Tamoxifenum tabs 20mg #100

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Composition

The composition of Tamoxifen is 15.2; 30.4 or 45.6 mg tamoxifen citrate, respectively, equivalent to 10, 20 or 30 mg tamoxifen.
Tablets are packaged in blisters, containers or polyethylene bottles at 10, 20, 30, 40, 50, 60, 90, 100, 120, 150 or 300 pcs.

Form of issue

Pills.

pharmachologic effect

Has antiestrogenic and antitumor properties.

Pharmacodynamics and pharmacokinetics

Tamoxifen is a nonsteroidal antitumor antiestrogenic drug characterized by its ability to competitively inhibit peripheral estrogen receptors in target organs and tumors originating from them.
As a result, a complex "tamoxifen-receptor-cofactor transfer" is formed, which, translocating into the nucleus of the cell, prevents hypertrophy of cells that depend on estrogen regulation.
The Sportswiki states that the substance was first synthesized in 1971 and became the first antiestrogenic agent among representatives of the class of selective estrogen receptor modulators (IMRES).
Has an antigonadotropic effect and suppresses the formation of prostaglandins in tumor tissue, slows the development of the tumor process, which is stimulated by estrogens.
After taking a single dose of the drug, the ability to block estrogens persists for several weeks.

Promotes the release of pituitary gonadotropic hormones, thereby causing ovulation in women in its absence. When oligospermia in men increases the serum concentration of estrogens, testosterone, luteotropin and follitropin.
Tamoxifen and some of its metabolites exhibit the properties of potent inhibitors (oxidases) with mixed functions (monooxygenases) of the liver cytochrome P450 system. However, the extent to which these effects are clinically significant is not known.
In some cases, Tamoxifen is effective in estrogen-independent tumors. The substance has a partial estrogen-like effect on the lipid spectrum of blood plasma, endometrium and bone tissue.
Absorption of Tamoxifen is high, the TCmax index is from 4 to 7 hours after oral administration of the tablet. Stable plasma concentration is observed 4 weeks after the start of treatment with a dosage of 40 mg / day.
With albumin of blood plasma, the substance binds to 99%. Metabolization occurs in the liver by demethylation, hydroxylation and conjugation and with the participation of the CYP2C9 isoenzyme.
Metabolites are derived mainly from the contents of the intestine and partly from the kidneys (a small amount). The withdrawal is carried out in two stages. The initial half-life of the main metabolite circulating in the systemic circulation is 7 to 14 hours, the final slow half-life is 7 days.

Indications for use

The use of tamoxifen is advisable when:
    estrogen-sensitive tumors;
    malignant damage to breast tissue (especially during menopause in women);
    breast cancer, including in men after surgical removal of the genital organs;
    protocol of breast cancer (ductal carcinoma in situ);
    endometrial cancer.
In breast cancer, the drug can also be used as a supplement to medical, surgical treatment and radiation therapy.
For men, Tamoxifen may also be prescribed for gynecomastia. However, the drug works if the pathology has developed recently and is associated with the use of anabolic steroids.

Contraindications

Tamoxifen is contraindicated when:
    hypersensitivity to the components of the drug;
    severe forms of thrombocytopenia, leukopenia and hypercalcemia;
    thromboembolism of the pulmonary artery (PE) or deep vein thrombosis, which are associated with the use of anticoagulants indirect effect of the coumarin series (in the anamnesis);
    pregnancy;
    breastfeeding.
Caution should be used to treat patients with eye diseases (including cataracts), liver and thromboembolic disease (including history), expressed thrombophlebitis, hyperlipidemia.

Side effects

The administration of tamoxifen may be accompanied by such side effects as:
    transient thrombocytopenia, leukopenia, neutropenia;
    allergic reactions (occur rarely and manifest as reactions of hypersensitivity, rarely - angioedema);
    headaches and dizziness;
    leg cramps;
    drowsiness;
    violation of taste;
    confusion of consciousness;
    visual impairment (reduction of its acuity, cataract, optic neuritis, corneal opacity, retinopathy);
    sensation of hot flush to face;
    thrombosis (the likelihood of its development increases with the simultaneous use of Tamoxifen with cytotoxic drugs);
    PE;
    pancreatitis;
    nausea and vomiting;
    constipation or diarrhea;
    serious violations of the functional state of the liver, fatty degeneration of the organ, hepatitis, cholestasis;
    rashes on the skin;
    alopecia, less often - increased hair growth;
    multiform or malignant exudative erythema;
    increased dryness of the skin;
    change in laboratory parameters (increased activity of liver enzymes, hyperlipidemia, hypertriglyceridemia, in patients with bone metastasis in the bone tissue - hypercalcemia);
    fluid retention in the body;
    carcinogenic effect;
    increased fatigue;
    anorexia;
    parapemphigus (bullous pemphigoid);
    increased body temperature;
    pain in bones and / or lesions;
    increased fatigue;
    increase in the size of soft tissue tumors (in some cases, the pathological process may be accompanied by severe erythema on the affected parts of the body and adjacent tissues;
    abnormal redness and rash, usually within 14 days);
    myasthenia gravis;
    increase in body weight.
The most common side effects of Tamoxifen in women (noted in about every tenth patient) are pathological uterine (vaginal) bleeding, menstrual irregularities, high blood flow, the appearance of whitecaps. These symptoms are due to the antiestrogenic effect of the drug.
When taking the drug in the period of premenopause, ovarian cysts can be formed (the incidence of this side effect is 0.1-1%). In rare cases, the use of tablets is accompanied by pruritus vulva and endometrial proliferation (in particular, endometrial hyperplasia and endometriosis disease).
Based on the reviews, among other side effects in men may be decreased libido and impotence.

