Trileptal tabs 600mg #50

Trileptal pills instruction

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Composition

In 1 tablet of oxcarbazepine, 150 mg, 300 mg or 600 mg.
Silicon dioxide, crospovidone, hypromellose, magnesium stearate, MCC, - as auxiliary substances.
In 1 ml of the suspension of oxcarbazepine 60 mg. Sodium saccharinate, sorbic acid, propyl parahydroxybenzoate, macrogol stearate, sorbitol liquid, methyl parahydroxybenzoate, ascorbic acid, propylene glycol, cellulose, plum-lemon flavor, purified water, as auxiliary substances.

Form of issue

Tablets 150 mg, 300 mg, 600 mg.

pharmachologic effect

Antiepileptic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The mechanism of antiepileptic action is associated with the blockade of sodium channels, which react to a change in the membrane potential. This entails the stabilization of overexcited neurons, a reduction in the carrying out of pulses in the synapses, and the suppression of serial discharges. In the antiepileptic action of the drug, it is also important to increase the conductivity of K + and modulate the calcium channels, which are activated by a high potential of the neuronal membrane. There are no interactions of the active substance with brain neurotransmitters.
Effective with epileptic seizures with monotherapy and combination therapy in adults and children. In addition, Trileptal has a normotimic effect - it eliminates circular disorders of the psyche (mood swings) and prevents the development of depression.

Pharmacokinetics

When ingested well absorbed. Eating does not affect the degree of absorption. Metabolized with the formed metabolic pathway of MHP (monohydroxy derivative). 40% of IHL is associated with blood proteins. After taking the suspension at a dose of 600 mg Cmax MHP is achieved after 6 hours, and when taking the same dose in the form of tablets - after 4.5 hours. In the form of metabolites, 95% is excreted by the kidneys, 4% with feces.

Indications for use

Trileptal is used in the form of monotherapy or combination therapy in the partial form of epilepsy, generalized form of epilepsy, Jackson seizures.
Indications for use include the use of the drug to replace other antiepileptic drugs, if there is no satisfactory therapeutic effect.

Contraindications

    hypersensitivity;
    age up to 3 years (for tablets);
    lactation period;
    age up to 1 month (for suspension).

Side effects of Trileptal

Side effects that occur very often (more than 10%): dizziness, drowsiness, diplopia, headache, nausea, vomiting.
There are often (up to 10%): asthenia, fatigue, amnesia, apathy, attention deficit disorder, depression, emotional instability, nystagmus, blurred vision, tremor, constipation, abdominal pain, diarrhea, hyponatremia, acne, alopecia, rash.
Rarely observed: leukopenia, increased activity of transaminases, urticaria, angioedema.

Instructions for use Trileptal (Method and dosage)

Inside, regardless of food time.
With monotherapy for adults, 600 mg / day are prescribed in 2 divided doses. The therapeutic effect is usually noted at doses of 600-2400 mg, so the dose gradually increases once a week no more than 600 mg. In a hospital, a faster dose increase is carried out. At these dosages it is more expedient to take pills Tricoletal 600 mg.
With combined therapy, the drug is administered at 600 mg per day in 2 divided doses. According to the indications, the dose is increased by 600 mg / sutraz per week. The use of combined therapy in a dose of 2,400 mg without reducing the dose of another drug is accompanied by poor tolerance. The use of the drug in a dose above 2400 mg has not been studied.
The initial dose for children from 2 years is 8-10 mg / kg of weight in 2 divided doses (with combined therapy and monotherapy). The therapeutic effect is most often observed at a dosage of 30 mg / kg per day, so the dose is increased by 10 mg / kg per day once a week to 46 mg / kg body weight.
The drug in the form of a suspension is used in children from 1 month. Before taking the suspension, the vial should be shaken well and the required amount of the drug is measured. Dose in mls using a syringe is recruited from the vial. The package contains a 10 ml syringe for adults and 1 ml for small children. The suspension is taken directly from the syringe or diluted with water. The open vial is stored for up to 7 weeks. Suspension and tablets are interchangeable, so the instruction for the use of Trileptal contains a table of dose recalculation from mg / ml.

Overdose

Single cases of drug overdose were observed with the intake of 24000 mg.
There is pronounced drowsiness, dizziness, hyperkinesia, ataxia, nystagmus, nausea and vomiting.
There is no specific antidote. To reduce absorption, gastric lavage is performed and sorbents are assigned. Symptomatic treatment is performed.

Interaction

It should be taken into account that the active substance is an inhibitor of cytochrome CYP2C19, so the administration of large doses of this drug and Phenobarbital, phenytoin leads to interaction.
The concentration of Phenytoin increases by 40% with the co-administration of Trileptal above 1200 mg / day, and therefore, you can reduce the dose of Phenytoin. The drug increases the concentration of Phenobarbital, while Phenobarbital reduces its concentration by 30-31%.
Felbamate and Clobazam do not affect the concentration of this drug.
Valproic acid reduces the concentration by 18%.
The appointment together with hormonal contraceptives leads to a decrease in the effectiveness of contraceptives.
Strengthens the sedative effect of ethanol.
Cimetidine, Erythromycin, Warfarin, Dextropropoxyphene do not affect the parameters of IHL.
Verapamil reduces the concentration of active metabolites by 20%.

Storage conditions

At temperatures up to 300 ° C.
Shelf life - 3 years.

Reviews about Trileptal

Reviews about Trileptal on the forums indicate the effectiveness of this drug as with focal epileptic seizures, and with generalized tonic-clonic. Many patients successfully replaced, on the recommendation of a doctor, Carbamazepine, Gabapentin, Phenytoin, or Valproate for treatment with one Trileptal.
Its effectiveness was not lower, and tolerability was much better, which allowed for a long time without complications to take this drug. So, it is noted that within 12 months. treatment with this drug alone, complete disappearance of seizures in patients with generalized form of epilepsy was observed. All taking the drug note that it, in comparison with Finleptsinom and Karbamazepine, has fewer side effects.
"I finally switched from Finnlinesin to Trileptal, after receiving it my head does not hurt, and night attacks have passed. From pobochek I can complain of drowsiness. "
"Very good drug. Has passed on Trileptal 300 and all has changed - the minimal drowsiness, appetite as usually. Only positive feedback. "
"I take 1800 mg (3 times 600), transferred a year ago. In comparison with Finlepsin very vigorous state of health, on Finlepsin as a somnambulist went. "
"My daughter accepts Trileptal for six years, there are no seizures, before she took Finlepsin and had nocturnal seizures."
Of the side effects most often occur drowsiness, increased appetite, tearfulness, dizziness and dizziness in the eyes 40 minutes after taking the pill.