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Betahistinum tabs 24mg #20

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Betahistinum user manualYou can buy Betahistinum tabs on this pageCompositionThe main active substance is Betahistinum dihydrochloride.Auxiliary components:    sodium croscarmellose;    sodium lauryl ..

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Betahistinum user manual

You can buy Betahistinum tabs on this page


The main active substance is Betahistinum dihydrochloride.
Auxiliary components:
    sodium croscarmellose;
    sodium lauryl sulfate;
    microcrystalline cellulose;
    citric acid;
    magnesium stearate.

Form of issue

    Tablets are flat-cylindrical round form of white color with marked marking indicating the dose of active substance (8 mg).
    Tablets oblong biconvex with rounded edges with a marked on the surface, indicating the dose of active substance content - 16 and 24 mg, respectively.

pharmachologic effect

Betahistinum is an analog of histamine, created by a synthetic method. In general, the active substance of the drug is able to use histamine H-1 and H-3 receptors (weak and strong antagonists) of the central nervous system. In this case we have in mind the receptors of the inner ear and vestibular nuclei.
Betagistine dihydrochloride acts on the bloodstream, stimulating the microcirculation and permeability of the inner ear capillaries. In addition, the active substance of this drug stabilizes the pressure of the endolymph in the cochlea and labyrinth.
Due to the fact that Betahistinum is essentially an inhibitor of the H-3 receptors of the nuclei of the vestibular apparatus, this drug has a pronounced effect on the CNS, stabilizing the neuronal transmission in neurons of the vestibular nucleus.
Betahistinum, when properly administered, can very quickly neutralize the symptoms of vestibular vertigo. The period of exposure to the active substance of this drug is from a few minutes to 24 hours. Regular reception of Betahistinum under the supervision of a doctor will reduce the frequency and effectiveness of dizziness, reduce the noise and ringing in the ears in patients, and restore hearing in case of worsening. The drug does not have a sedative effect and does not cause various coordination disorders. Does not affect the endocrine glands.

Pharmacodynamics and Pharmacokinetics

Betahistinum is rapidly and completely absorbed after oral administration of the drug in tablets. Peak concentrations in the plasma of the active substance of the drug are achieved approximately one hour after oral administration on an empty stomach. Subsequently, Betahistinum binds to human plasma proteins, but it is worth noting a very low level of communication - less than 5%.
In plasma, the maximum concentration of the active substance is reached after about 60 minutes. It is excreted from the body as a result of metabolism by metabolizing to inactive metabolites - 2-pyridylacetic acid (the main metabolite) and demethylbetahistine.
Almost complete elimination of drug substances occurs during the day mainly through the kidneys (approximately 90%), the remaining 10% are excreted through the intestine and liver.

Indications for use Betahistinum

Very often on the Internet forums, users ask the question: "From what Betahistinum?".
Indications for use of Betahistinum are as follows: treatment of Ménière syndrome, as well as symptoms that may include dizziness, tinnitus, partial hearing loss, nausea, impaired coordination.
Help: Meniere's syndrome manifests itself in the form of vestibular and auditory disorders, previously not observed in humans. Can develop as an acute stroke. Has a high probability of subsequent relapse.


Betahistinum is contraindicated in patients with pheochromocytoma. Since this drug is a synthetic analog of histamine, its administration can cause the release of catecholamines, which leads to severe hypertension.
In addition, taking Betahistinum is contraindicated if the patient has an increased sensitivity to the active substance or to any of the excipients that make up the drug.

Side effects

Along with the obvious beneficial effects, taking Betahistinum can provoke the manifestation of side effects.
Attention: not every patient taking this medication will experience discomfort, and observe the manifestation of at least one of the side effects listed below.
Experts warn that the manifestation of side effects when taking any medication is not always treated in a negative way. As a rule, in most cases, any reaction can mean adaptation of the body to a new drug, so before deciding to refuse to take the medicine, you should consult a doctor.
Common side effects from taking Betahistinum are observed in one in ten patients who take this medication. The list of the most common side effects includes such symptoms as:
    general poor health;
    upset stomach (occurs when taking the drug before meals, which is strictly contraindicated);
    headache (in this case it is necessary to take an analgesic, according to the preliminary recommendation of a specialist);
    bloating or discomfort;
    allergic skin reactions, such as pruritus and rash (when developing such reactions, use an antihistamine or anoint skin with moisturizer cream).
In case these recommendations do not help to eliminate side effects, the patient should definitely consult a doctor before taking another dose of Betahistinum.

Instructions for use Betahistinum

Betahistinum should be taken strictly in accordance with the instructions.

Dosage for adults:

Dizziness tablets should be taken with food or after meals at a dosage of 8 or 16 mg three times a day at the initial stage of treatment with this drug.
Supportive drug doses generally range from 24 to 48 mg per day at the discretion of the treating physician. The daily dose should not exceed 48 mg. Dosage can be adjusted taking into account the individual characteristics of the patients' health. Sometimes improvement can be observed only after several weeks of treatment.
Treatment of patients with hepatic, renal and heart failure:
For patients with hepatic insufficiency, treatment with Betahistinum should be given after a thorough examination. The treatment of patients with renal and heart failure is also prescribed.
Treatment of elderly patients:
In the elderly, Betahistinum should be used with caution, since in this population there is a high probability of negative reactions from the body to the active ingredients and excipients that make up the drug.
Betahistinum, instruction for children and adolescents:
Betahistinum tablets are not recommended for use in children and adolescents less than 18 years of age due to lack of safety and efficacy data.


General information on cases of overdose with Betahistinum was not reported. It is known that some patients experienced mild and moderate symptoms in the form of headache, nausea, drowsiness and pain in the abdominal area when taking the drug at a dose of up to 640 mg.
Other symptoms of overdose: vomiting, indigestion, ataxia and convulsions.
More serious complications: seizures, pulmonary or cardiovascular complications were observed in cases of deliberate drug overdose, especially in combination with other medications. There is no specific antidote, therefore, in case of an overdose with this medicine, gastric lavage is recommended within one hour after administration.

Interaction with other drugs

Currently, there are no proven cases of dangerous drug interactions.

Storage conditions

This drug should be stored at room temperature, not exceeding 25 ° C, away from moisture and heat. It is recommended to keep the tablets in an airtight container.
Shelf life 2 years. At the expiration of the expiration date, it is strictly forbidden to take tablets in order to avoid negative manifestations on the part of the organs and systems of the body.

Reviews about Betahistinum

As in the case with all medicines, reviews about Betagistine are not always positive. At specialized forums very often you can meet reviews about the drug, which speak about not always a stable effect. In this connection, most people suffering from chronic cardiovascular disorders are forced to take these tablets regularly. But this does not guarantee getting rid of headaches and dizziness.
Nevertheless, there are many positive comments. For example, several women wrote that during the onset of menopause, they began to experience wild headaches and dizziness attacks, which did not allow them to even slightly tilt their head down, because at these moments they lost coordination completely. After the appointment of Betahistinum these symptoms disappeared completely, there was clarity of mind and lightness throughout the body.
Both positive and negative reviews suggest that this drug requires very fine application - with some violations it can completely restore health, while in others, on the contrary, it will not have the expected effect, but will only reduce the manifestation of symptoms.

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