Depakine Chronosphere 500mg #30

Depakine Chronosphere instruction

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Composition

Depakine Chronosphere has in its composition the following active substances: valproic acid, sodium valproate.
Auxiliary components of the preparation: paraffin solid, silicon dioxide colloidal water, glycerol dibehenate.

Form of issue

The medicine is produced in granules.

pharmachologic effect

Antiepileptic drug.

Pharmacodynamics and pharmacokinetics

Depakine Chronosphere is an antiepileptic drug that has a sedative as well as a central muscle relaxant effect. The active substance of the drug affects the GABA-ergic system. It increases the concentration of GABA (gamma-aminobutyric acid) in the central nervous system and activates GABA-ergic transmission.
Bioavailability of the drug in the blood for oral administration is approximately 100%. It enters the brain and cerebrospinal fluid. For the onset of therapeutic effect, the minimum concentration of the drug in the blood serum is 40-50 mg / l. At a concentration of 200 mg / l, the dosage should be reduced. The maximum content in blood plasma is approximately 7 hours.
Stable concentration in plasma is formed by the 3-4 day of use. High degree of communication with plasma proteins. The drug is mainly excreted in the urine. Eating does not affect the pharmacokinetics.

Indications for use

Adults are recommended to take Depakine Chronosphere for treatment:
    bipolar affective disorders;
    generalized epileptic seizures;
    partial epileptic seizures.
For children, the drug is prescribed for the treatment of partial and generalized epileptic seizures.
In addition, it is used as a preventive agent at high temperature to avoid the appearance of seizures, if necessary.

Contraindications

The drug should not be taken with increased sensitivity to its components, disorders in the pancreas, as well as liver failure.

Side effects

During the application of Depakine Chronosphere, there may be the following side effects:
    genetic disorders: teratogenic risk;
    from the side of the central nervous system: a tremor of extremities, drowsiness, ataxia;
    from the organs of hearing: reversible and irreversible deafness;
    from the gastrointestinal tract: pain in epigastrium, nausea, vomiting, diarrhea;
    from the skin: transitory or dose-dependent alopecia;
    from the side of the immune system: allergic reactions, angioedema, a syndrome of drug rash with eosinophilia;
    from the side of the psyche: irritability, confusion, hyperactive state, hallucinations;
    from the side of blood and lymphatic system: thrombocytopenia, agranulocytosis, reduction of fibrinogen concentration in the blood;
    on the part of the organs of vision: diplopia, nystagmus;
    on the part of the genitals: male infertility;
    from the side of metabolism: isolated and moderate hyperammonemia;
    general disorders: weight gain.
In addition, in rare cases when taking the drug are possible:
    pancytopenia;
    leukopenia;
    anemia;
    disorders of bone marrow hematopoiesis;
    pancreatitis;
    toxic epidermal necrolysis;
    Stevens-Johnson syndrome;
    erythema multiforme;
    rash;
    vasculitis;
    amenorrhea;
    dysmenorrhea;
    extrapyramidal disorders;
    dementia;
    enuresis;
    syndrome of impaired secretion of antidiuretic hormone;
    hyponatremia;
    minor peripheral edema;
    liver damage;
    changes in behavior, mood;
    feeling tired;
    psychoses;
    motor anxiety;
    depression;
    aggressiveness;
    unusual agitation;
    dysarthria.

Instructions for use Depakine Chronosphere

Instructions for Depakine Chronosphere provides for taking the drug inside while eating 2-3 times a day. It should be washed down with plenty of water. The initial dosage for adults and children weighing more than 25 kg is 5-15 mg per 1 kg of body weight per day. Gradually, it can be increased by 5-10 mg / kg per week. But the maximum dose of a drug per day should not exceed 30 mg / kg.

Overdose

Overdose of the drug is fraught with the appearance of coma, accompanied by muscle hypotension, metabolic acidosis, hyporeflexia, respiratory depression. There are cases of intracranial hypertension and convulsive seizures. In general, the symptoms of overdose may be different. At very high doses, a lethal outcome is possible.
As an emergency, they make gastric lavage, maintain an effective diuresis, and observe the functioning of the cardiovascular and respiratory systems. In some cases, the use of hemodialysis and hemoperfusion is effective.

Interaction

The active substance Depakine Chronosphere activates other psychotropic drugs with simultaneous application, so you need to adjust the dose as necessary.
In addition, Depakine Chronosphere increases the plasma concentrations of Phenobarbital, Primidon, Zidovudine with the enhancement of some of their effects, including sedative from Phenobarbital. The drug also reduces the total plasma concentrations of Phenytoin.
Valproic acid activates manifestations of the toxicity of carbamazepine and lamotrigine. Drugs should be taken together only under the strict supervision of a specialist. In addition, Depakine Chronosphere complicates the metabolism of Lamotrigine in the liver and increases the half-life of its almost 2-fold.
Valproic acid reduces the average clearance value of Felbamate and enhances the hypotensive effect of Nimodipine.
Antiepileptic drugs that induce microsomal liver enzymes reduce the content of the active component Depakine Chronosphere in plasma. The same effect is provided by Felbamate when combined with this drug.
It is not desirable to combine Meflohin and valproic acid, otherwise the likelihood of an epileptic seizure is high. Efficacy Depakine Chronosphere also decreases with simultaneous use of St. John's wort and rifampicin. Its concentration, on the contrary, increases when combined with drugs that are known to have a high degree of binding to plasma proteins. Serum concentration of the drug is also increased with cimetidine or erythromycin.
It is not recommended to combine Depakine Chronosphere with Carbapenem and Topiramate. If this can not be avoided, taking drugs should be done under the strict supervision of a doctor.
Ethanol and other potentially hepatotoxic drugs simultaneously with valproic acid increase the hepatotoxic effect of the latter. And in combination with clonazepam may increase the severity of absences status.
Myelotoxic drugs with simultaneous use with Depakine Chronosphere increase the risk of oppression of bone marrow hematopoiesis.

Storage conditions

Depakine Chronosphere should be stored in a dry warm place. The temperature should not be above 25 ° C.
Shelf life of the drug is 2 years.

Reviews about Depakine Chronosphere

Reviews about Depakine Chronosphere report on the effectiveness of the drug. This is a new form of Depakine, which is very popular. Many parents are frightened by the unusual form of the known drug, but in this case it is not worth worrying about. Children can also give this medicine. This is simply a new form for the treatment of epilepsy, which makes it easier to take the drug to small patients.
Many also note that thanks to the improved form, the Depakine Chronosphere is very comfortable to carry around.