Depakine Chrono 300mg #100

Depakine Chrono instruction

You can buy Depakine Chrono online

Composition

Active substances of the preparation: sodium valproate and valproic acid.
In addition, Depakine Chrono 300 mg contains the following additional components: hypromellose 4000, sodium saccharinate, talc, polyacrylate dispersion 30%, ethylcellulose, macrogol 6000, titanium dioxide, hypromellose.
Depakine Chrono 500 mg, in turn, has such auxiliary ingredients as hypromellose 4000, silicon dioxide colloidal anhydrous, titanium dioxide, sodium saccharinate, talc, silicon dioxide colloid hydrated, macrogol 6000, ethylcellulose, hypromellose, polyacrylate 30%.

Form of issue

Tablets in a shell, odorless or with a faint smell. The form is oblong.

pharmachologic effect

Anticonvulsant for epilepsy.

Pharmacodynamics and pharmacokinetics

Tablets are an anticonvulsant that is effective in various forms of epilepsy.

Two mechanisms of its action are known:

    valproic acid affects the GABA-ergic system. It increases the concentration of GABA in the central nervous system and stimulates GABA-ergic transmission;
    the influence of valproate metabolites remaining in the brain is possible. After excretion of the drug, the level of GABA increases.
Bioavailability of the drug for oral administration is approximately 100%. Mainly, the volume of distribution is limited to blood and extracellular fluid. The active substance penetrates the brain and cerebrospinal fluid.
The elimination half-life is 15-17 hours. The minimum concentration of the drug in the serum is 40-50 mg / l. The maximum concentration is 200 mg / l, at a higher level it is necessary to reduce the dosage.
Stable concentration in plasma - after 3-4 days of use. Strong bonds with plasma proteins, which depend on the dosage. It is excreted mostly with urine.

Indications for use

Adult patients are prescribed this remedy for treatment:
    the Lennox-Gastaut syndrome;
    generalized and partial epileptic seizures;
    bipolar affective disorders.
Children are given Depakine Chrono for treatment:
    partial and generalized epileptic seizures;
    the Lennox-Gastaut syndrome.

Contraindications

The drug can not be used when:
    hypersensitivity to the components of the drug;
    chronic hepatitis;
    hepatic porphyria;
    body weight less than 17 kg;
    acute hepatitis;
    Mefloquine and / or St. John's wort extract;
    children under 6 years.

Side effects

When taking the drug, the following side effects are possible:
    diarrhea;
    allergic reactions;
    vomiting;
    Stevens-Johnson syndrome;
    decrease in the level of fibrinogen;
    confusion of consciousness;
    increased bleeding time;
    slight hand tremor;
    vasculitis;
    increase in body weight;
    reversible Fanconi syndrome;
    polymorphic erythema;
    nausea;
    stomach ache;
    moderate hyperamonia;
    thrombocytopenia;
    hair loss;
    drowsiness;
    headache.
Symptoms are usually reversible and go away after the drug is discontinued.
In addition, in rare cases, the following side effects are possible:
    reversible parkinsonism;
    toxic epidermal necrosis;
    lethargy, which in some cases leads to a transient coma;
    macrocytosis;
    pancytopenia;
    impaired kidney function;
    amenorrhea;
    impaired liver function;
    stupor;
    reversible dementia;
    anemia;
    leukopenia;
    loss of hearing;
    violation of the regularity of the menstrual cycle;
    peripheral edema.

Instructions for use Depakine Chrono

Tablets of 300 mg and 500 mg are for oral use. The daily dosage is divided into 1 or 2 doses. Once a day, the drug can be used with well-controlled epilepsy. Instructions for use Depakine Chrono recommends taking pills while eating.
Dosage depends on the age and weight of the patient, as well as on his individual tolerance of the components.
Adults and children aged 6 years (weighing above 17 kg) are usually prescribed an initial dose of 10-15 mg / kg, gradually it is raised to the desired. The average dosage is 20-30 mg / kg per day. If the therapeutic effect is not available, it can be increased, but careful monitoring of the patient's condition is necessary.
It is desirable not to crash tablets and not to chew. If they are used as a substitute for other antiepileptic drugs, dosages should be administered gradually, the average dose is reached, therefore, within 2 weeks. Reception of the withdrawn preparation also decreases step by step.
If no other antiepileptic drugs have been taken before, the Depakine Chrono dosage is increased every 2-3 days until optimal (it will take about a week).
Other anticonvulsants in the background of Depakine Chrono should also be administered in stages.

Overdose

In acute overdose, a coma with hypotonia of the muscles, miosis, metabolic acidosis, hyporeflexia and respiratory depression is possible.
In addition, there are cases of increased intracranial pressure due to cerebral edema. Possible and fatal outcome.
As a treatment, gastric lavage is used, carefully monitor the cardiovascular and respiratory systems, maintain an effective diuresis. In serious situations, dialysis is performed.

Interaction

It is not recommended to take Depakine Chrono simultaneously with funds that can provoke convulsions or reduce the convulsive threshold.
Strictly contraindicated combination with:
    Mefloquine;
    St. John's wort.
It is not recommended to combine the drug with Lamotrigine, since there may be undesirable side effects.

With caution should take Depakine Chrono with:

    Carbamazepine;
    Felbamate;
    Phenytoin;
    Nimodipine;
    Carbapenem;
    Monobactams;
    Phenobarbital;
    Primitone;
    Topiramate.
When combined with these drugs requires strict medical supervision.

Storage conditions

Keep the drug out of the reach of children, dry place. It is advisable not to get it out of the package. The optimum temperature is not higher than 25 ° С.

Shelf life

Depakine Chrono is kept for 3 years.

Reviews about Depakine Chrono

Reviews about Depakine Chrono, as a rule, are positive. Patients take 300 mg and 500 mg tablets. Regardless of the form of release, the effectiveness of the drug is noted. However, almost any forum has reports of the appearance of side effects when taking this drug. This indicates that the drug should be taken under strict medical supervision, carefully monitoring the dosage.