Recognan solution 100mg/ml 10ml #10

Recognan user manual

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Clinico-pharmacological group: Nootropic drug
Pharmaco-therapeutic group: Nootropic agent

pharmachologic effect

Citicoline, being the precursor of the key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: it helps to restore damaged cell membranes, inhibits the action of phospholipases, preventing excessive formation of free radicals, as well as preventing cell death, affecting the mechanisms of apoptosis.
In the acute period of a stroke, reduces the volume of damaged tissue, improves cholinergic transmission.
In traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms, in addition, reduces the duration of the recovery period.
Citicoline is effective in treating cognitive, sensory, and motor neurological disorders of degenerative and vascular etiology.
In chronic cerebral ischemia, citicoline is effective in treating disorders such as memory impairment, lack of initiative, difficulties encountered in performing daily activities and self-care. Increases the level of attention and consciousness, and also reduces the manifestation of amnesia.

Pharmacokinetics

Suction

Citicoline is well absorbed when taken orally. Absorption after oral administration is almost complete, and bioavailability is approximately the same as after intravenous administration. After ingestion and parenteral administration, the concentration of choline in the blood plasma increases significantly.

Distribution

Citicoline is widely distributed in brain structures, with the rapid introduction of choline fractions into structural phospholipids and cytidine fractions - into cytidine nucleotides and nucleic acids. Citicoline penetrates the brain and actively integrates into the cellular, cytoplasmic and mitochondrial membranes, forming part of the structural phospholipid fraction.

Metabolism

When a / in and / m introduction citicoline is metabolized in the liver to form choline and cytidine.

Removal

Only 15% of the administered dose of citicoline is excreted from the human body: less than 3% by the kidneys and through the intestines, and about 12% with exhaled air.
In the excretion of citicoline in the urine can be divided into 2 phases: the first phase, which lasts about 36 hours, during which the rate of excretion rapidly decreases, and the second phase, during which the excretion rate decreases much more slowly. The same is observed in exhaled air - the rate of excretion decreases rapidly after about 15 hours, and then decreases much more slowly.

Recognan, indications for use

- acute period of ischemic stroke (as part of complex therapy);
- recovery period of ischemic and hemorrhagic strokes;
- traumatic brain injury (TBI), acute (as part of complex therapy) and the recovery period;
- cognitive and behavioral disorders in degenerative and vascular diseases of the brain.

Contraindications

- vagotonia (predominance of the parasympathetic part of the autonomic nervous system);
- rare inherited diseases associated with fructose intolerance (for oral administration);
- children's and teenage age up to 18 years (due to the lack of clinical data);
- Hypersensitivity to Recognan.
Information about the relative contraindications for the use of the drug inside is not.

Dosage and administration

Oral solution

Accepted with meals or between meals. Before use, Recognan can be diluted in a small amount of water (120 ml or 1/2 cup).
The acute period of ischemic stroke and TBI: 1000 mg (10 ml or 1 sachet) every 12 hours. The duration of treatment is at least 6 weeks.
Recovery period of ischemic and hemorrhagic strokes, recovery period of TBI, cognitive and behavioral disorders in degenerative and vascular diseases of the brain: 500-2000 mg / day (5-10 ml 1-2 times / day or 1 sachet 1-2 times / day ). The dose and duration of treatment is set depending on the severity of the symptoms of the disease.
Elderly patients dose adjustment is not required.

Instructions for use attached to the vial pipette dosing

1. Place the pipette dispensing bottle (the pipette piston is fully lowered).
2. Gently pull on the dosing pipette piston until the level of the solution is equal to the corresponding mark on the pipette.
3. Before taking the right amount of solution can be diluted in 1/2 cup of water (120 ml).
After each use, it is recommended to rinse the pipette with water dosing.

Recommendations for use of the drug Recognan in bags

1. Take a bag of Recognan 1000 mg per edge and shake.
2. Tear off the edge of the bag in the place indicated by the dotted line.
3. Drink the contents of the bag immediately after opening.
4. Or dissolve in 1/2 cup of drinking water (120 ml) and drink.

Injection

Recognan is administered in / in or in / m.
IV is prescribed in the form of a slow IV injection (within 3-5 minutes, depending on the dose prescribed) or IV drip infusion (40-60 drops / min).
In / in the route of administration is preferable to the / m. When a / in the introduction should avoid re-injection of the drug in the same place.
The acute period of ischemic stroke and TBI: 1000 mg every 12 hours from the first day after diagnosis. The duration of treatment is at least 6 weeks. 3-5 days after the start of treatment (if the function of swallowing is not impaired), it is possible to switch to the oral forms of Recognan.
The recovery period of ischemic and hemorrhagic strokes, the recovery period of TBI, cognitive and behavioral disorders in degenerative and vascular diseases of the brain: 500-2000 mg / day. The dose and duration of treatment depend on the severity of the symptoms of the disease. Perhaps the use of oral forms of the drug Recognan.
Elderly patients dose adjustment is not required.
The solution in the ampoule is intended for single use. It should be used immediately after opening the ampoule.
Recognan is compatible with all types of isotonic infusion solutions and dextrose solutions.

Use during pregnancy and lactation

Data on the use of citicoline during pregnancy is not enough. Appointment of the drug Recognan is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
In animal studies, no negative effects have been identified.
When prescribing Recognan during lactation, women should stop breastfeeding, because there are no data on the release of citicoline in human breast milk.

Side effects of Recognan

Frequency of adverse reactions: very rarely (less than 1/10 000) (including individual cases).
Allergic reactions: rash, pruritus, anaphylactic shock.
Nervous system disorders: headache, dizziness, insomnia, agitation, hallucinations. In some cases, Recognan can stimulate the parasympathetic system, as well as briefly change blood pressure.
On the part of the digestive system: nausea, vomiting, diarrhea, loss of appetite, changes in the activity of liver enzymes.
General reactions: feeling of heat, tremor, shortness of breath, numbness in paralyzed limbs, swelling.
If any of these side effects are exacerbated or any other side effects are noted, the patient should inform the doctor.

special instructions

In the solution for ingestion in the cold, a small amount of crystals may form due to temporary partial crystallization of the preservative. Upon further storage in recommended conditions, the crystals dissolve within a few months. The presence of crystals does not affect the quality of the drug.

Influence on ability to drive motor transport and control mechanisms

During the period of treatment, patients should take care when performing potentially hazardous activities that require increased attention and speed of psychomotor reactions (including driving, working with moving machinery, the work of the dispatcher, the operator).

Interaction

Citicoline enhances the effects of levodopa.
It should not be administered simultaneously with drugs containing meclofenoxate.

Overdose

Given the low toxicity of the drug, overdose cases are not described.

Shelf life

The shelf life of the oral solution in vials is 3 years, in sachets - 2 years; injection solution - 3 years. Do not use after the expiration date printed on the package.

Storage conditions

The drug should be kept out of the reach of children; oral solution - at a temperature of 15 ° to 25 ° C, solution for IV and v / m administration - at a temperature not exceeding 25 ° C.

Terms of sell

You don't need a prescription to buy Recognan.