Efferalgan tabs 500mg #16

Instruction for Efferalgan

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Composition

Efferalgan contains effervescent paracetamol as an effective ingredient as well as additional components: anhydrous citric acid, sodium hydrogencarbonate, anhydrous sodium carbonate, povidone, sodium docusate, sodium saccharinate, sodium benzoate.
Syrup Effalergan contains active ingredient paracetamol, as well as additional components: sugar syrup, macrogol 6000, citric acid, sodium saccharinate, flavor, purified water.
Efferalgan Suppositories in the composition contain the active substance paracetamol, as well as semi-synthetic glycerides as additional components.

Form of issue

    Effervescent tablets - have white color, round flat shape, edges oblique, on the one hand risk. During the dissolution of the tablet in water, active release of gas bubbles occurs. Contained in strips of 4 pcs.
    Children Efferalgan produced in the form of a syrup - viscous solution, which has a tan color, with a caramel-vanilla flavor. Packed in bottles of 90 ml, a cardboard box and a measuring spoon is inserted.
    Rectal suppositories - white, glossy, smooth, contained in blisters of 10 pieces.

pharmachologic effect

The Efferalgan UVA has an antipyretic, analgesic, weak anti-inflammatory effect on the body. Its mechanism of action is associated with the process of inhibiting the synthesis of prostaglandins. It has a predominant effect on the center of thermoregulation in the hypothalamus.
Cell peroxidases neutralize the effect of paracetamol on COX in inflamed tissues, as a result, the anti-inflammatory effect is very poorly expressed.
There was no negative effect on the processes of water-salt metabolism, as well as on the state of the mucosa of the digestive tract, because there was no effect on the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics and pharmacodynamics

After Efferalgan has been ingested, paracetamol is rapidly absorbed from the digestive tract, mainly in the small intestine by passive transport. After taking a single dose of 500 mg, the highest concentration in the blood plasma is observed after 10-60 minutes. In tissues and in liquids it is distributed well, except for cerebrospinal fluid and adipose tissue. With protein binds less than 10%, with an overdose, this relationship is slightly increased.
Metabolism occurs mainly in the liver. The half-life is 1-3 hours. In patients with cirrhosis of the liver, the elimination half-life increases. Kidney clearance is 5%. It is mainly excreted through the kidneys in the form of glucuronide and sulfate conjugates. In the unchanged form, less than 5% is output.

Indications for use

Effervescent tablets are used in the manifestation of a painful syndrome of moderate or mild:
    with headache and toothache;
    with migraine;
    in the case of pain in the lower back and in the muscles;
    with pain due to burns, injuries;
    with algodismenorea;
    in case of increased body temperature due to colds and other infectious-inflammatory diseases.
Syrup Efferalgan is intended for the treatment of children aged 1 month to 12 years (respectively, with a weight of 4 kg to 32 kg). It is used in such cases:
    as an antipyretic drug for colds, acute respiratory infections, influenza, infectious diseases, reactions after vaccine administration and other conditions in which there is an increase in body temperature;
    as an anesthetic for the manifestation of mild or moderate pain syndrome (headache, toothache, neuralgia, muscle pain, pain in burns, injuries).
Suppositories are used for pain syndrome of different origin, under the condition of manifestation of mild and moderate pains, as well as in the manifestation of fever in patients with infectious and inflammatory diseases.

Contraindications

Efferalgan tablets are contraindicated in such cases:
    with chronic alcoholism;
    people with a deficiency of glucose-6-phosphate dehydrogenase;
    in the first and third trimester of pregnancy, as well as during lactation;
    at the age of a patient under 15 years of age 9 provided that the body weight of a person is less than 50 kg);
    high sensitivity to the components of the remedy.
Carefully apply this remedy for the treatment of patients with renal or hepatic insufficiency, with congenital hyperbilirubinemia, alcoholic liver damage, viral hepatitis. Also, care must be taken when treating people in old age.
Syrup and Suppositories Efferalgan do not use:
    at the age of a child up to 1 month;
    at a high sensitivity to the components of the agent;
    with hepatic and renal insufficiency;
    in case of blood diseases;
    with a deficiency of glucose-6-phosphate dehydrogenase.
With care, the syrup is prescribed to patients with diabetes mellitus. Suppositories are not used for children suffering from diarrhea.