Instructions for use of Tamoxifen (Method and dosage)

The instructions for Tamoxifen indicate that the dosing regimen is set individually, depending on the indications and the antitumor treatment scheme chosen by the physician.
With malignant damage to the tissues of the breast, the daily dose of the drug is from 20 to 40 mg. Tablets are taken once or in two doses (usually in the morning and in the evening).
The dose of Tamoxifen in endometrial cancer is 20-30 mg with a multiplicity of applications once or twice a day.
The course of treatment is long, until signs of disease progression appear. This is due to the fact that the effect of using the drug persists against the background of a constant intake of tablets.
If this is necessary, the treatment is supplemented with radiotherapy or the administration of cytotoxic drugs.
The highest dose of tamoxifen is 40 mg / day.
Tablets are swallowed without chewing, and washed down with a small amount of liquid. If a single dose is shown, it is optimal to take the necessary dose in the morning.

The use of Tamoxifen in bodybuilding

Tamoxifen in bodybuilding is used to prevent the side effects of anabolic steroids, including gynecomastia, excessive accumulation of fluid in the body, fat deposition in the cellulose, progression of atherosclerosis, dyspepsia, peripheral edema, iron deficiency anemia, liver dysfunction, jaundice, hepatonecrosis; hypocoagulation, which manifests itself as a tendency to bleed; Cholestatic hepatitis, liver cancer, hypercalcemia, and masculinization in women.
The drug is considered indispensable in PKT (post-course therapy) athletes, because it has the ability to effectively restore the indices of endogenous testosterone, which are disturbed by anabolic effects.
How to take Tamoxifen in bodybuilding? The dose of the drug is selected individually. Usually it varies from 10 to 40 mg / day. In this case, taking less than 30 mg / day, as a rule, is not accompanied by side effects.
The full course is calculated approximately on 7 packs on 30 tablets.
Before taking Tamoxifen, always consult a doctor.

How do I take Tamoxifen after a course?

The drug is taken on the second week of the steroid cycle (this is due to the fact that the estrogen level rises by the end of the first week of the cycle) and ends two to four weeks after its completion (in some cases, experts recommend continuing until the next cycle).
The effective daily dose of Tamoxifen varies from 20 to 60 mg with a multiplicity of applications 2 or 3 times a day.
To correctly calculate the necessary dose after the course of androgens and anabolic steroids, you must follow a simple rule:
    at a total dose of AAS less than 0.5 grams per week Tamoxifen is taken at 20 mg per day;
    if the dose of AAS is 0.5 to 1 gram per week - 40 mg per day;
    if the dose of AAS exceeds 1 g per week - 60 mg per day.

Tamoxifen or Proviron?

Tamoxifen and Proviron are drugs that bodybuilders are often encouraged to take in a complex to reduce the side effects associated with taking anabolic drugs and improve athlete athletic performance.
The recommended daily dose of Tamoxifen is 20-30 mg, Proviron is 25-50 mg.
Proviron is an antagonist of estrogen, and Tamoxifen is an antiestrogen. The first is aimed at suppressing the formation of estrogens and preventing the aromatization of steroids, while the latter only blocks estrogen receptors.
Thus, we can say that Proviron has the ability to eliminate the cause of aromatization, and Tamoxifen - treats its symptoms. In this regard, the men who are on the course, experts recommend choosing in favor of Proviron.
The recommendation to drink anti-estrogens after the end of the cycle is a misconception.
If an athlete is taking anabolics that are not susceptible to aromatization, there is no need for using aromatase inhibitors, while tamoxifen is included only at the final stage of the course.

Clomid or Tamoxifen?

Analyzing the characteristics of both drugs, we can conclude that the preferred option for the athlete is Tamoxifen. This is due to the following factors:
    with the same ability to restore the level of endogenous testosterone, it acts less on the pituitary than Clomid;
    Tamoxifen has an antiestrogenic effect throughout the body (including the hypothalamus and pituitary gland), which not only normalizes the secretion of testosterone, but also prevents the retention of fluid in the body;
    Tamoxifen helps lower cholesterol levels, which is relevant for people taking steroids;
    on the background of the use of Clomid, an increase in the globulin binding to testosterone, which adversely affects mass collection;
    The cost of Tamoxifen is significantly lower than the cost of Clomid.

