Zorex caps 250mg + 10mg #10

Zorex instruction for use

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Composition

The capsules 150 mg + 7 mg and capsules 250 mg + 10 mg contain the same substances, the difference is only in the ratio.
Each capsule consists of active substances: sodium dimercaptopropanesulfonate monohydrate (150 mg in capsules 150 mg + 7 mg and 250 mg in capsules 250 mg + 10 mg, calcium pantothenate - 7 mg or 10 mg, respectively).
Also included in the formulation are excipients: 113.5 (120.2 in the second version of the capsules) mg of microcellulose, 9.1 mg (12.2 mg) of citric acid monohydrate, 29.3 mg (40.2 mg) of pregelatinized starch, 30 mg (50 mg) of magnesium hydrophosphate trihydrate, 6.1 mg (9.4 mg) of povidone, 5 mg (8 mg) of colloidal silica (aerosil).
The hard gelatin capsule consists of gelatin, titanium dioxide (E171) and azorubin dye (E122).

Form of issue

Zorex is available in capsules 150 mg + 7 mg and 250 mg + 10 mg. Capsules are packaged in contoured cell packs made of PVC film and lacquered aluminum foil, 2 or 5 pcs. Each. (250 mg + 10 mg), or 10 pcs. (150 mg + 7 mg).
Each cell contour pack of 10 pcs. (150 mg + 7 mg) and 2 pcs. (250 mg + 10 mg) are placed in a separate cardboard pack. Contoured cell packs of 5 pcs. (250 mg + 10 mg) put two in a pack of cardboard.

pharmachologic effect

Zorex renders complex-forming, hepatoprotective, detoxifying and antioxidant effects on the human body.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Zorex is a complexing drug, as well as a donor of sulfhydryl (thiol) groups. It has a detoxifying effect (including those with respect to the half-life of ethanol, heavy metals and their compounds, arsenic compounds). During clinical trials, the antioxidant and hepatoprotective effects of unithiol were revealed.
The presence of active sulfhydryl groups allows unithiol, to interact with thiol poisons, as well as the half-life of alcohol (alcohol ethanol), which are in the blood and tissues, and form compounds (complexes) with them that do not have a toxic effect on the body and are excreted in the urine.
In case of taking Zorex, unitiol enters the liver. There he builds physiologically irreversible links with acetaldehyde at high speed. This causes the excretion of alcohol, or rather, ethyl alcohol, from other organs and tissues. The drug also activates the enzyme alcohol dehydrogenase, thereby enhancing the process of oxidation of ethanol, neutralizing the toxic agents of this alcohol, which performs the enzyme system of the liver.
Calcium pantothenate, present in the Zorex preparation, has the property of enhancing the detoxification effect of unitiol. Calcium pantothenate is rapidly absorbed into the intestines, and then it is split and releases pantothenic acid. This acid takes part in carbohydrate and fat metabolism, has a stimulating effect on the formation of corticosteroids, greatly accelerates the recovery processes.

Pharmacokinetics

Suction occurs quickly enough. As a result of ingestion of one capsule, which contains 250 mg of unithiol, its maximum concentration in the blood is reached after 1.5 hours and will be equal to 90-140 mg / l. The drug is in the body on average 9-11 hours, of them in the gastrointestinal tract - 15-20 minutes.
Calcium pantothenate is well absorbed by ingestion into the intestine and after being absorbed, it liberates pantothenic acid.
The half-life of the drug lasts 7.5 ± 0.46 hours.
Approximately 60% of the drug is excreted from the body with urine, some are excreted with feces.

Indications for use

Zorex is used in the following cases:
    alcohol abstinence syndrome (used to prevent and treat the state of hangover);
    chronic alcoholism (part of the prescribed complex therapy);
    acute and chronic poisoning by organic and inorganic compounds of substances such as arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony;
    intoxications caused by the use of cardiac glycosides.

Contraindications

Zorex is contraindicated in:
    severe liver disease during the period of decompensation;
    severe kidney disease during the period of decompensation;
    age less than 18 years;
    hypersensitivity to the constituents of the drug.
The drug should be taken carefully if blood pressure is lowered.

Side effects

Side effect of the drug may be the emergence of allergic reactions, but they occur infrequently. In rare cases, there is the appearance of itching, hives, rashes on the skin, mucous membranes, edema of the mucous, genital itching, stomatitis. Very rarely there is an allergic reaction to the type of angioedema, the syndrome of Stephen-Johnson. This syndrome is manifested by a sudden increase in body temperature, malaise, spot-vesiculosis or bullous eruptions on the skin, mucous membranes of the genital organs, oral cavity, in the region of the anus).
If these symptoms occur, stop taking the medication and seek help from a doctor. A higher level of risk of developing allergic reactions is experienced by people suffering from bronchial asthma or those who have an allergy in the anamnesis.
The use of too high doses causes nausea, dizziness, tachycardia, pallor of the skin.

Instructions for use Zorex (Method and dosage)

According to instructions on Zorex, this drug is taken orally. Drink it should be 30 minutes before eating, while the capsule should not be chewed. After taking the drug, drink a small amount of water.
The dosage of the drug depends on the specific case:
    For the prevention of a hangover, drink 1 capsule (250 mg + 10 mg) of Zorex after taking alcohol in the evening before going to bed.
    In case of necessity of treatment of an alcoholic abstinent syndrome the drug is taken for 1 capsule (250 mg + 10 mg) 1 or 2 times during the day. If necessary, the daily dose can be increased to a dose of sodium dimercaptopropanesulfonate 750 mg, and the amount of intake - up to 3 times per day. The drug should be consumed from 3 days to a week, until symptoms of intoxication stop.
    In the complex in the treatment of alcoholism, one capsule (150 mg + 7 mg) of the drug should be taken 1 or 2 times a day, for 10 days.
    To treat poisoning caused by arsenic compounds or heavy metal salts, 300-1000 mg / day of the drug is prescribed (calculated using sodium dimercaptopropanesulfonate). This amount of Zorex should be taken in 2-3 sessions. Treatment is carried out for a length of time from a week to 10 days.

Overdose

Signs of an overdose appear in cases of exceeding the required dose by 10 times or more.
Symptoms, the appearance of which is possible with an overdose, include: dyspnea, the development of hyperkinesia, inhibition, lethargy, deafness, the appearance of short-term seizures.
In case of an overdose, it is necessary to wash the stomach, take activated charcoal, laxatives. Also symptomatic therapy is shown, in acute cases it is necessary to carry out oxygen therapy, recommended the introduction of dextrose.

Interaction

Sodium dimercaptopropanesulfonate has the property of restoring the previously lowered sensitivity of the organism to Nitroglycerin.
Calcium pantothenate helps increase the efficiency of cardiac glycosides, causes a decrease in the toxic effect of arsenic, aminoglycoside, antibiotic streptomycin and sulfonamides.
It is impossible to combine Zorex with drugs that contain salts of heavy metals.
It is not recommended to combine with alkalis, because in such a combination the drug quickly decomposes.

Terms of sale

Allowed to dispense without a prescription.

Storage conditions

It should be stored in a dry place, protected from light, at a temperature of no more than 25 ° C.
The place where the drug is stored should be inaccessible to children.
Shelf life - 3 years.

Children

Contraindicated use at the age of less than 18 years.

In pregnancy and lactation

Information about the use of the drug during pregnancy and during the lactation period is not present. Therefore, during pregnancy and breastfeeding, its use is prohibited.

Reviews

Reviews about Zorex are quite diverse. Most reviews about Zorex with a hangover coincide in the fact that this drug is effective, but with the tendency of the body to allergies very often there is a side effect.