Side effects

When treating this drug, some side effects may develop:
    manifestations of allergies: itching, skin rash, Quincke's edema;
    hematopoiesis: thrombocytopenia, anemia, methemoglobinemia - in rare cases;
    digestive system: diarrhea, nausea, abdominal pain, vomiting, when used for a long time can develop a hepatotoxic effect;
    other manifestations: violations of kidney and liver function - in case of prolonged intake of large doses of the drug.
The doses indicated in the instructions are usually well tolerated.

Instructions for the use of Efferalgan (Method and dosage)

Efferalgan effervescent tablets, instructions for use
Tablets should be taken orally, first having dissolved one tablet in 200 ml. water. Take, according to the instructions, you need 1-2 tablets two to three times a day, with the interval should be at least four hours. The permissible dose per day is 8 tablets of Efferalgan UPSA.
People with impaired renal or hepatic function, as well as elderly patients, need to reduce the daily dose of the drug, increasing the time between taking the tablets to 8 hours. You can take the medicine for five days, provided that the tablets are used as an anesthetic, and for three days as an antipyretic.

Instructions for syrup for children Efferalgan

Using the Efferalgan baby syrup, instructions for use by parents must be observed very carefully. When determining the single dose of the drug, you need to take into account the body weight of the child: the average dose is determined from the calculation of 10-15 mg per 1 kg of the child's weight 3-4 times a day, with the largest daily dose should not exceed 60 mg per 1 kg of the baby's weight.
It is necessary to maintain the interval between doses in 4-6 hours. It is most convenient to determine the required dose with a measuring spoon, which is attached to the vial of the medicine. If the child is diagnosed with impaired renal function, the interval between doses should be increased to 8 hours.
You can use the syrup in both undiluted form and with diluted liquid milk, juice, etc.
Use the remedy for three days - to reduce body temperature and 5 days - as an analgesic. If it is necessary to continue the duration of treatment, it is important to consult a doctor.

Instructions for Suppositories

Instruction for the Efferalgan Suppositories for children provides for the rectal administration of suppositories. Suppositories 150 mg and 80 mg are used. Adult people and adolescents weighing more than 60 kg are given a single dose of 500 mg, the drug can be taken no more than 4 times a day. You can regularly use Suppositories for 5-7 days. The maximum daily dose is not more than 4 g of the drug.
Children from 6 to 12 years should use a single dose of 250-500 mg, children from 1 to 5 years - 120-250 mg, children from 3 months to 1 year - 60-120 mg. Children up to 3 months should use children's Suppositories at a rate of 10 mg per 1 kg of the child's weight. In a day, Suppositories can be applied no more than 4 times, treatment can last no more than 3 days.

Overdose

If the drug is overdosed, the patient may experience nausea and vomiting, blanching of the skin, anorexia, hepatonecrosis. If an adult has taken a dose of paracetamol more than 10-15 g, its toxic effect may appear. In particular, the activity of hepatic transaminases increases, prothrombin time increases. After 1-6 it may manifest liver damage. In rare cases, with an overdose, fulminant development of hepatic insufficiency was noted, in which the development of renal insufficiency is possible as complications.
In case of an overdose in the first six hours, you need to wash the stomach. After this, 8-9 hours after an overdose, donators SH-groups and precursors of the synthesis of glutathione - methionine, after 12 hours - N-acetylcysteine ​​should be introduced.
Further actions are determined by the level of paracetamol in the blood and by how long it took after taking it.

