Metadoxil tabs 500mg #30

Metadoxil user manual

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Composition

    1 tablet of the drug Metadoxil includes 500 mg of methadoxine. Additional substances: magnesium stearate, MCC.
    5 ml of solution for injection administration includes 300 mg of methadoxine. Additional substances: water, sodium metabisulphite, methyl-p-hydroxybenzoate, sodium edetate.

Form of issue

    White pills biconvex round shape with a notch on one side and the name of the medication on the other side. 10 pieces in a blister, 3 or 1 blister in a paper bundle.
    A clear, colorless solution. 5 ml of solution in a glass ampoule, 5/10 ampoules in a PVC pallet, 2/1 PVC pallet in a paper bundle.

pharmachologic effect

Hepatoprotective, detoxification, antialcoholic effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Hepatoprotective action of the drug is based on the ability to regulate the ratio of fatty unsaturated and saturated acids. This increases the stability of the liver cells to the effect of peroxide oxidation of fat molecules by toxic agents.
The detoxification effect is due to the induction of liver enzymes involved in the transformation of ethanol, which reduces its toxic effect.
Metadoxine also prevents an increase in the content of triglycerides in hepatocytes, inhibits the formation of fibronectin and collagen in them, which significantly slows down the development of cirrhosis of the liver. It improves cognitive activity and the work of short memory, stimulates neurotransmitter GABA -ergic and cholinergic systems, stops the occurrence of motor stimulation, which is provoked by ethanol.
Accelerates the withdrawal of symptoms of withdrawal symptoms, smooths his somatic and mental manifestations.
Metadoxine has an anxiolytic and nonspecific antidepressant effect.

Pharmacokinetics

After oral administration, it is actively absorbed in the intestine and has a bioavailability of 65-80%.
Response with blood proteins is 50%.
It is transformed in the liver to the active derivatives - pyrrolidone carboxylate and pyridine. The half-life is 45-55 minutes. Approximately half of the drug is excreted by the kidneys during the day, another 35-45% is excreted by the intestine within four days.

Indications for use

Indications for the use of tablets:
    liver disease, mainly alcoholic etiology, as part of complex treatment;
    chronic alcoholism.
Indications for use of the solution:
    an abstinent syndrome of alcoholic genesis;
    acute alcohol poisoning.

Contraindications

    pregnancy and lactation;
    hypersensitivity to the components of the drug.
It is recommended to use with caution the drug for Parkinson's disease in the event that Levodopa is used together, since metadoxine weakens its effect.
In the solution of the drug there is sodium metabisulphite, which can cause allergic reactions in the susceptible persons or an increase in the strength and frequency of asthma attacks in those suffering from bronchial asthma.

Side effects

It is not excluded the development of allergic reactions, the appearance of bronchospasm in persons with bronchial asthma.

Instructions for Use Metadoxil (Method and Dosage)

Metadoxil tablets, instructions for use
Tablets take 1 piece twice per day orally for 25-30 minutes before eating. If necessary, the dosage is allowed to be increased to 3 tablets per day.
The duration of therapy is usually at least 3 months.
Solution Metadoxil, instructions for use
In the treatment of acute alcohol poisoning, depending on the severity of intoxication, 300-600 mg (1-2 ampoules) of the drug intramuscularly or 300-900 mg (1-3 ampoules) of the drug are administered intravenously. With an intravenous route of administration, the desired dose of the drug is dissolved in 500 ml of saline or a solution of 5% glucose and injected for 90 minutes drip.
In the treatment of alcohol withdrawal symptoms intravenously infusion 900 mg (3 ampoules) of the drug once a day for 4-7 days, depending on the severity of the patient's condition.

Overdose

There is no evidence of an overdose of the drug.

Interaction

With simultaneous use, the drug lowers the effectiveness of Levodopa.

Storage conditions

Store in the dark at a temperature of up to 25 degrees. Keep away from children.
Shelf life - 5 years.

special instructions

Influence on ability of the patient to operate motor transport is absent.

In pregnancy and lactation

It is not recommended to use the drug in these periods.

Reviews about Metadoxil

Reviews of Metadoxil on the forums indicate a good effect of the drug in the treatment of alcoholism. With respect to the effectiveness of treatment of withdrawal symptoms, patients' assessments differ. Cases of ineffectiveness or development of side effects are rare.