Tyzine Expert spray 0.1% 10ml

Tyzine Expert user manual

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pharmachologic effect

Pharmacological group: anticonvulsant - vasoconstrictor.
ATX Code: R01AA07

Pharmacodynamics

Xylometazoline (imidazole derivative) - alpha-adrenostimulator, narrows the blood vessels of the mucous membrane of the nasal cavity, eliminating the edema and hyperemia of the mucosa. Relieves nasal breathing in rhinitis.
Hyaluronic acid, which is part of the preparation, has a moisturizing effect when used in nasal medicines due to its ability to maintain mucous membranes in a moistened state and creates optimal conditions for reconstructive processes.
The action usually begins within 5-10 minutes.

Pharmacokinetics

With topical application is practically not absorbed, plasma concentrations are so small that they can not be determined by modern analytical methods.
In humans, pharmacokinetic studies have not been conducted.

Indications for Tyzine Expert

- Reduction of swelling of the mucous membrane of the nasal cavity in rhinitis, incl. allergic rhinitis, acute respiratory disease with symptoms of rhinitis, hay fever;
- alleviation of discharge from the nose with paranasal sinusitis and inflammation of the middle ear caused by a cold;
- preparation of patients for diagnostic manipulations in the nasal passages.
Spray nasal dosed 0.1% is for adults and children over 6 years.

Contraindications for Tyzine Expert

- Atrophic rhinitis;
- thyrotoxicosis;
- severe cardiovascular diseases (eg, ischemic heart disease, angina pectoris, tachycardia, arterial hypertension, severe atherosclerosis);
- increased intraocular pressure, especially occlusive glaucoma;
- condition after transsphenoidal hypophysectomy;
- surgical interventions on the meninges in the anamnesis;
- patients receiving MAO inhibitors or other drugs that can cause an increase in blood pressure;
- newborns and children under 2 years of age (for nasal spray dosed 0.05%);
- children under 6 years of age (for a nasal dosed 0.1% spray);
- Hypersensitivity to any of the components of Tyzine Expert.

Carefully

In the following cases, Tyzine Expert can be used only after carefully weighing the benefit and risk of treatment:
- hypersensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure;
- pheochromocytoma;
- endocrine diseases (eg, hyperthyroidism, diabetes mellitus);
- hyperplasia of the prostate;
- porphyria.

Application in pregnancy and lactation

Xylometazoline should not be used during pregnancy; Effects on the fetus in clinical studies have not been studied.
Tyzine Expert should not be used during breastfeeding. it is not known whether the active substance is excreted in breast milk.

special instructions for Tyzine Expert

Long-term use (more than 7 days) and an overdose of sympathomimetics, which have a decongestive effect, can lead to reactive hyperemia of the nasal mucosa. As a result, there is difficulty in nasal breathing, which leads to the fact that the patient begins to use Tyzine Expert repeatedly or even constantly. This can lead to chronic swelling (medicamentous rhinitis), and eventually even to the atrophy of the mucous membrane of the nose (the lake). It is not recommended to apply the drug in continuous mode for more than 7 days.
In more mild cases, in order to improve the patient's condition, one can first stop the introduction of sympathomimetics into one nasal passage, and after reducing complaints continue to inject it into the other nasal passage to partially provide nasal breathing.
Do not exceed the recommended dose, especially in children and elderly patients.
If the medicine has become unusable or has expired, do not throw it into sewage or into the street. It is necessary to place Tyzine Expert in a bag and put it in a garbage container. These measures will help protect the environment.

Impact on the ability to drive vehicles and manage mechanisms

With prolonged treatment or use of the drug in higher doses, one can not exclude the possibility of its systemic action on the cardiovascular system. In such cases, the ability to drive and control technology can be violated.

Composition of Tyzine Expert

In 1 ml of solution contains:
active substance: xylometazoline hydrochloride 1 mg (0.1%); the amount of the active ingredient in a single dose of 0.14 mg of xylometazoline hydrochloride;
auxiliary substances: glycerol - 8.5 mg, sorbitol - 5 mg, sodium dihydrogen phosphate dihydrate - 4 mg, sodium chloride - 3 mg, sodium phosphate dihydrate - 0.628 mg, sodium hyaluronate - 0.2 mg, water for injection - up to 1 ml .

Dosing and Administration

Adults and children over 6 years of age are prescribed nasal dosed 0.1% nasal spray at 1 dose per each nasal passage up to 3 times / day. The dose depends on the individual sensitivity of the patient and the clinical effect.
Children aged 2-6 years are prescribed a nasal spray dosed with 0.05% 1 dose per each nasal passage 1-2 times / day.
Do not use Tyzine Expert for more than 5-7 days, unless the doctor has recommended a different duration of treatment. After completion of therapy, the drug can be re-administered only after a few days.
In chronic rhinitis, Tyzine Expert can be used only under the supervision of a doctor, given the risk of atrophy of the nasal mucosa.

Method of application

Remove the protective cap. Before the first use, press the spray nozzle several times until a uniform cloud of "fog" appears. The bottle is ready for further use.
Press once to apply. The drug is inhaled through the nose. If possible, keep the spray bottle vertically. Do not spray horizontally or downward. After use, close the bottle with a cap.

Side effects of Tyzine Expert

On the part of the respiratory system: a transient mild irritation of the nose (burning) in susceptible people, sneezing. Often (> 1%,
From the nervous system: rarely (> 0.01%, headache, insomnia, visual impairment, fatigue and depression (with prolonged use in high doses).
From the side of the cardiovascular system: in isolated cases (0.1%,

Drug Interactions

Simultaneous use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants may lead to an increase in blood pressure due to the cardiovascular effects of these substances.

Overdose

Symptoms

Overdosing or accidental ingestion of Tyzine Expert inside can lead to the following symptoms: pupil dilating, nausea, vomiting, cyanosis, fever, convulsions, tachycardia, arrhythmia, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders. In addition, the following symptoms can be observed: suppression of the central nervous system, accompanied by drowsiness, lower body temperature, bradycardia, hypotension, apnea and coma.

Treatment

The use of activated carbon, gastric lavage, artificial respiration with the introduction of oxygen. To reduce blood pressure apply phentolamine 5 mg in physiological solution intravenously slowly or 100 mg orally.
Vasopressor agents are contraindicated. If necessary, antipyretic and anticonvulsant drugs are used.

Storage conditions

The drug should be stored out of reach of children at a temperature of no higher than 25 ° C.
Shelf life - 2 years.

Terms of sell

You don't need a prescription to buy Tyzine Expert.