Ascoril Expectorant syrup 100ml
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Ascoril Expectorant syrup instructionYou can buy Ascoril Expectorant syrup hereSee also - Ascoril tabsComposition 10 ml of syrup contain: Active substances: salbutamol (in the form of sulfate) 2..
Ascoril Expectorant syrup instruction
You can buy Ascoril Expectorant syrup here
See also - Ascoril tabs
10 ml of syrup contain:
Active substances: salbutamol (in the form of sulfate) 2 mg, bromhexine hydrochloride 4 mg, guaifenesin 100 mg, menthol 1 mg;
Excipients: flavors, sucrose, sodium benzoate, sorbitol, glycerol, propylene glycol, dye yellow sunset, purified water.
The bottle is 200 ml.
Ascoril Expectorant - bronchodilator, mucolytic, expectorant.
The combined preparation has a bronchodilator, expectorant and mucolytic effect.
Salbutamol - a bronchodilator, stimulates beta2-adrenoreceptors of bronchi, blood vessels and myometrium. Warns or eliminates spasm of the bronchi, reduces resistance in the airways, increases the vital capacity of the lungs. Causes the expansion of the coronary arteries, does not reduce blood pressure.
Bromhexine - a mucolytic agent, has an expectorant and antitussive effect. Increases the serous component of bronchial secretion; activates the cilia of the ciliated epithelium, reduces the viscosity of the sputum, increases its volume and improves withdrawal.
Guaifenesin - a mucolytic agent, reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerises acidic mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary arm of the bronchi, facilitates the removal of sputum and facilitates the transition of non-productive cough to productive.
When ingested absorption is high. Eating reduces the absorption rate, but does not affect bioavailability. Connection with plasma proteins - 10%. Penetrates through the placenta. It is subjected to presystemic metabolism in the liver and intestinal wall, it is inactivated via phenolsulfotransferase to 4-o-sulfate ether. T1 / 2 - 3.8-6 hours. It is excreted by the kidneys (69-90%), mainly in the form of an inactive phenol sulfate metabolite (60%) for 72 hours and with bile (4%). The bioavailability of orally administered salbutamol is about 50%.
When ingested almost completely (99%) is absorbed into the digestive tract within 30 minutes. Bioavailability is low (the effect of primary passage through the liver). It penetrates the placental barrier and the BBB. In the liver it is demethylated and oxidized, metabolized to pharmacologically active ambroxol. T1 / 2 - 15 hours (due to slow back diffusion from tissues). It is excreted by the kidneys. When CPN breaks the excretion of metabolites. With multiple applications can cumulate.
Absorption from the gastrointestinal tract is rapid (after 25-30 minutes after ingestion). T1 / 2 - 1 hour. Penetrates into tissues containing acidic mucopolysaccharides. Approximately 60% of the injected drug is metabolized in the liver. It is excreted by the lungs (with phlegm) and kidneys both in unchanged form and in the form of inactive metabolites.
Ascoril Expectorant, indications for use
emphysema of the lungs;
Contraindications for Ascoril Expectorant syrup
hypersensitivity to the components of the drug;
Decompensated diabetes mellitus;
hepatic or renal insufficiency;
peptic ulcer of the stomach and duodenum in the stage of exacerbation;
the period of breastfeeding.
With caution: diabetes mellitus; arterial hypertension; peptic ulcer of the stomach and duodenum in the stage of remission.
Dosing and Administration
Inside. Adults and children over 12 years old - 10 ml (2 tsp) 3 times a day.
Children under 6 years - 5 ml (1 ts.lozhka) 3 times a day, 6-12 years - 5-10 ml (1-2 ts.lokki) 3 times a day.
Application in pregnancy and lactation
During pregnancy, use of the drug is not recommended.
If it is necessary to treat the drug during lactation, breastfeeding should be discontinued.
Side effects of Ascoril Expectorant syrup
Rarely when used in high doses:
increased nervous excitability,
exacerbation of peptic ulcer of the stomach and duodenum,
it is possible to stain urine in pink,
allergic reactions (rash, hives),
Other beta2-adrenomimetic drugs and theophylline increase the effect of salbutamol and increase the likelihood of side effects.
Ascoril is not prescribed concomitantly with drugs containing codeine, and other antitussive agents, because this makes it difficult for the diluted sputum to escape.
Included in the composition of the drug Ascoril bromhexine promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.
It is not recommended to use the drug Ascoril at the same time as nonselective beta-adrenoreceptor blockers, such as propranolol.
Included in the drug Ascoril salbutamol is not recommended for patients who receive MAO inhibitors.
Diuretics and preparations of GCS increase the hypokalemic effect of salbutamol.
It is not recommended to take alkaline drink simultaneously with the Ascoril preparation.
Symptoms: increased manifestations of side effects.
Treatment: symptomatic therapy.
Store in a dark place at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
Terms of sell
To buy Ascoril Expectorant syrup you don't need a prescription.