Interaction

Generation of hydroxylated active metabolites of paracetamol increases with the simultaneous administration of inducers of microsomal oxidation in the liver (ethanol, phenytoin, barbiturates, phenylbutazone, rifampicin, tricyclic antidepressants), and as a consequence, severe intoxication can develop.
With the simultaneous administration of ethanol and paracetamol, acute pancreatitis can develop.
Simultaneous application of inhibitors of microsomal oxidation reduces the likelihood of hepatotoxic effects of paracetamol.
The effect of uricosuric medicines decreases with the use of paracetamol.
The use of paracetamol simultaneously with salicylates significantly increases the likelihood of nephrotoxic effects.
The half-life of paracetamol increases with the simultaneous administration of salicylamide.
When taking concomitantly with chloramphenicol, the toxicity of the latter increases.
The administration of probenecid almost halves the clearance of paracetamol due to inhibition of binding to glucuronic acid.
Increases the effect of anticoagulants of indirect action when taking paracetamol.
Absorption of paracetamol may decrease with simultaneous administration of anticholinergic drugs.
If paracetamol is taken concomitantly with oral contraception, the process of excretion of paracetamol from the body is accelerated, and its analgesic effect is reduced.
The intake of activated carbon lowers the bioavailability of paracetamol.
The use of paracetamol and diazepam leads to a decrease in the excretion of diazepam.
With simultaneous use, the myelodepressant effect of zidovudine may be enhanced. There is evidence of severe toxic damage to the liver with this combination. There is also information about toxic liver damage with concurrent administration of paracetamol and isoniazid.
There are data on cases of hepatotoxicity with simultaneous administration of paracetamol and Phenobarbital.
When used concomitantly with metoclopramide, paracetamol absorption may increase and its blood level increase.
Absorption of paracetamol from the intestine increases with simultaneous administration with ethinyl estradiol.
If the patient takes the drug colestramine for less than 1 hour after taking paracetamol, the absorption of the latter may decrease.
When applied simultaneously with lamotrigine, the excretion of the latter from the body can increase.

Terms of sale

You can buy Efferalgan without a prescription.

Storage conditions

Store all forms of Efferalgan preparation at a temperature of no more than 30 degrees, in a dry place. Keep away from children.
Shelf life - 3 years.

special instructions

If the pain continues to disturb for more than 5 days while taking Efferalgan, and the fever is more than 3 days, you should consult a specialist.
When determining the content of uric acid in the blood plasma, the results of laboratory tests may be distorted.
To prevent the appearance of toxic effects, do not take paracetamol to people who regularly consume alcoholic beverages. The likelihood of liver damage increases in people with alcoholic hepatosis.
Provided that the drug is taken for a long time, it is important to monitor the liver and the picture of the peripheral blood.
Efferalgan tablets contain 412.4 mg of sodium (in 1 table), this should be taken into account for people who observe a strict low-salt diet. Also, tablets should not be taken to patients with low absorption of glucose and galactose, intolerance to fructose, a lack of isomaltase, since they contain sorbitol.
You can not take Efferalgan at the same time as other medicines that contain paracetamol. To not exceed the daily dose.
Parents or persons who care for the child should be aware of the need to cancel the medicine and contact the doctor, subject to side effects.

Efferalgan for children

Tablets effervescent should not be taken to children until the age of 15 years.
EFFERALGAN Suppositories for children and syrup for children can be taken to children aged 1 month if there is evidence of taking the medication. In this case, you need to take into account the weight of the child's body and clearly follow the instructions.

In pregnancy and lactation

Paracetamol passes through the placental barrier and is excreted in breast milk.
When pregnancy is contraindicated taking all forms of medicine in the first, as well as in the third trimester. Do not use this medication during breastfeeding. Admission to these periods is possible only under the condition of clear control of the doctor and in the presence of strict indications.

Reviews

Leaving feedback on the child's Efferalgan, parents write that the drug very quickly normalizes body temperature in the period of cold and other diseases. Users note the convenience of using a syrup, which includes a measuring spoon, as well as suppositories that are easy to inject rectally. The syrup has a pleasant taste, which facilitates its use for the youngest children.
Suppositories for children are not less effective and are often used if the child refuses to take the medicine orally. Effervescent tablets, according to the reviews, are an effective analgesic for adults, and they quickly relieve the symptoms of fever.