed in the intestines of a high degree. The maximum concentration in the blood is observed three hours after the application of the drug.
The binding with plasma proteins reaches 30%. The drug penetrates the placental barrier, is excreted in breast milk. Metabolism occurs in the liver. It is excreted in the urine in its original form.

Indications for use

The drug is used in connection with the increase in muscle tone with:
    pathology of the spinal cord (tumors, trauma, syringomyelia, motor neuron disease);
    Multiple sclerosis;
    cerebral palsy;
    cerebrovascular diseases;
    meningitis;
    head trauma.

Contraindications

Contraindications to the use of Baclosan are:
    Parkinson's disease;
    psychoses;
    convulsions (including in the past);
    epilepsy;
    lactose intolerance, lactase deficiency, malabsorption;
    a stomach ulcer or duodenal ulcer;
    pregnancy;
    lactation period;
    an allergy to the components of the drug.
Baclosan is used with caution in cases of insufficient blood supply to the brain, atherosclerosis of cerebral vessels, kidney failure, in the elderly and children under the age of three.

Side effects

    From the musculoskeletal system: myalgia.
    From the nervous system: weakness, dizziness, gait disturbance, insomnia, sedation, depression, euphoria, asthenia, tremor, hallucinations, nightmares, nystagmus, paresthesia, dysarthria.
    On the part of the respiratory system: respiratory depression.
    From the cardiovascular system: reduction of cardiac output, hypotension.
    On the part of the organs of vision: visual disturbances.
    On the part of the digestive system: diarrhea, constipation, dyspepsia, nausea, abdominal pain, liver damage.
    On the part of the genitourinary system: enuresis, polyuria, urinary retention, sometimes - erectile dysfunction.
    From the skin: hyperhidrosis.
    General violations: lowering of temperature.
In extremely rare cases, an increase in spasms was detected, which was estimated as a paradoxical effect of taking the drug.

Instructions for use Baclosan (Method and dosage)

Instructions for use Baclosan recommends taking the drug orally with food. If one mistake was missed, the next time you do not use a double dose.

Adults

The starting dose is 5 mg (half a tablet 10 mg) three times a day, with an increase in the dose of 5 mg every three days and so until the therapeutic effect (usually enough 30-75 mg per day). The maximum daily dose is 100 mg.
The final dose should not reduce muscle tone, lead to severe myasthenia, or worsen motor functions.
With renal failure or during hemodialysis, the daily dose is 5 mg.
In people over 65 years of age, the dose should be increased with caution, since they have a high risk of side effects.

Children

The starting dose is 5 mg three times a day. If necessary, the dose can be increased every 3 days by 5 mg until a therapeutic effect appears.
Recommended doses: for children aged 3-6 years - 20-30 mg / day; 6-10 years - 30-60 mg / day; over 10 years the maximum daily dose is 2.5 mg / kg of mass, the starting dose is 1.5-2 mg / kg of mass.
The drug is withdrawn slowly (within 10-14 days).

Overdose of Baclosan

Symptoms of overdose: respiratory depression, muscle hypotension, coma, confusion.
Treatment: abundant use of fluid, the use of diuretics, with the suppression of respiratory function - artificial ventilation. The antidote is unknown.

Interaction

When combined, Baclosan activates the effect of drugs that affect the nervous system, lowering blood pressure, antidotal drugs, alcohol.
With the simultaneous administration of Baclosan with tricyclic antidepressants, a pronounced decrease in muscle tone develops.
Do not take Baclosan with carbidopa and levodopa, as confusion and hallucinations may occur.

Storage conditions

Keep away from children. Store in a dry, dark place at a temperature of not more than 25 degrees.
Shelf life - Three years.

special instructions

Side effects of Baclosan are often temporary, they need to be differentiated with the symptoms of the underlying disease.
People with diabetes and liver disease are recommended to regularly monitor the level of transaminases, alkaline phosphatase and glucose in the blood.
Patients undergoing therapy with Baclosan should refrain from occupations associated with increased attention and reaction.

Children

Children younger than 12 years are appointed with caution.

With alcohol

Baclosan significantly increases the negative effects of alcohol, so for the period of drug treatment should refrain from taking alcohol-containing drinks.

In pregnancy and lactation

Baclosan is contraindicated in pregnancy and lactation.

Reviews about Baclosan

Recommendations and reviews about Baclosan testify - the majority of patients remained rather the results of application of the drug. It is rare to read negative reviews about the Baclosan tablets, associated with the occurrence of side effects.
A number of narcological clinic patients often use the drug in combination with some drugs. Baclosan in this case is capable of triggering trip or "arrival". It is known that such use of the drug results in the development of dependence.

How to get off Baclosan?

This is often asked by the patients question. If the withdrawal syndrome is caused by the use of the drug in the recommended doses, then the discontinuation should be done gradually within two weeks. If there is a dependence as a result of unauthorized use of the drug to achieve a drug effect, then you need to seek help from a doctor-narcologist.