Panadol suppositories 250mg #10

Panadol suppositories instruction for use

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It has an analgesic and antipyretic effect. The introduction of Suppositories rectally promotes the absorption of up to 88% of the active element. Lowering the body's temperature is due to heat transfer. If the temperature is normal, then there is no reduction. Anti-inflammatory efficacy is minimal.

Form of issue and composition

For rectal use, the manufacturer has produced suppositories with the main active ingredient paracetamol. Each candle can contain it 125 or 250 mg. The color of the suppository can vary from completely white to almost white. Their shape is conical, the structure has no visible defects on the surface, homogeneous, fatty. Inclusions are absent. The auxiliary substance represented by solid fat is indicated.
Suppositories are placed in plastic cell blisters for 5 pieces. In the secondary cardboard box there are 2 blisters with a candle dosing of 250 or 125 mg and 1 official instruction.

Indications for use

In the children's age group from half a year to 2.5 years, suppositories with a dosage of 125 mg are used to lower temperature indices during the period of colds, influenza, infectious diseases and after vaccination. With the purpose of anesthesia can be used with pain in the throat, ears, teeth and with teething.
Indications are also the presence of myalgia, burn / traumatic pain, algodismenorea, neuralgia (in most cases for other dosages of Panadol suppositories).

Contraindications for Panadol suppositories

It is not prescribed for hypersensitivity to any element indicated by the official instruction in the composition; with blood diseases, functional hepatic / renal disorders in severe manifestations, inflammatory processes or bleeding in the rectum, with the genetic absence of fermentaglucose-6-phosphate dehydrogenase, chronic alcoholism and in children up to the age of 6 months.

Dosing and Administration

When administered rectally, a single dose for children aged between 1 and 5 years is 125 to 250 mg; from 6 to 12 years of age - from 250 to 500 mg. The maximum allowed number of applications in 24 hours is 4 times with interruptions between candle inserts for at least 4 hours.
In order to put a candle to your child, you should first wash your hands thoroughly with soap. Then the candle is taken out from the blister and injected into the anus. It is advisable to perform an injection after an enema (cleansing) or a natural defecation process. You can put the child on its side and pull one leg to the stomach.
Dosage is calculated by the principle of 10-15 mg / kg 3 to 4 times in 24 hours (with interruptions of 4-6 hours). The daily dosage (maximum) is not more than 60 mg / kg.
For children weighing between 8 and 12.5 kg, 1 candle is administered 125 mg every 3 to 4 times in 24 hours.
With a view to lowering the temperature, do not apply for longer than 3 days. To eliminate pain, it is acceptable to use the remedy for no more than 5 days.
Treatment is suspended in the absence of efficacy and additional medical advice is provided.
Observation of blood levels and liver function is required for therapy with Panadol suppositories for more than 1 week.

Side effects of Panadol suppositories

Probable is a variety of allergic symptoms in the form of Quincke edema, skin rash / itching. Also, cases of vomiting, changes in biochemical parameters of blood, nausea, dyspepsia are recorded. When used for a long period of time, especially at elevated dosages, there is a risk of hepatotoxic exposure.

special instructions for Panadol suppositories

Interaction:
    inducers of microsomal hepatic enzymes or substances with a hepatotoxic effect: increased hepatotoxicity of paracetamol;
    anticoagulants: increased prothrombin time;
    anticholinergic substances: decrease in the absorption process of paracetamol;
    oral contraceptives: decreased analgesic effect;
    uricosuric substances: a decrease in their effective action;
    activated carbon: a decrease in the bioavailability of paracetamol;
    diazepam: decreased excretion;
    zidovudine: increased mielodepressivnoy efficiency. The case of toxic liver damage in severe manifestations;
    isoniazid: toxic effects of paracetamol;
    phenytoin, carbamazepine, primidon, phenobarbital: a decrease in the effectiveness of paracetamol;
    phenobarbital: hepatotoxicity;
    colestyramine: reduced absorption of paracetamol;
    lamotrigine: increasing its excretion;
    metoclopramide: increased absorption of paracetamol;
    probenecid: reduced paracetamol clearance;
    sulfinpyrazone, rifampicin: increased paracetamol clearance;
    ethinyl estradiol: an increase in the absorption of paracetamol from the intestine.
Lactation period and gestation: preliminary the "benefit-risk" ratio is carefully estimated. Penetrates the milk of nursing women. The negative effect on the human fetus is not recorded.
Caution is prescribed in the Gilbert syndrome, with impaired renal / liver function, benign hyperbilirubinemia, in the elderly.
Control of blood counts and liver function is performed with long courses.
Used with the therapeutic purpose of premenstrual tension syndrome in combination with pamabrom and mepyramine.
When diarrhea occurs, the Suppositories are not applied.
In parallel with other medications containing paracetamol, do not use.
If it is necessary to analyze the blood sugar level or determine uric acid, you must first inform the doctor about treatment with Panadol.
Overdose may indicate the occurrence of vomiting, pain in the gastrointestinal tract - organs, sweating, pallor of the skin. Then there are symptoms of liver damage. Possible coma, insufficiency of the liver, encephalopathy are considered. For medical consultation, the use of Panadol suppositories is immediately stopped. The antidote is acetylcysteine.
In case of an accidental overdose, it is important to all to consult the doctor, despite the patient's good condition.
Use in pediatrics according to the dosing regimen specified in the official instruction.

Terms of sell

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Terms and conditions of storage

For storage, places that are inaccessible to children are selected with temperatures not exceeding 25 degrees. It is allowed to carry out the storage process for a period of 5 years, but not longer than the date indicated on the secondary box of cardboard and on the blister with Suppositories. Avoid exposure to sunlight.