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Flamadex user manual

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Indications for use

Pain syndrome of mild and moderate intensity with the following diseases and conditions: acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis); dysmenorrhea; toothache.

Active substance, group

dexketoprofen trometamol, NSAIDs

Dosage form

Tablets, film-coated

Contraindications of Flamadex

Stomach ulcer and duodenal ulcer, gastrointestinal bleeding, active bleeding of various genesis, increased bleeding, anticoagulant therapy, Crohn's disease, ulcerative colitis, bronchial asthma (including history), severe heart failure, renal insufficiency, hepatic insufficiency, pregnancy, lactation, hypersensitivity to dexketoprofen or other NSAIDs.

Dosing and Administration (Instruction):

Flamadex taken internally. The average recommended single dose is 12.5 mg - 1-6 times / day every 4-6 hours as needed or 25 mg 1-3 times / day every 8 hours.
The maximum daily dose is 75 mg. Duration of application - no more than 3-5 days.
For patients with impaired liver or kidney function, elderly patients, the initial dose is not more than 50 mg / day.

Pharmachologic effect

NSAIDs. Has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action is based on inhibition of the synthesis of prostaglandins due to COX suppression.
The analgesic effect occurs 30 minutes after taking, the duration of the action is 4-6 hours.

Side effects

On the part of the digestive system: heartburn, abdominal pain; rarely - erosive-ulcerative lesions of the gastrointestinal tract.
From the nervous system: headaches, dizziness, nervousness, sleep disturbance, paresthesia.
From the cardiovascular system: palpitation, increased blood pressure.
Allergic reactions: skin rash, bronchospasm.
Other: chills, swelling of the extremities, photosensitivity; rarely - a change in the pattern of peripheral blood, impaired renal function.

Special instructions

Care should be taken when prescribing the drug to elderly patients, patients with allergic reactions, systemic connective tissue diseases and patients with hematopoiesis.
Patients should be informed that if side effects occur, and if there is no clinical effect within 3-5 days of treatment, it is necessary to inform the attending physician about it.
Special care is required when using Flamadex with the simultaneous use of dexketoprofen with phenytoin, sulfonamides and drugs that reduce blood clotting.
Impact on the ability to drive vehicles and manage mechanisms
Since dexketoprofen can cause a decrease in the ability to concentrate, it should be used with caution in patients engaged in potentially dangerous activities requiring increased attention and speed of psychomotor reactions.

Interaction

Flamadex with simultaneous use of dexketoprofen with other NSAIDs, an increased risk of side effects may occur.
With simultaneous use with lithium preparations, an increase in the concentration of the latter in the blood plasma is possible.
Be wary of using dexketoprofen in less than 24 hours before or after the end of methotrexate therapy, since the concentration of the latter in the blood plasma (and, consequently, toxicity) may increase.
Individual cases of bleeding are described with simultaneous application of NSAIDs and anticoagulants.

Terms of sell

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