Nolvadex or Tamoxifen?

Choosing between Nolvadex and Tamoxifen, it should be remembered that Nolvadex is one of the trade names of Tamoxifen. That is, drugs are identical in their effect on the body, have the same indications and contraindications, provoke the same side effects.

Overdose

Signs of an overdose of Tamoxifen are hyperreflexia, dizziness, tremor, unsteadiness of gait. If there is a suspicion of an overdose, stop taking the drug.
Therapy is symptomatic.

Interaction

Potentiates the effects of indirect anticoagulants. In this regard, it is required to carefully monitor the patient's condition, so that if necessary, adjust the dose of anticoagulants.
More than a third (by 37%) reduces the concentration of letrozole in the blood serum.
Cytotoxic agents increase the risk of blood clots.
In combination with tegafur can provoke cirrhosis of the liver and active chronic hepatitis. When used simultaneously with medicines containing estrogens (in particular, with estrogen-containing contraceptives), the specific effect of both agents is weakened.
Drugs that reduce the excretion of Ca2 + (including thiazide diuretics), increase the likelihood of hypercalcemia.
Simultaneous application with bromocriptine increases the concentration of Tamoxifen in the blood serum.
Drugs that reduce the acidity of gastric juice, including, including antacid and H2-antihistamines, can provoke premature dissolution and loss of protective effect of the enteric coating of the tablet. In this regard, between the reception of Tamoxifen and these medications should be maintained interval of at least 1-2 hours.

Terms of sale

Without recipe.

Storage conditions

At room temperature in a light-protected, out of the reach of children.

Shelf life

24 months.

special instructions

In the course of the experimental studies, genotoxic and mutagenic effects of Tamoxifen were revealed. During the period of drug treatment, women of reproductive age should use barrier contraceptives and other non-hormonal methods for preventing pregnancy.
Women in the premenopausal period before starting the pill should undergo a medical examination to exclude pregnancy. The patient must be informed of possible risks to the fetus if fertilization of the egg occurs during treatment with Tamoxifen or within 8 weeks after completion of the course.
In some cases, the use of the drug for the treatment of breast cancer in women during premenopause can provoke the suppression of menstruation.
Also, in the treatment with Tamoxifen, there is an increase in the incidence of changes in the endometrium, including the formation of polyps, tissue hyperplasia and the development of a cancerous tumor.
The appearance of abnormal uterine bleeding during treatment or after the end of the course of taking the drug is the reason for going to the doctor and conducting a thorough examination.
There is no reliable information about the ability of Tamoxifen to enter breast milk, so if it is necessary to use the drug, lactation should be discontinued.

In pregnancy

The use during pregnancy is contraindicated.

Reviews of Tamoxifene

Reviews about Tamoxifene in the bulk of the positive and are evidence of the high effectiveness of this drug (including in comparison with many other applied IMRES).
However, given the pharmacological profile of the facility, it would be incorrect to evaluate its effectiveness solely from the reviews. The drug is used in the treatment of serious pathologies such as cancer or hormonal disorders, so its impact on the body of each patient individually.
The main disadvantage of Tamoxifen is that it often provokes side effects, and in a number of cases it can cause the development of another, no less serious disease.
The reviews of Tamoxifen (Hexal, Ebewe, Ferein, etc.) state that patients often do not have to discuss the need for therapy with the use of these funds, since in most cases their purpose is not only about health, but also about life patient. In this regard, to judge whether a preparation is bad or good is almost impossible.

If we talk about the results of the studies, they showed that the long-term use of Tamoxifen allows one to increase the survival rates by an order of magnitude among patients who have been diagnosed with breast cancer. In this regard, the drug will be prescribed to be taken within 5 years after the diagnosis, and not within 2 years, as it was before.
With a ten-year admission, there was a decrease in the likelihood of recurrence of the disease, the death rate from the underlying disease, and the overall mortality rate among patients. However, it was found that prolonged treatment with the drug may cause endometrial cancer: in the group of women who took Tamoxifen for 10 years, it developed in 3% of cases; in the group of women who were treated with the drug for 5 years - in 1.6% of cases.
Along with feedback on the use of the drug for the treatment of malignant diseases, there are also reports on its use in bodybuilding. Analyzing them, we can conclude that fans of bodybuilding, wishing to eliminate the effects of estrogenic effects of anabolic steroids, consider Tamoxifen irreplaceable for themselves.

Experts also say that such an intrusion into one's own organism and the processes taking place in it can have a detrimental effect on health, and if not now, then in the future. Therefore, before you "appoint" yourself Tamoxifen, you should be examined by a doctor and a good weigh of the pros and cons.