Ketorolac solution 30mg/ml 1ml #10

Ketorolac user manual

Reed more and buy Ketorolac here

Composition

One tablet of the drug includes 10 mg of ketorolac trometamol (ketorolac tromethamine).
Auxiliary components: cellulose, lactose, calcium stearate, starch, opadrai II.
In 1 ml of the solution for intravenous and intramuscular administration contains 30 mg of ketorolac trometamol.
Excipients: edetate disodium dihydrate, ethanol, sodium chloride, sodium hydroxide, propylene glycol, water.

Form of issue

    Ketorolac (iv, in / m) in ampoules contains a clear solution of white and yellow color.
    1 or 2 ml of such a solution in an ampoule; 10 such ampoules in a cardboard bundle.

pharmachologic effect

Antipyretic, analgesic and anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Has a strong analgesic effect, moderate antipyretic and anti-inflammatory effect.
They are associated with indiscriminate inhibition of the first and second type of cyclooxygenase enzyme in peripheral tissues, as a result of which inhibition of the synthesis of prostaglandins mediators of pain, inflammation and thermoregulation occurs.
The drug has no effect on opioid receptors, does not cause dependence, does not depress respiration, has no sedative and anxiolytic effect.
By the strength of the analgesic effect, it is comparable with morphine and surpasses other preparations of its group.
After oral administration, the analgesic effect is fixed after one hour, the greatest effect is in one to two hours. After intramuscular injection, the beginning of analgesic action is fixed after 30 minutes, the greatest effect is after one or two hours.

Pharmacokinetics

At internal reception and at an injection introduction it is actively absorbed from an intestine and fabrics. The maximum concentration in the blood is recorded after 40-50 minutes, both after oral administration, and after intramuscular injection. The intake of food does not affect the absorption. The binding to plasma proteins is about 99%.
The half-life is approaching 6 o'clock. 90% of the dose is excreted by the kidneys, in the original form - 60%; The remaining amount is output through the digestive tract.

Indications for use

Moderate and severe pain syndrome:
    toothache;
    pain of traumatic etiology;
    pain in the postoperative and postpartum period;
    pain in cancer;
    dislocations, sprains;
    arthralgia, neuralgia, myalgia, sciatica;
    rheumatic diseases.
Used for symptomatic therapy, facilitating inflammation and pain at the time of application, the development of the disease is not affected.

Contraindications

    The combination (complete or incomplete) of bronchial asthma, intolerance to aspirin (or other drugs of this group) and recurrent polyposis of the paranasal sinuses and nose.
    Hypersensitivity.
    Hypovolemia.
    Intolerance to preparations of pyrazolone series.
    Exacerbation of erosive and ulcerative diseases of the gastrointestinal tract.
    Hypocoagulation, high risk of bleeding.
    Severe renal or hepatic lesions, liver disease.
    Condition after aortocoronary shunting.
    Hyperkalemia.
    3rd trimester of pregnancy, childbirth and lactation.
    Bowel inflammation.
    Age is less than 16 years.
With caution apply for: bronchial asthma, alcoholism, chronic heart failure, cholecystitis, postoperative period, arterial hypertension, edematous syndrome, kidney damage, active hepatitis, cholestasis, systemic lupus erythematosus, sepsis, ischemic heart disease, dyslipidemia, cerebrovascular diseases, peripheral arteries, diabetes mellitus, ulcerative lesions of the digestive tract in the past, H. pylori infection, prolonged use of other non-steroidal anti-inflammatory drugs , elderly age, 1 st and 2 nd trimesters of pregnancy.

Side effects
    Reactions from the circulatory system: changes in pressure, bradycardia, palpitations, fainting.
    Reactions from the digestive system: abdominal pain, diarrhea, flatulence, nausea, constipation, vomiting, thirst, gastritis, stomatitis, erosive and ulcerative changes in the organs of the digestive tract, liver damage.
    Reactions from the nervous system: paresthesia, anxiety, sleep disorders, drowsiness, depression, visual impairment, dizziness, motor disorders.
    Response from the respiratory system: attacks of suffocation.
    Reactions from the genitourinary system: oliguria, increased urination, polyuria, proteinuria, hematuria, azotemia, acute renal failure.
    Reactions from the hemopoietic system: nasal bleeding, anemia, eosinophilia, thrombocytopenia.
    Reactions from the metabolism: edema, hypokalemia, an increase in creatinine or urea in the blood, hyponatremia.
    Allergic reactions: hemorrhagic rash, Stevens-Johnson syndrome, urticaria, Quincke's edema, Lyell's syndrome, anaphylactic shock, bronchospasm, myalgia.
    Other reactions: fever.
    Local reactions: pain in the area of ​​injection.

Instructions for use Ketorolac (Method and dosage)

Ketorolac tablets instructions for use recommend their use orally. A single dose of 10 mg. The next application can take 10 mg to four times a day; the maximum daily dose should not be more than 40 mg. Duration of treatment - up to 5 days.
The Ketorolac injections instructions for use recommend that, with intramuscular injection, adhere to a single dose of up to 30 mg every 4 to 6 hours. The highest dose is 90 mg (three ampoules) per day. The greatest duration of drug use is up to 2 days.

Overdose

Symptoms: nausea, abdominal pain, vomiting, metabolic acidosis, kidney damage, erosive and ulcerative changes in the digestive system.
Treatment: symptomatic.

Interaction

Use with other drugs from the same group (OKPD - anti-inflammatory drugs non-steroidal), glucocorticosteroids, corticotropin, ethanol, calcium drugs increases the risk of ulceration of the gastrointestinal tract and the occurrence of bleeding from the stomach and intestines.
Co-administration with heparin, coumarin derivatives, thrombolytics (Streptokinase, Alteplase), cephalosporins, antiplatelet agents, valproic acid and aspirin increases the risk of bleeding.
Ketorolac weakens the effect of diuretic and antihypertensive medications.
Use in conjunction with Methotrexate increases hepato- and nephrotoxicity.
Ketorolac enhances the effect of the use of narcotic analgesics.
Myelotoxic drugs increase the hematotoxic effect of the drug.

Terms of sale

You don't need a prescription to buy Ketorolac.

Storage conditions

    Keep away from children.
    Store in a dark and dry place at temperatures of 15-25 degrees.
Shelf life - two years.

special instructions

Before prescribing the remedy, it is necessary to find out whether there is a previous allergy to other non-steroidal anti-inflammatory drugs.
Hypovolemia increases the risk of developing toxic effects on the kidneys.
If necessary, ketorolac can be prescribed with narcotic analgesics. Do not use the drug for premedication or to maintain anesthesia.
Do not use the product concurrently with paracetamol for more than 5 days.
To reduce the risk of developing gastropathy simultaneously prescribed misoprostol, antacids, omeprazole.
To reduce the risk of side effects, the lowest effective dose should be the shortest possible course.
During treatment with the drug must be careful when driving a car.

Children

It is forbidden to apply to persons under 16 years of age.

During pregnancy (and lactation)

The 3rd trimester of pregnancy, childbirth and lactation are strict contraindications for taking the drug. In the 1st and 2nd trimesters

Reviews

The drug has received good reviews of doctors and patients, from which Ketorolac in tablets and injections of Ketarolac are actively used to relieve pain, despite the high risk of gastrotoxic effects.