Nasic spray 0.1+5mg/dose 10ml

Nasic instruction for use

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Composition

Xylometazoline hydrochloride, dexpanthenol, benzalkonium chloride, potassium dihydrogen phosphate, sodium dodecahydrate hydrophosphate, water is sterile.

Form of issue

Spray nasal colorless with a dispensing device in darkened glass bottles of 10 ml in a cardboard package at a dosage of 0.1 mg +5 mg / dose and 0.05 mg +5 mg / dose.

pharmachologic effect

Alpha-adrenomimetic, vasoconstrictive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Pharmacological action Nasic is determined by a set of active substances that make up the drug.
Xylometazoline - decongestant (locally vasoconstrictor), has an alfa-adrenomimetic effect, narrows the vessels of the nasal mucosa, normalizes the nasal passages and nasal breathing. The effect occurs within 2-3 minutes and lasts up to 12 hours.
Dexpanthenol is a derivative of pantothenic acid, a vitamin of group B. In the human body, dexpanthenol is converted into pantothenic acid in the process of biosynthesis, which is part of coenzyme A and takes an active part in the metabolism, synthesis of corticosteroids, porphyrins and acetylation. Dexpanthenol normalizes cellular metabolism, stimulates regeneration of mucous membranes and skin, improves the strength of collagen fibers. Has a mild anti-inflammatory effect.

Pharmacokinetics

Xylometazoline is not absorbed in the body with topical application, the concentration in the blood is extremely small and it is almost impossible to determine them by modern methods.
Dextpanthenol is rapidly absorbed by the skin and biosynthesized into pantothenic acid. In the blood, it binds to albumin and beta-globulin. Its concentration in the blood is 0.5-1 mg / l. Pantothenic acid is not metabolized and is excreted through the kidneys unchanged.

Indications for use

In the treatment of acute respiratory disease, with pronounced rhinitis, acute allergic and vasomotor rhinitis, otitis media, sinusitis, to improve nasal breathing, with rhinoscopy.

Contraindications

High sensitivity to the drug, atrophic rhinitis, arterial hypertension, atherosclerosis, prostatic hyperplasia, tachycardia, porphyria, glaucoma, hyperthyroidism, age to 6 years, lactation and pregnancy. Use with caution in patients with diabetes mellitus, glaucoma, hypertension and pheochromocytoma.

Side effects

They are extremely rare and are manifested by headache, fatigue, insomnia, tachycardia, increased blood pressure, increased symptoms of congestion and irritation of the nasal mucosa.

Nasic, instructions for use (Method and dosage)

Spray Nasic is administered intranasally 3-4 times a day, one injection into the nasal passage. Before the administration of the drug, it is necessary to thoroughly clean the nasal passages. When injecting, you need to take a small breath in the nose, while the bottle should be kept in a vertical position. The duration of use of the drug Nasic 3-5 days. Before applying the spray, it is necessary to pour on the dispenser until uniform spraying occurs. Children over 6 years of age are prescribed Nasic for children, which is administered similarly. Children's Nasic is less dosed (0.05 mg + 5 mg / dose).

Overdose

An overdose of the drug is manifested by the following symptoms: convulsions, mydriasis, cyanosis, nausea, vomiting, bradycardia, vascular insufficiency, drowsiness, tachycardia, cardiac rhythm disturbance, hypertension, decreased body temperature.

Interaction

When combined with antidepressants of the tricyclic series and MAO inhibitors, there is a risk of increasing the systemic effect.

Terms of sale

You can buy Nasic without a prescription.

Storage conditions

At temperatures up to 25 ° C.
Shelf life - 3 years.

Reviews of Nasic

Reviews about the drug Nasic in most patients are favorable.
     "... Practically since childhood I suffer from allergic rhinitis. I tried many drugs. Recently, the doctor recommended Nasic. The use of Nasic for a week allowed me to breathe normally with the nose, while I noticed that Nasic drops last for 4-5 hours, and a week later the discharge from the nose practically disappeared. "
     "... A good drug! It works gently. "