Nicergoline powder 4mg #5

Nicergoline user manual

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Composition

In the composition of one ampoule of Nicergoline (lyophilizate, ie composition for the preparation of a solution intended for intramuscular injection) contains 4 mg. nicergoline (active drug compound), as well as auxiliary substances such as milk sugar (lactolose monohydrate) and tartaric acid.
One tablet contains 10 mg. active ingredient, as well as potato starch, milk sugar, magnesium basic carbonate, stearic acid, povidone and magnesium stearate.
In the shell of the tablet form of the drug, there are compounds such as basic magnesium carbonate, colloidal silicon dioxide (aerosil), sucrose, povidone, beeswax, titanium dioxide, talc and medical gelatin.

Form of issue

Nicergoline is released as a lyophilizate (powder odorless white) in glass ampoules (4 mg.), Which is packaged in PVC contoured cells and placed in cardboard packages together with a solvent for the preparation of injections (0.9% sodium chloride solution) in ampoules 5 ml each, as well as with an ampoule abrasive or ceramic scarifier.
Double-convex tablets of Nicergoline, coated with a white coating, are packaged in blisters. Typically, in one carton of the drug is 30 tablets, each containing 10 mg. active drug.

pharmachologic effect

This drug has vasodilating (ie, affects the cerebral arteries) pharmacological action, and belongs to the group of alpha-adrenergic blocking drugs.

Pharmacodynamics and pharmacokinetics

Essentially, Nicergoline is a synthetic ergot alkaloid and a derivative alpha-blocker, in the chemical formula of which you can see the remains of bromine-substituted nicotinic acid. The active substance, which is part of the drug and the derivative of ergoline, has a positive effect on the hemodynamic as well as metabolic processes occurring in the brain.
Due to the alpha1-adrenergic effect of the drug, the blood flow velocity in the lungs, limbs and brain is increased, and platelet aggregation in the blood decreases and its hemorheological parameters are improved. In addition, the drug compound has an antispasmodic and at the same time myotropic effect on the muscular membrane of the vessels, thereby increasing the permeability of glucose and leveling the effect of the ergoline ring.
The drug lowers the tone of the vessels, and also saturates the arterial bloodstream with glucose and oxygen. Nicergoline has a positive effect on blood pressure, which, when taken in patients with hypertension, can gradually be normalized. The drug improves hemorheological indices, and also reduces platelet aggregation and increases blood circulation in arteriopathy.
Bioavailability of this drug is approximately 60%, its maximum concentration of nicergoline reaches in the blood an hour and a half after the first administration of the drug. From the body, the drug is 80% excreted by the kidneys, another 20% come out with feces.

Indications for use of Nicergoline

Indications for the use of Nicergoline are:
    chronic or acute disorders of the functions of cerebral metabolic vessels, which can be caused by hypertension, atherosclerosis, embolism, thrombosis, ischemic attack, vasospasm, and vascular dementia;
    Raynaud's disease;
    violation of peripheral circulation;
    migraine;
    arteriopathy of the extremities;
    vertigo;
    endarteritis;
    angiopathy is diabetic;
    diseases of the cornea;
    diabetic retinopathy;
    Neuropathy of the optic nerve.

Contraindications

Do not use this medication:
    with hypersensitivity;
    after a heart attack;
    with hypotension;
    with bradycardia;
    with intolerance to galactose;
    during pregnancy;
    under the age of 18;
    in the period of breastfeeding;
    with glucose-galactose malabsorption;
    with a deficiency of lactose.
With special care, the drug is taken with gout, as well as with hyperuricemia and in combination with drugs that affect the excretion and metabolism of uric acid.

Side effects

In the course of treatment with Nicergoline, these side effects of the drug may occur:
    lowering blood pressure;
    nausea;
    abdominal pain;
    dizziness;
    diarrhea;
    heat;
    drowsiness;
    allergic reaction;
    insomnia;
    increased levels of uric acid.

Instructions for the use of Nicergoline (Method and dosage)

The instructions for the use of tablets of Nicergoline said that the drug should be taken three times daily before meals in a dosage equal to 5-10 mg. The duration of the course of treatment, as a rule, is 3 weeks, however, with acute medical necessity it can increase up to several months.
The lyophilizate is diluted with sodium chloride (0.9%) before application and administered intramuscularly twice a day at a dose of 2-4 mg. Dosage, as well as the duration of therapeutic treatment, depends on the nature and severity of the disease, as well as on the patient's condition.
Patients with kidney disease are advised to take the drug at the lowest dosages.

Overdose

Symptoms that signal an overdose are hypotension, orthostatic collapse, and allergic reactions. In addition, when the recommended dosage of Nicergoline exceeds the severity of side effects.

Interaction

Nicergoline increases the effectiveness of anxiolytics, hypotensive and antipsychotic drugs. Kolestyraminy, as well as antacids reduce the absorption of the drug stomach. Idiosyncrasy may occur with the simultaneous use of this drug with adrenostimulators.

Terms of sale

To buy Nicergoline you don't need a prescription.

Storage conditions

Nicergoline in tableted form is included in list B, so the drug should be stored at 25 ° C in a place protected from light and children.
The lyophilizate should be stored at a temperature not exceeding 10 ° C, in an inaccessible place for children.

Shelf life

2 years for tablets of Nicergoline and 3 years for powder-lyophilizate, intended for intramuscular injection.

special instructions

When taking the drug is prohibited to use drugs and alcohol. To avoid hypotension, especially at the beginning of the use of the drug, after intramuscular injection of Nicergoline, patients should remain for some time in a horizontal position.
When taking medication, it is worthwhile to refrain from driving vehicles and from engaging in activities associated with the need for instant psychomotor reactions and with increased concentration of attention. Elderly people need to adjust dosages depending on the level of creatine in the blood.

Children

Contraindicated to use the drug during therapeutic treatment of patients under the age of 18 years.

With alcohol

The use of alcohol during treatment with Nicergoline is prohibited.

During pregnancy (and lactation)

Lactation and pregnancy are absolute contraindications to the use of the drug.

Reviews of Nicergoline

Many patients leave negative reviews about Nicergoline, because they face its side effects and for a long time do not feel the improvements and drug effect of the drug.