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Rimantadine Actitab instruction for use

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pharmachologic effect

Rimantadine Aktivit - antiviral agent. Prevention and early treatment of influenza in adults and children over 7 years of age, prevention of influenza during the period of epidemics in adults, prevention of tick-borne encephalitis of viral etiology.

Indications

Rimantadine Actitab, indications for use
Early treatment and prevention of influenza A in adults and children over 7 years old.

Contraindications

Acute liver diseases, acute and chronic kidney diseases, thyrotoxicosis, pregnancy, children under 7 years old, hypersensitivity to rimantadine.

Dosage and administration

Inside (after eating), drinking water, according to the following scheme:
Adults are prescribed on the first day of the disease 100 mg 3 times; on the second and third days, you can take 100 mg 2 times; on the fourth day 100 mg once. On the first day of the disease, it is possible to use Rimantadine Actitab once at a dose of 300 mg.
Children from 7 to 10 years prescribed 50 mg 2 times a day; 11-14 years 50 mg 3 times a day. Treatment of influenza A should begin within 24-48 hours after the onset of symptoms and continue for 5-7 days. The optimal duration has not been established.
For the prevention of influenza in adults prescribed 50 mg 1 time per day for 10-15 days, depending on the site of infection.
For the treatment of influenza in patients with chronic renal failure (KK less than 10 ml / min), severe liver failure, elderly patients in nursing homes - 100 mg 1 time per day.

Side effects of Rimantadine Actitab

On the part of the digestive system: epigastric pain, flatulence, increased bilirubin in the blood, dry mouth, anorexia, nausea, vomiting, gastralgia.
From the side of the central nervous system: headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety, irritability, fatigue.
Other: allergic reactions.

special instructions

Compared with amantadine, it has a higher clinical efficacy and less toxic.
Perhaps the emergence of drug-resistant viruses.
With influenza B virus, rimantadine has an anti-toxic effect.
When using rimantadine may exacerbate chronic comorbidities. Elderly patients with arterial hypertension increase the risk of hemorrhagic stroke. With instructions in the history of epilepsy and ongoing anticonvulsant therapy against the background of the use of rimantadine increases the risk of developing an epileptic seizure. In such cases, rimantadine is used at a dose of 0.1 g per day simultaneously with anticonvulsant therapy.
Prophylactic administration is effective in contacts with patients (taking Rimantadine Actitab is necessary for at least 10 days after contact), with the infection spreading in closed collectives and at high risk of developing a disease during a flu epidemic.
During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Interaction

With simultaneous use of rimantadine reduces the effectiveness of anti-epileptic drugs.
Adsorbents, binders and coating agents reduce the absorption of rimantadine.
Means, acidifying urine (ammonium chloride, ascorbic acid), reduce the effectiveness of rimantadine (due to increased kidney removal).
Means alkalinizing urine (acetazolamide, sodium bicarbonate) enhance its effectiveness (reduced excretion by the kidneys).
Paracetamol and acetylsalicylic acid reduce rimantadine Cmax by 11%.
Cimetidine reduces the clearance of rimantadine by 18%.

Terms of sell

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