Tamoxifenum 20mg #30
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You can buy Tamoxifenum on this pageTamoxifen instruction manualThe drug Tamoxifenum belongs to the group of antiestrogenic agents with pronounced antitumor effect.Form of formulation and composition of the preparationThe drug Tam..
You can buy Tamoxifenum on this page
Tamoxifen instruction manual
The drug Tamoxifenum belongs to the group of antiestrogenic agents with pronounced antitumor effect.
Form of formulation and composition of the preparation
The drug Tamoxifen is available in the form of tablets for oral administration. The tablets are coated with a white or yellowish film coating and packed in 10 pieces in contour squares in a cardboard bundle with the attached detailed instructions. Each pill contains active active substance Tamoxifenum in the amount of 10 mg, 20 mg, 30 mg, 40 mg. In addition, the preparation includes a number of auxiliary substances - lactose monohydrate, povidone, microcrystalline cellulose.
Indications for use
Tablets Tamoxifenum is prescribed to patients for the treatment of the following pathologies:
breast cancer in women, associated with the amount of estrogen in the body;
breast cancer in men, developed after castration;
endometrial cancer of the uterus;
sarcoma of soft tissues in the presence of estrogen receptors in the tumor;
prostate cancer in men with no therapeutic effect on other drugs.
Before starting the use of the drug, it is necessary to carefully study the accompanying instructions, since the tablets have a number of contraindications:
pregnancy or suspected of it;
the period of breastfeeding;
individual hypersensitivity to the components of the drug.
Relative contraindications to the use of the drug are:
increased intraocular pressure;
simultaneous treatment with anticoagulants of indirect action.
Method of administration and dosage
The dose of the drug and the duration of the course of therapy is determined individually for each individual patient, which depends on the diagnosis, the severity of the clinical picture of the disease, the presence of complications.
At the initial stage of treatment appoint 20 mg of drug per day, gradually if necessary increasing the dose. Tablets are taken orally, without chewing or grinding, with a small amount of liquid.
If the symptoms do not decrease, but progress and the patient feels worse, taking pills Tamoxifenum immediately stop and go to the doctor.
Use of the drug during pregnancy and during breastfeeding
Clinical experience of the use of tablets Tamoxifenum among pregnant women is not available, therefore, it is not recommended to prescribe the drug to future mothers. It is not known how therapy can affect the intrauterine development of the baby. If you suspect a pregnancy while taking the medication, the therapy should be stopped immediately and consult a doctor.
Active active substance of the drug is excreted in breast milk and may adversely affect the baby who is breastfed. Given this information, the drug tablets should not be given to nursing mothers, and if necessary, therapy should decide whether to stop lactation.
With the use of the drug Tamoxifenum, side effects are associated with the antiestrogenic effect of tablets and are manifested as:
bleeding from the genital tract by the type of menstruation;
sensation of heat in the head and face by the type of tides;
itching of the genitals and increased vaginal discharge;
fluid retention in the body, swelling of the limbs and face;
anorexia, nausea, vomiting, stool disorders, bloating;
increased fatigue, complaints of chills, apathy, drowsiness;
rash on the skin, hives;
cataract, retinopathy, neuritis;
headaches and dizziness;
leukopenia and thrombocytopenia;
hepatitis, jaundice development severe liver damage;
development of cysts on the surface of the ovaries.
The use of tablets Tamoxifenum in women often causes a delay in menstruation, amenorrhea, changes in the endometrium, tissue hyperplasia, uterine fibroids, and in rare cases the development of endometrial cancer.
An overdose of the drug
Cases of drug overdose have not been described, however, to avoid the increase of the above described adverse reactions, it is not recommended to exceed the dose prescribed by the doctor. There are no antidotes of the drug, in case of signs of overdose, the patient is vomited, washed stomach and perform symptomatic treatment.
Interaction of the drug with other drugs
The drug Tamoxifen is not recommended to be prescribed to patients simultaneously with cytostatics, as this increases the risk of thrombosis and changes in the clinical picture of the blood.
The drug should not be combined with antacids, blockers of histamine H2 receptors, as this can provoke premature dissolution of the enteric-dissolving tablet coating and the development of side effects.
Against the background of the use of the drug Tamoxifenum, the therapeutic effect of anticoagulants of indirect action can be strengthened, which should be taken into account in this drug interaction.
The simultaneous use of a thiazide series with diuretics may increase the risk of hypercalcaemia and side effects from the kidneys.
The drug Tamoxifen is not recommended to be administered to patients simultaneously with Tegafur, since this drug interaction leads to the development of chronic hepatitis and cirrhosis of the liver.
With the simultaneous administration of Tamoxifenum tablets with other hormonal drugs, for example, estrogen-containing contraceptives, the therapeutic effect of both drugs may be weakened.
Women who undergo treatment with Tamoxifenum should regularly visit the gynecologist for an examination. In case of acyclic bleeding from the vagina, the drug should be discontinued and consult a doctor.
Patients with bone metastases should check the concentration of calcium in the blood serum from time to time against the background of drug treatment. If you find any irregularities, the drug should be stopped immediately.
Against the background of the use of tablets, the risk of developing thrombosis increases. In case of a symptom of thrombosis in the form of puffiness of the lower extremities, cyanosis of the skin of the legs, pain along the veins, treatment with the drug is stopped and consulted by the doctor.
Tablets Tamoxifenum when used in women of childbearing age can provoke ovulation, so women should use barrier means of contraception against the background of therapy and in every possible way avoid pregnancy.
During treatment with the drug, patients need to regularly monitor the blood picture, blood pressure, pulse and other important parameters.
Tamoxifenum is able to cause dizziness and drowsiness, so during treatment with the drug should refrain from driving and complex mechanisms that require increased concentration.
Keep the tablets out of the reach of children in a dark, cool place. Shelf life of the drug is 4 years from the date of manufacture, at the end of this period the drug can not be used for treatment.